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Activin A receptor, type IIA

ActRIIA, ACVR2, ACVR2A, activin receptor type IIA, type II activin receptor
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SFRP1, ActRIIB, IIa, TGF-beta, follistatin
Papers on ActRIIA
Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice.
New
Babitt et al., Reggio nell'Emilia, Italy. In Endocrinology, Feb 2016
Activin B stimulates hepcidin via classical Activin type II receptors ACVR2A and ACVR2B, noncanonical BMP type I receptors ALK2 and ALK3, and SMAD5.
Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regeneration.
Review
New
Vergely et al., Dijon, France. In Pharmacol Ther, Dec 2015
The binding of activins to activin type IIA (ActRIIA) or type IIB (ActRIIB) receptors induces the recruitment and phosphorylation of an activin type I receptor which then phosphorylates the Smad2 and Smad3 intracellular signaling proteins.
The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders.
New
Tomizuka et al., Machida, Japan. In Sci Rep, Dec 2015
Recently, several soluble BMP receptors, such as ActRIIA-Fc, ActRIIB-Fc, and ALK1-Fc, are undergoing clinical trials.
Muscle-bone interactions: From experimental models to the clinic? A critical update.
New
Jardí et al., Leuven, Belgium. In Mol Cell Endocrinol, Nov 2015
Novel antiresorptive and anabolic therapies are emerging for osteoporosis as well as drugs for sarcopenia, cancer cachexia or muscle wasting disorders, including antibodies against myostatin or activin receptor type IIA and IIB (e.g.
Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production.
New
Keogh et al., Melbourne, Australia. In Pregnancy Hypertens, Oct 2015
METHODS AND RESULTS: Immunostaining demonstrated the presence of the activin A receptor, ACVR2A, in SGHEC-7 cells used to model the vascular endothelium.
Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma.
New
Chung et al., Seoul, South Korea. In Oncotarget, Oct 2015
All MSU cases exhibited clonal, truncating mutations in ACVR2A, TGFBR2, and DNA mismatch repair genes, but none were present in APC or KRAS.
Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation.
New
Teixeira et al., Porto, Portugal. In Br J Cancer, Sep 2015
RESULTS: The most frequently mutated genes belong to the TGF-β superfamily pathway, namely ACVR2A and TGFBR2.
Pathophysiology of the chronic kidney disease-mineral bone disorder.
Review
New
Sugatani et al., Springfield, United States. In Curr Opin Nephrol Hypertens, Jul 2015
The type 2 activin A receptor, ActRIIA, is decreased by CKD in atherosclerotic aortas, specifically in vascular smooth muscle cells (VSMC).
Microsatellite instability: an update.
Review
New
Imai et al., Kawasaki, Japan. In Arch Toxicol, Jun 2015
Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype.
Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker.
Review
New
Kenny et al., Cork, Ireland. In Cytokine, Feb 2015
Activin A and its receptor, ACVR2A, have been extensively studied in this regard.
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer.
Jung et al., Chicago, United States. In Mol Cancer, 2014
METHOD: Mitogenic signaling/growth factor receptor status and p21 localization were correlated in primary colon cancers and intestinal tumors from either AOM/DSS treated ACVR2A (activin receptor 2) -/- or wild type mice.
Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle.
Sugimoto et al., Fukushima, Japan. In Bmc Genet, 2014
RESULTS: We found that 2 variants, namely a single-nucleotide polymorphisms (SNP; g.48476925C > T) and a 3-bp indel (g.48476943_48476946insGGC), in the upstream region of the activin receptor IIA gene (ACVR2A) were associated with ANAI4.
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.
Impact
Moura et al., Paris, France. In Nat Med, 2014
We report that RAP-011, an activin receptor IIA (ActRIIA) ligand trap, improved ineffective erythropoiesis, corrected anemia and limited iron overload in a mouse model of β-thalassemia intermedia.
Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases.
Review
Katoh, Tokyo, Japan. In Front Cell Dev Biol, 2013
ACVR2A, BCL2, CCND1, E2F3, GLUT3, MYB, RAF1, VEGF, WEE1, and WNT7A are representative miR-195 targets.
Expression of inhibin/activin proteins and receptors in the human hypothalamus and basal forebrain.
GeneRIF
Stopa et al., Providence, United States. In J Neuroendocrinol, 2012
Activin type IIA receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain.
Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within activin receptor 2 (ACVR2).
GeneRIF
Carethers et al., San Diego, United States. In Mutat Res, 2012
Exonic selectivity for frameshift mutation within ACVR2 is specifically controlled by individual nucleotides flanking each coding ACVR2 microsatellite.
Activin A stimulates mouse macrophages to express APRIL via the Smad3 and ERK/CREB pathways.
GeneRIF
Kim et al., Ch'unch'ŏn, South Korea. In Immunol Lett, 2011
stimulates expression of APRIL via the Smad3 and ERK/CREB pathways in macrophages
Identification of Acvr2a as a Th17 cell-specific gene induced during Th17 differentiation.
GeneRIF
Kim et al., Chinju, South Korea. In Biosci Biotechnol Biochem, 2010
Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg.
Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells.
GeneRIF
Luo et al., Chongqing, China. In Acta Biochim Biophys Sin (shanghai), 2010
Results demonstrated that BMPRII and ActRII are the functional type II TGF-beta receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 cells.
Different phenotypes for mice deficient in either activins or activin receptor type II.
Impact
Bradley et al., Houston, United States. In Nature, 1995
To test the function of the type II activin receptor (ActRcII) in mammalian development and reproduction, we generated a null mutation in the ActRcII gene in mice using embryonic stem cell technology.
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