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ADAM metallopeptidase with thrombospondin type 1 motif, 7

ADAMTS-7
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ADAMTS, thrombospondin-1, Comp, ADAMTS-12, V1a
Papers on ADAMTS-7
Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA).
New
Bluemke et al., Washington, D.C., United States. In Atherosclerosis, Jan 2016
In HIS, CAC was associated with SNPs in 9p21 (rs1333049, P = 8 × 10(-5); rs4977574, P = 5 × 10(-5)), APOA5 (rs964184, P = 2 × 10(-4)), and ADAMTS7 (rs7173743, P = 4 × 10(-4)).
SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis.
New
Wang et al., Beijing, China. In Osteoarthritis Cartilage, Dec 2015
SOX9 was recruited to the promoters of ADAMTS-4 and ADAMTS-7.
IL-17A enhances ADAMTS-7 expression through regulation of TNF-α in human nucleus pulposus cells.
New
Nie et al., Jinan, China. In J Mol Histol, Dec 2015
Immunohistochemistry, RT-PCR and western Blotting were used to investigate the expression of ADAMTS-7 in NP tissues.
ADAMTS7 locus confers high cross-race risk for development of coronary atheromatous plaque.
New
Cui et al., Shijiazhuang, China. In Mol Genet Genomics, Aug 2015
UNASSIGNED: Genome-wide association studies of coronary artery disease (CAD) have recently identified a new susceptibility locus, ADAMTS7, in subjects of European ancestry.
ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo.
New
Kong et al., Beijing, China. In Sci China Life Sci, Jul 2015
We have recently reported that a disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7), a novel metalloproteinase, contributes directly to neointima formation by mediating VSMC migration.
A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche.
New
Petersen et al., Gainesville, United States. In Am J Pathol, Jun 2015
By using the Yeast Two-Hybrid approach, we identified a disintegrin and metalloproteinase with thrombospondin repeat 7 (ADAMTS7) as a CTGF binding protein.
Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice.
New
Liu et al., New York City, United States. In Mol Cell Biochem, Jun 2015
The aim of the present study is to determine whether ADAMTS-7 contributes to the onset and severity of joint inflammation in the pathogenesis of inflammatory arthritis.
Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.
Review
New
Apte et al., Cleveland, United States. In Matrix Biol, May 2015
Genome-wide analyses have determined an association of some ADAMTS loci such as ADAMTS9 and ADAMTS7, with specific traits and acquired disorders.
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family.
Review
Edwards et al., Norwich, United Kingdom. In Genome Biol, 2014
The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases or proteoglycanases (ADAMTS1, 4, 5, 8, 9, 15 and 20), the procollagen N-propeptidases (ADAMTS2, 3 and 14), the cartilage oligomeric matrix protein-cleaving enzymes (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADAMTS6, 10, 16, 17, 18 and 19).
The Function and Roles of ADAMTS-7 in Inflammatory Diseases.
Review
Wei et al., Jinan, China. In Mediators Inflamm, 2014
ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the pathogenesis of arthritis.
Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction.
Zheng et al., Beijing, China. In Eur J Med Res, 2014
The study aimed to examine plasma ADAMTS-7 levels in patients with acute myocardial infarction (AMI) and the relationship between plasma ADAMTS-7 levels and heart function.
Proteinases and plaque rupture: unblocking the road to translation.
Review
Newby, Bristol, United Kingdom. In Curr Opin Lipidol, 2014
For ADAMs with ThromboSpondin domains (ADAMTSs), there are biological and genome-wide association data linking ADAMTS-7 to incidence of coronary heart disease but not increased risk of myocardial infarctions.
Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation.
GeneRIF
Wang et al., Beijing, China. In J Orthop Res, 2012
statistically significant increase in mRNA expression of ADAMTS-7 and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs
Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
GeneRIF
Zhu et al., Shenyang, China. In J Vet Med Sci, 2012
ADAMTS-7 and ADAMTS-12 expression were dramatically increased during disc degeneration.
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
Impact
Coronary Artery Disease (C4D) Genetics Consortium, In Nat Genet, 2011
Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11.
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
Impact
GeneRIF
Rader et al., Philadelphia, United States. In Lancet, 2011
identified ADAMTS7 as novel locus for CAD and association of ABO with MI in the presence of CAD
The role of ADAMTSs in arthritis.
Review
Liu et al., New York City, United States. In Protein Cell, 2010
This review briefly summarizes the structural organization and functional roles of ADAMTSs in normal and pathological conditions, focusing on members that are known to be involved in the degradation of extracellular matrix and loss of cartilage in arthritis, including the aggrecanases (ADAMTS-4 and ADAMTS-5), ADAMTS-7 and ADAMTS-12, the latter two are associated with cartilage oligomeric matrix protein (COMP), a component of the cartilage extracellular matrix (ECM).
ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.
GeneRIF
Liu et al., New York City, United States. In Mol Cell Biol, 2009
Findings demonstrate that ADAMTS-7, a direct target of PTHrP signaling, negatively regulates endochondral bone formation by associating with and inactivating GEP chondrogenic growth factor.
ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.
GeneRIF
Wang et al., Beijing, China. In Circ Res, 2009
ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.
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