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ADAM metallopeptidase domain 28
ADAM23, ADAM28, MDC3, MDCL
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
metalloprotease, HAD, ADAM9, ADAM12, TACE
Papers on
ADAM23
Imatinib reduces cholesterol uptake and matrix metalloproteinase activity in human THP-1 macrophages.
New
Linköping, Sweden. In Pharmacol Rep, Feb 2016
Instead, we found that imatinib up-regulated microRNA 155 (miR155) by 43.8% and down-regulated ADAM metallopeptidase domain 28 (ADAM28) by 41.4%.
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
New
Copenhagen, Denmark. In Hum Mol Genet, Feb 2016
We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23.
EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells.
New
London, United Kingdom. In Plos Pathog, Jan 2016
COBLL1, a gene of unknown function, is regulated by EBNA3C alone and the two co-regulated disintegrin/metalloproteases, ADAM28 and ADAMDEC1 have been described previously as targets of both EBNA3A and EBNA3C.
Impact of sex differences in brain response to infection with Plasmodium berghei.
New
Riyadh, Saudi Arabia. In Parasitol Res, Nov 2015
At the molecular level, P. berghei was able to induce upregulations of Adam23, Cabp1, Cacnb4, Glrb, and Vdac3-mRNA in the brain of mice.
Impact of gold nanoparticles on brain of mice infected with Schistosoma mansoni.
New
Riyadh, Saudi Arabia. In Parasitol Res, Oct 2015
In addition, S. mansoni was able to disregulate the infected mice brain Cacnb4, Cabp4, Vdac3, Glrb, and Adam23 messenger RNA (mRNA).
Autistic and Rett-like features associated with 2q33.3-q34 interstitial deletion.
New
Seoul, South Korea. In Am J Med Genet A, Sep 2015
Candidate genes were identified as NRP2, ADAM23, KLF7, CREB1, MAP2, UNC80, and LANCL1 for the 2q33.3-q34
ADAM28 overexpression regulated via the PI3K/Akt pathway is associated with relapse in de novo adult B-cell acute lymphoblastic leukemia.
New
Beijing, China. In Leuk Res, Sep 2015
ADAM28 is overexpressed in several human tumors and is related to cell proliferation and lymph node metastasis.
Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone.
Ribeirão Preto, Brazil. In J Cancer, 2014
The expression of the ADAM23 and CDKN2A genes was decreased in GCTB samples compared to normal bone tissue, measured by qPCR.
Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene.
Helsinki, Finland. In Bmc Genomics, 2014
A targeted resequencing of the 4.4 megabase region in twelve Belgian Shepherd cases and twelve controls with opposite haplotypes identified 37 case-specific variants within the ADAM23 gene.
[Research advances on ADAM28 expression and ADAM28-mediated tumor metastasis].
Review
Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2014
A disintegrin-metalloproteinase 28 (ADAM28) is one of important members of ADAM family, that is involved in various biological events including cell adhesion, proteolysis, growth and metastasis of solid tumors and hematological malignancies.
LGI1: from zebrafish to human epilepsy.
Review
Augusta, United States. In Prog Brain Res, 2013
LGI1 binds to ADAM23 on the presynaptic membrane and ADAM22 on the postsynaptic membrane, further implicating it in regulating the strength of synaptic transmission.
ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
Review
Dublin, Ireland. In Vitam Horm, 2012
A number of ADAM proteins have been implicated in the occurrence of breast cancer, including ADAM 9, ADAM12, ADAM15, ADAM17, ADAM22, and ADAM28.
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
GeneRIF
Tokyo, Japan. In J Natl Cancer Inst, 2012
ADAM28 cleaves and inactivates proapoptotic VWF in carcinoma cells and enhances lung metastasis probably by promoting carcinoma cell survival within the blood vessels.
Urinary protein profiling by liquid chromatography/tandem mass spectrometry: ADAM28 is overexpressed in bladder transitional cell carcinoma.
GeneRIF
Kao-hsiung, Taiwan. In Rapid Commun Mass Spectrom, 2011
Study shows using proteomics that ADAM28 may be used as a possible biomarker of bladder cancer.
The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma.
GeneRIF
Changsha, China. In Int J Exp Pathol, 2011
The expression level of ADAM23 is likely to be involved in the progression of non-small-cell lung carcinoma, and its downregulation is probably correlated with promoter methylation.
Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis.
GeneRIF
Taiwan. In Biochem Biophys Res Commun, 2011
ADAM28 showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer.
A proteomic approach for identification and localization of the pericellular components of chondrocytes.
GeneRIF
Saint Louis, United States. In Histochem Cell Biol, 2011
A proteomic approach for identification and localization of the pericellular components of chondrocytes
Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series.
Impact
Philadelphia, United States. In Lancet Neurol, 2010
An assay with HEK293 cells transfected with leucine-rich, glioma-inactivated 1 (LGI1) and disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) or ADAM23 was used as a serological test.
ADAM28 as a target for human cancers.
Review
Tokyo, Japan. In Curr Pharm Des, 2008
ADAM28 is a member of the ADAM (a disintegrin and metalloproteinase) gene family and consists of two isoforms, prototype membrane-type form and short secreted form.
ADAMs in cancer cell proliferation and progression.
Review
Tokyo, Japan. In Cancer Sci, 2007
Many ADAM species, including ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19, ADAM28, ADAMTS1, ADAMTS4 and ADAMTS5, are expressed in human malignant tumors.
