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ADAM metallopeptidase with thrombospondin type 1 motif, 19

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: thrombospondin-1, ADAMTS, HAD, AGE, NRF
Papers on ADAMTS19
Next generation sequencing in women affected by nonsyndromic premature ovarian failure displays new potential causative genes and mutations.
Laissue et al., Bogotá, Colombia. In Fertil Steril, Jul 2015
RESULT(S): We have identified mutations in two novel genes, ADAMTS19 and BMPR2, that are potentially related to POF origin.
Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure.
Kwack et al., South Korea. In Menopause, Feb 2015
OBJECTIVE: This study investigated whether epistasis between single nucleotide polymorphisms (SNPs) within ACVR2B (activin A receptor, type IIB) and ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif, 19) genes is associated with premature ovarian failure (POF).
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.
Perucho et al., Barcelona, Spain. In Clin Epigenetics, 2014
BACKGROUND: ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis.
Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos.
Koopman et al., Brisbane, Australia. In Plos One, 2014
Finally, we gained insight into the roles of Adamts19 and Ctrb1, genes of unknown function in sex determination and gonadal development.
Epistasis between IGF2R and ADAMTS19 polymorphisms associates with premature ovarian failure.
Kwack et al., South Korea. In Hum Reprod, 2013
STUDY QUESTION: Do single nucleotide polymorphisms (SNPs) or synergistic interactions between SNPs and diplotypes within the insulin-like growth factor 2 receptor (IGF2R) and ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ADAMTS19), contribute to premature ovarian failure (POF)?
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
Stricker et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Top single-nucleotide polymorphisms in ADAM19, RARB, PPAP2B, and ADAMTS19 were nominally replicated in the COPD meta-analysis.
Genome-wide association study and premature ovarian failure.
Tachdjian et al., Paris, France. In Ann Endocrinol (paris), 2010
So far, three studies have been performed and have identified different loci potentially linked to POF, such as PTHB1 and ADAMTS19.
Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.
Dutch POF Consortium et al., Utrecht, Netherlands. In Hum Reprod, 2009
Although limited by sample size, this proof-of-principle study's findings reveal ADAMTS19 as a possible candidate gene for premature ovarian failure and thus a larger follow-up study is warranted.
Sexually dimorphic gene expression in the developing mouse gonad.
Page et al., Cambridge, United States. In Gene Expr Patterns, 2002
A reciprocal subtraction (of E12.5 XX gonadal cDNA with E12.5 XY gonadal cDNA) yielded two genes, follistatin and Adamts19, that are expressed at higher levels in XX gonads.
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
López-Otín et al., Oviedo, Spain. In Gene, 2002
Expression analysis revealed that these ADAMTS genes are mainly expressed in fetal tissues, especially in lung (ADAMTS14, ADAMTS16, ADAMTS17, ADAMTS18, and ADAMTS19), kidney (ADAMTS14, ADAMTS15, and ADAMTS16), and liver (ADAMTS13, ADAMTS15 and ADAMTS18).
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