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Aminoacylase 1

acylase, aminoacylase, ACY1, aminoacylase-1
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, STEP, HAD, fibrillin-1
Papers on acylase
Fully automatized high-throughput enzyme library screening using a robotic platform.
New
Bornscheuer et al., Greifswald, Germany. In Biotechnol Bioeng, Feb 2016
The performance of this system has been exemplified for four enzyme classes important for biocatalysis such as Baeyer-Villiger monooxygenase, transaminase, dehalogenase and acylase in the high-throughput screening of various mutant libraries.
Expanding the phenotype in aminoacylase 1 (ACY1) deficiency: characterization of the molecular defect in a 63-year-old woman with generalized dystonia.
New
Wevers et al., Rheinbach, Germany. In Metab Brain Dis, Jan 2016
UNASSIGNED: Aminoacylase 1 (ACY1) deficiency is an organic aciduria due to mutations in the ACY1 gene.
Structural analysis of a penicillin V acylase from Pectobacterium atrosepticum confirms the importance of two Trp residues for activity and specificity.
New
Ramasamy et al., Pune, India. In J Struct Biol, Jan 2016
UNASSIGNED: Penicillin V acylases (PVA) catalyze the deacylation of the beta-lactam antibiotic phenoxymethylpenicillin (Pen V).
Quorum-Quenching and Matrix-Degrading Enzymes in Multilayer Coatings Synergistically Prevent Bacterial Biofilm Formation on Urinary Catheters.
New
Tzanov et al., Terrassa, Spain. In Acs Appl Mater Interfaces, Jan 2016
To this end, coatings composed of the enzymes acylase and α-amylase, able to degrade bacterial QS molecules and polysaccharides, respectively, were built on silicone urinary catheters using a layer-by-layer deposition technique.
[Cephalosporin-Acid Synthetase of Escherichia coli Strain VKPM B-10182: Genomic Context, Gene Identification, Producer Strain Production].
New
Yarockii et al., In Prikl Biokhim Mikrobiol, Sep 2015
The CASA gene--a direct homolog of the penicillin G-acylase gene--was identified by bioinformatics methods.
Purification and characterization of enantioselective N-acetyl-β-Phe acylases from Burkholderia sp. AJ110349.
Nakamatsu et al., Kawasaki, Japan. In Biosci Biotechnol Biochem, 2015
Both (R)- and (S)-enantioselective N-acetyl-β-Phe acylase were expressed in Escherichia coli.
Enzymes from Extreme Environments and Their Industrial Applications.
Review
Littlechild, Exeter, United Kingdom. In Front Bioeng Biotechnol, 2014
Some of the extremophilic enzymes to be discussed have already been developed for industrial processes such as an l-aminoacylase and a γ-lactamase.
Current state and perspectives of penicillin G acylase-based biocatalyses.
Review
Kyslík et al., Praha, Czech Republic. In Appl Microbiol Biotechnol, 2014
In the course of more than 60-year history, penicillin G acylase (PGA) gained a unique position among enzymes used by pharmaceutical industry for production of β-lactam antibiotics.
Biotechnological advances on penicillin G acylase: pharmaceutical implications, unique expression mechanism and production strategies.
Review
Chou et al., Waterloo, Canada. In Biotechnol Adv, 2013
Penicillin G acylase (PGA) is one of the most relevant and widely used biocatalysts for the industrial production of β-lactam semisynthetic antibiotics.
Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection.
Review
Li et al., Dalian, China. In Int J Mol Sci, 2012
Quorum quenching enzymes have been identified in quorum sensing and non-quorum sensing microbes, including lactonase, acylase, oxidoreductase and paraoxonase.
Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis
Review
Schreiber et al., Bethesda, United States. In Unknown Journal, 2012
Several enzymes such as the PvdQ acylase are required for the biosynthesis of pyoverdine.
Differential aminoacylase expression in neuroblastoma.
GeneRIF
Jaworski et al., Burlington, United States. In Int J Cancer, 2011
These data suggest that aminoacylase expression is dysregulated in neuroblastoma.
The molecular basis of aminoacylase 1 deficiency.
GeneRIF
Sass et al., Freiburg, Germany. In Biochim Biophys Acta, 2011
aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis
Probing the acyl-binding pocket of aminoacylase-1.
GeneRIF
Sulea et al., Montréal, Canada. In Biochemistry, 2008
T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids
Acylase 1 expression in rat intestinal crypt--villus axis.
GeneRIF
Perrier et al., Marseille, France. In Cell Biol Int, 2007
These findings proposed ACY 1 as a new marker transcript for absorbing cells of intestinal crypt, which can be used to monitor the process of intestinal N-alpha-acetylated protein metabolism.[ACY 1]
The amidase activity of human tissue kallikrein is significantly lower in the urine of patients with systolic heart failure.
GeneRIF
De Souza Figueiredo et al., In J Card Fail, 2006
Because hK1 amidase activity is significantly lower in urine of systolic HF patients, it can be supposed that activity of renal kallikrein-kinin system may be suppressed in this systolic heart failure.
Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum.
Impact
Barredo et al., León, Spain. In Nat Biotechnol, 2000
DAOC deacylation is carried out by two final enzymatic bioconversions catalyzed by D-amino acid oxidase (DAO) and glutaryl acylase (GLA) yielding 7-ADCA.
Autocatalytic processing of the 20S proteasome.
Impact
Baumeister et al., München, Germany. In Nature, 1996
The four currently known Ntn hydrolases (glutamine PRPP amidotransferase, penicillin acylase, the 20S proteasome and aspartylglucosaminidase) are encoded as inactive precursors, and are activated by cleavage of the peptide bond preceding the catalytic residue.
A protein catalytic framework with an N-terminal nucleophile is capable of self-activation.
Impact
Murzin et al., York, United Kingdom. In Nature, 1995
The crystal structures of three amidohydrolases have been determined recently: glutamine PRPP amidotransferase (GAT), penicillin acylase, and the proteasome.
Penicillin acylase has a single-amino-acid catalytic centre.
Impact
Moody et al., York, United Kingdom. In Nature, 1995
Penicillin acylase (penicillin amidohydrolase, EC 3.5.1.11)
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