The role of ADAMs in disease pathophysiology.
Dublin, Ireland. In Clin Chim Acta, 2009
Multiple ADAMs, including ADAM-9, ADAM-10, ADAM-12, ADAM-15 and ADAM-17, have been shown to play a role in either cancer formation or progression.
The therapeutic potential of ADAM15.
Ann Arbor, United States. In Curr Pharm Des, 2008
ADAM15 is a widely expressed multi-domain protease that has been implicated in the pathogenesis of many human diseases.
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
New York City, United States. In Nat Immunol, 2006
Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify ADAM10 as the main CD23-releasing enzyme in vivo.