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Transcriptional adaptor 2A
ADA2, Ada2p
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009] (from
NCBI)
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Papers on
ADA2
Identification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes.
New
Denizli, Turkey. In Biochem J, 01 Apr 2013
Within the HAT complexes ADA3 is associated with ADA2 and the HAT GCN5 (general control non-repressed 5).
Functional characterization and gene expression profiling of Drosophila melanogaster short dADA2b isoform-containing dSAGA complexes.
New
In Bmc Genomics, 22 Feb 2013
ABSTRACT: BACKGROUND: ADA2 proteins, together with ADA3, SGF9 and GCN5 form the acetyltransferase module of GNAT-type histone acetyltransferase complexes.
Comparison of polymorphonuclear- and lymphocyte-rich tuberculous pleural effusions.
New
Lleida, Spain. In Int J Tuberc Lung Dis, Jan 2013
Compared with those whose pleural fluid was predominantly lymphocytic, these patients showed a higher yield of mycobacteria in culture of sputum (50% vs. 25%, P = 0.03) and pleural fluid (50% vs. 10%, P < 0.01) on solid media, as well as higher pleural adenosine deaminase (ADA) levels (80 vs. 62 U/l, P = 0.02) at the expense of both ADA1 and ADA2 isoenzymes.
The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation.
New
Szeged, Hungary. In Febs Lett, Oct 2012
ADA2 adaptor proteins are essential subunits of GCN5-containing histone acetyltransferase (HAT) complexes.
Adenosine deaminase activity in fertile and infertile men.
New
Hamadān, Iran. In Andrologia, May 2012
The purpose of this study was to determine the plasma activities of total adenosine deaminase (ADAT), and its isoenzymes, ADA1 and ADA2, in fertile and infertile men.
Role of the purinergic system in patients with cervical intraepithelial neoplasia and uterine cancer.
New
Santa Maria, Brazil. In Biomed Pharmacother, Feb 2012
METHODS: NTPDase, E-NPP, 5'-nucleotidase, total ADA and its isoforms (ADA1 and ADA2), as well as the platelet aggregation from patients with different stages of cervical intraepithelial neoplasia (NICs I, NIC II, NIC III) and uterine invasive cancer were verified.
Nitric oxide - an activating factor of adenosine deaminase 2 in vitro.
Yerevan, Armenia. In Biochemistry (mosc), 2012
In this study we have investigated the effect of reactive oxygen species produced by some chemicals in aqueous solutions on activity of adenosine deaminase 2 (ADA2) purified from human blood plasma.
Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV-HBV co-infected patients.
Hamadān, Iran. In Clin Biochem, 2011
Blood CD4+ cell count was recorded and serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total ADA, and ADA1 and ADA2 isoenzyme activities were determined.
The SAGA subunit Ada2 functions in transcriptional silencing.
GeneRIF
San Diego, United States. In Mol Cell Biol, 2009
Ada2, likely in the context of SAGA, is positioned at chromosomal termini to participate in both transcriptional repression and activation in response to nutrient signaling.
A conserved central region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and interacts with phospholipids.
GeneRIF
London, Canada. In J Mol Biol, 2009
Indicative of Ada2 affecting Gcn5 function, Ada2 mutation resulted in a decrease in Gcn5-mediated histone acetylation in vitro to a level approximately 40% that with wild-type Ada2.
hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin.
GeneRIF
Irvine, United States. In Cancer Biol Ther, 2008
hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes.
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope.
Impact
Paris, France. In Nature, 2006
This confinement was mediated by Sus1 and Ada2, members of the SAGA histone acetyltransferase complex, and Sac3, a messenger RNA export factor, physically linking the activated GAL genes to the nuclear-pore-complex component Nup1.
Structure and chromosomal DNA binding of the SWIRM domain.
GeneRIF
New York City, United States. In Nat Struct Mol Biol, 2005
The three-dimensional solution structure of the SWIRM domain from the human transcriptional adaptor ADA2alpha was reported.
Roles for Gcn5p and Ada2p in transcription and nucleotide excision repair at the Saccharomyces cerevisiae MET16 gene.
GeneRIF
Oviedo, Spain. In Nucleic Acids Res, 2005
Ada2p regulates transcription and DNA repair at the MET16 gene.
The use of adenosine deaminase and adenosine deaminase isoenzymes in the diagnosis of tuberculous pleuritis.
Review
Madrid, Spain. In Curr Opin Pulm Med, 2000
Adenosine deaminase expresses the sum of two isoenzymes (ADA1 and ADA2).
The cellular response to protein misfolding in the endoplasmic reticulum.
Review
Ann Arbor, United States. In Gene Expr, 1998
A yeast transcriptional coactivator complex, Gcn5p/Ada, which is composed of Gcn5p, Ada2p, Ada3p, and Ada5p, was identified that interacts with Ire1p and Hac1p.
[Adenosine deaminase: isoenzymes ADA1 and ADA2].
Review
In Pol Merkur Lekarski, 1997
The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleotides: adenosine and 2'-deoxyadenosine, molecules with many effects on human cells.
Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains.
Impact
Cambridge, United States. In Cell, 1992
We thus identified ADA1, ADA2, and ADA3.
Serum adenosine deaminase activity in HIV positive subjects. A hypothesis on the significance of ADA2.
Review
In Panminerva Med, 1989
According to relative substrate specificities, optimal pH and Km, enzymatic activity can be attributed principally to the ADA2 isoenzyme.
