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Transcriptional adaptor 2A

ADA2, Ada2p
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ADA1, Histone, CAN, ADA3, ACID
Papers on ADA2
Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult.
Schetinger et al., Santa Maria, Brazil. In Mol Cell Biochem, 31 May 2015
The ADA1 activity (92.6 %) was significantly higher than ADA2 (7.4 %) activity in the cerebral cortex eight days after HI.
Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV-HBV and HIV-HCV Coinfections.
Khodadadi et al., Sanandaj, Iran. In J Clin Lab Anal, Mar 2015
CD4(+) cell count, serum total ADA (tADA), and ADA1, and ADA2 isoenzyme activities were determined and their sensitivity and specificity were computed.
Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1.
Toczyski et al., San Francisco, United States. In Mol Cell Proteomics, Jan 2015
Furthermore, by examining global acetylation in an ada2 mutant, which dissociates Gcn5 from the SAGA complex, we found that a subset of Gcn5 targets did not depend on an intact SAGA complex for targeting.
Genetics of vasculitis.
González-Gay et al., Johannesburg, South Africa. In Curr Opin Rheumatol, Jan 2015
These associations include ERAP1, CCR1-CCR3, STAT4, KLRC4, GIMAP4, and TNFAIP3 in Behçet's disease; BLK and CD40 in Kawasaki disease; SERPINA1 and SEMA6A in antineutrophil cytoplasmic antibody associated vasculitides; IL12B and FCGR2A/ FCGR2A in Takayasu arteritis; and CECR1 in a newly defined vascular inflammatory syndrome associated with adenosine deaminase (ADA2) deficiency.
MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes.
Liou et al., Augusta, United States. In Biomed Res Int, Dec 2014
ADA, including ADA1 and ADA2, exists in all organisms.
Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism.
Chiariello et al., Roma, Italy. In World J Cardiol, Jul 2014
A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group.
Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
Levy-Lahad et al., Aş Şanamayn, Syria. In N Engl J Med, Apr 2014
RESULTS: In all the families, vasculitis was caused by recessive mutations in CECR1, the gene encoding adenosine deaminase 2 (ADA2).
Early-onset stroke and vasculopathy associated with mutations in ADA2.
Aksentijevich et al., Aş Şanamayn, Syria. In N Engl J Med, Apr 2014
RESULTS: All nine patients carried recessively inherited mutations in CECR1 (cat eye syndrome chromosome region, candidate 1), encoding adenosine deaminase 2 (ADA2), that were predicted to be deleterious; these mutations were rare or absent in healthy controls.
Mutations in CECR1 associated with a neutrophil signature in peripheral blood.
Crow et al., Lyon, France. In Pediatr Rheumatol Online J, 2013
BACKGROUND: A reduction of ADA2 activity due to autosomal recessive loss of function mutations in CECR1 results in a newly described vasculopathic phenotype reminiscent of polyarteritis nodosa, with manifestations ranging from fatal systemic vasculitis with multiple strokes in children to limited cutaneous disease in middle-aged individuals.
Adenosine deaminase activity in normal pregnancy and pregnancy associated disorders.
Jain et al., Bhopāl, India. In Arch Physiol Biochem, 2013
Adenosine deaminase (ADA) is an enzyme of purine salvage pathway and has two important isoenzymes ADA1 and ADA2.
CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.
Qiu et al., Beijing, China. In Histochem Cell Biol, 2012
CCDC134 increased the PCAF-dependent K320 acetylation of p53 and p53 protein stability in the presence of hADA2a overexpression.
The SAGA subunit Ada2 functions in transcriptional silencing.
Pillus et al., San Diego, United States. In Mol Cell Biol, 2009
Ada2, likely in the context of SAGA, is positioned at chromosomal termini to participate in both transcriptional repression and activation in response to nutrient signaling.
A conserved central region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and interacts with phospholipids.
Brandl et al., London, Canada. In J Mol Biol, 2009
Indicative of Ada2 affecting Gcn5 function, Ada2 mutation resulted in a decrease in Gcn5-mediated histone acetylation in vitro to a level approximately 40% that with wild-type Ada2.
hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin.
Brachmann et al., Irvine, United States. In Cancer Biol Ther, 2008
hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes.
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope.
Nehrbass et al., Paris, France. In Nature, 2006
This confinement was mediated by Sus1 and Ada2, members of the SAGA histone acetyltransferase complex, and Sac3, a messenger RNA export factor, physically linking the activated GAL genes to the nuclear-pore-complex component Nup1.
Roles for Gcn5p and Ada2p in transcription and nucleotide excision repair at the Saccharomyces cerevisiae MET16 gene.
Waters et al., Oviedo, Spain. In Nucleic Acids Res, 2005
Ada2p regulates transcription and DNA repair at the MET16 gene.
The use of adenosine deaminase and adenosine deaminase isoenzymes in the diagnosis of tuberculous pleuritis.
Jiménez Castro et al., Madrid, Spain. In Curr Opin Pulm Med, 2000
Adenosine deaminase expresses the sum of two isoenzymes (ADA1 and ADA2).
The cellular response to protein misfolding in the endoplasmic reticulum.
Kaufman et al., Ann Arbor, United States. In Gene Expr, 1998
A yeast transcriptional coactivator complex, Gcn5p/Ada, which is composed of Gcn5p, Ada2p, Ada3p, and Ada5p, was identified that interacts with Ire1p and Hac1p.
[Adenosine deaminase: isoenzymes ADA1 and ADA2].
Puczkowski et al., In Pol Merkur Lekarski, 1997
The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA deaminate mainly two nucleotides: adenosine and 2'-deoxyadenosine, molecules with many effects on human cells.
Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains.
Guarente et al., Cambridge, United States. In Cell, 1992
We thus identified ADA1, ADA2, and ADA3.
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