η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
München, Germany. In Nature, Nov 2015
We identify higher molecular mass carboxy-terminal fragments (CTFs) of APP, termed CTF-η, in addition to the long-known CTF-α and CTF-β fragments generated by the α- and β-secretases ADAM10 (a disintegrin and metalloproteinase 10) and BACE1 (β-site APP cleaving enzyme 1), respectively.
The soluble leptin receptor.
Leipzig, Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
Lipotoxicity and apoptosis increase OB-R cleavage via ADAM10-dependent mechanisms.
Novel receptors for bacterial protein toxins.
Freiburg, Germany. In Curr Opin Microbiol, Feb 2015
Using optimized protocols and new methods novel toxin receptors have been identified, including metalloprotease ADAM 10 for Staphylococcus aureus α-toxin, laminin receptor Lu/BCAM for Escherichia coli cytotoxic necrotizing factor CNF1, lipolysis stimulated lipoprotein receptor (LSR) for Clostridium difficile transferase CDT and low-density lipoprotein receptor-related protein (LRP) 1 for Clostridium perfringens TpeL toxin.