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Transcriptional adaptor 2A

ADA2, Ada2p
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ADA1, Histone, CAN, ADA3, ACID
Papers on ADA2
Further observations on associations between the ADA gene and past malaria morbidity in Sardinia.
New
Bottini et al., Roma, Italy. In Am J Hum Biol, 30 Sep 2014
We have now studied the ADA2 locus, another polymorphic site with two alleles ADA2 *1 and ADA2 *2 within the ADA gene.
SAGA/ADA complex subunit Ada2 is required for Cap1- but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1.
New
Morschhäuser et al., Würzburg, Germany. In Antimicrob Agents Chemother, 30 Sep 2014
It has been suggested that Mrr1 activates MDR1 transcription by recruiting Ada2, a subunit of the SAGA/ADA coactivator complex.
Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism.
Review
New
Chiariello et al., Roma, Italy. In World J Cardiol, Jul 2014
A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group.
Novel adenosine deaminase 2 mutations in a child with a fatal vasculopathy.
New
Tekin et al., Miami, United States. In Eur J Pediatr, Jun 2014
Adenosine deaminase 2 (ADA2) deficiency due to CECR1 mutations is a recently defined disorder that involves systemic inflammation and vasculopathy often associated with polyarteritis nodosa.
Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
New
Impact
Levy-Lahad et al., Aş Şanamayn, Syria. In N Engl J Med, Apr 2014
RESULTS: In all the families, vasculitis was caused by recessive mutations in CECR1, the gene encoding adenosine deaminase 2 (ADA2).
Early-onset stroke and vasculopathy associated with mutations in ADA2.
New
Impact
Aksentijevich et al., Aş Şanamayn, Syria. In N Engl J Med, Apr 2014
RESULTS: All nine patients carried recessively inherited mutations in CECR1 (cat eye syndrome chromosome region, candidate 1), encoding adenosine deaminase 2 (ADA2), that were predicted to be deleterious; these mutations were rare or absent in healthy controls.
Coronary artery disease. A study of three polymorphic sites of adenosine deaminase gene.
New
Gloria-Bottini et al., In Acta Cardiol, Feb 2014
The recent observation of an association between ADA, genetic polymorphism and coronary artery disease (CAD) prompted us to study the possible relevance of three intragenic polymorphic sites of the ADA gene (ADA1, ADA2 and ADA6).
Mutations in CECR1 associated with a neutrophil signature in peripheral blood.
New
Crow et al., Lyon, France. In Pediatr Rheumatol Online J, Dec 2013
BACKGROUND: A reduction of ADA2 activity due to autosomal recessive loss of function mutations in CECR1 results in a newly described vasculopathic phenotype reminiscent of polyarteritis nodosa, with manifestations ranging from fatal systemic vasculitis with multiple strokes in children to limited cutaneous disease in middle-aged individuals.
Diagnostic accuracy of tumor necrosis factor-alpha, interferon-gamma, interlukine-10 and adenosine deaminase 2 in differential diagnosis between tuberculous pleural effusion and malignant pleural effusion.
New
Xi et al., Xinxiang, China. In J Cardiothorac Surg, Dec 2013
We tested the pleural levels of TNF-α, IFN-γ and IL-10 as well as the enzyme activity of ADA2, and then we compared the differential diagnostic efficiencies of those biochemical parameters with ADA between the two groups.
Adenosine deaminase activity in normal pregnancy and pregnancy associated disorders.
Review
New
Jain et al., Bhopāl, India. In Arch Physiol Biochem, May 2013
Adenosine deaminase (ADA) is an enzyme of purine salvage pathway and has two important isoenzymes ADA1 and ADA2.
CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.
GeneRIF
Qiu et al., Beijing, China. In Histochem Cell Biol, 2012
CCDC134 increased the PCAF-dependent K320 acetylation of p53 and p53 protein stability in the presence of hADA2a overexpression.
The SAGA subunit Ada2 functions in transcriptional silencing.
GeneRIF
Pillus et al., San Diego, United States. In Mol Cell Biol, 2009
Ada2, likely in the context of SAGA, is positioned at chromosomal termini to participate in both transcriptional repression and activation in response to nutrient signaling.
A conserved central region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and interacts with phospholipids.
GeneRIF
Brandl et al., London, Canada. In J Mol Biol, 2009
Indicative of Ada2 affecting Gcn5 function, Ada2 mutation resulted in a decrease in Gcn5-mediated histone acetylation in vitro to a level approximately 40% that with wild-type Ada2.
hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin.
GeneRIF
Brachmann et al., Irvine, United States. In Cancer Biol Ther, 2008
hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes.
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope.
Impact
Nehrbass et al., Paris, France. In Nature, 2006
This confinement was mediated by Sus1 and Ada2, members of the SAGA histone acetyltransferase complex, and Sac3, a messenger RNA export factor, physically linking the activated GAL genes to the nuclear-pore-complex component Nup1.
Roles for Gcn5p and Ada2p in transcription and nucleotide excision repair at the Saccharomyces cerevisiae MET16 gene.
GeneRIF
Waters et al., Oviedo, Spain. In Nucleic Acids Res, 2005
Ada2p regulates transcription and DNA repair at the MET16 gene.
The use of adenosine deaminase and adenosine deaminase isoenzymes in the diagnosis of tuberculous pleuritis.
Review
Jiménez Castro et al., Madrid, Spain. In Curr Opin Pulm Med, 2000
Adenosine deaminase expresses the sum of two isoenzymes (ADA1 and ADA2).
The cellular response to protein misfolding in the endoplasmic reticulum.
Review
Kaufman et al., Ann Arbor, United States. In Gene Expr, 1998
A yeast transcriptional coactivator complex, Gcn5p/Ada, which is composed of Gcn5p, Ada2p, Ada3p, and Ada5p, was identified that interacts with Ire1p and Hac1p.
[Adenosine deaminase: isoenzymes ADA1 and ADA2].
Review
Puczkowski et al., In Pol Merkur Lekarski, 1997
The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleotides: adenosine and 2'-deoxyadenosine, molecules with many effects on human cells.
Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains.
Impact
Guarente et al., Cambridge, United States. In Cell, 1992
We thus identified ADA1, ADA2, and ADA3.
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