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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Secreted frizzled-related protein 1

SFRP1, Activin, FRP, SFRP4, EDF
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] (from NCBI)
Papers using SFRP1 antibodies
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
Lane Nancy E et al., In Journal of Bone and Mineral Research, 2007
... sFRP1 transgenic mice (Tg) PCR product ...
Papers on SFRP1
Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.
Schneyer et al., Springfield, United States. In Am J Physiol Endocrinol Metab, 2012
No differences were observed in fasting glucose/insulin levels, glucose tolerance, insulin sensitivity, or insulin secretion in comparing young or older males on in comparing insulin secretion from islets of wild type or activin B knockout males.
Identification of follistatin-like 1 by expression cloning as an activator of the growth differentiation factor 15 gene and a prognostic biomarker in acute coronary syndrome.
Wollert et al., Hannover, Germany. In Clin Chem, 2012
identified FSTL1 as an independent prognostic biomarker in ACS.
High levels of activin A detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting nodal signaling.
Wang et al., Chaoyang, China. In J Clin Endocrinol Metab, 2012
Plasma and placental productions of Activin A were significantly higher in preeclamptic patients when compared with normal pregnant subjects in a Chinese Han population
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Single nucleotide polymorphisms in sFRP4 are associated with bone and body composition related parameters in Danish but not in Belgian men.
Van Hul et al., Antwerp, Belgium. In Mol Genet Metab, 2012
genetic variation in sFRP4 has an influence on hip fracture risk, percentage body fat and height in a Danish male population. However, we were unable to replicate these results in an independent Belgian population.
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