η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
München, Germany. In Nature, Nov 2015
We identify higher molecular mass carboxy-terminal fragments (CTFs) of APP, termed CTF-η, in addition to the long-known CTF-α and CTF-β fragments generated by the α- and β-secretases ADAM10 (a disintegrin and metalloproteinase 10) and BACE1 (β-site APP cleaving enzyme 1), respectively.
The soluble leptin receptor.
Leipzig, Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
Lipotoxicity and apoptosis increase OB-R cleavage via ADAM10-dependent mechanisms.