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proteins. Page last changed on 08 Dec 2016.
Secreted frizzled-related protein 1
SFRP1, Activin, FRP, SFRP4, EDF
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] (from
Schneyer et al., Springfield, United States. In Am J Physiol Endocrinol Metab, 2012
No differences were observed in fasting glucose/insulin levels, glucose tolerance, insulin sensitivity, or insulin secretion in comparing young or older males on in comparing insulin secretion from islets of wild type or activin B knockout males.
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Van Hul et al., Antwerp, Belgium. In Mol Genet Metab, 2012
genetic variation in sFRP4 has an influence on hip fracture risk, percentage body fat and height in a Danish male population. However, we were unable to replicate these results in an independent Belgian population.