GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Inhibin, beta E
activin betaE, INHBE
INHBE is a member of the activin beta family (see INHBA; MIM 147290) that plays a role in pancreatic exocrine cell growth and proliferation (Hashimoto et al., 2006 [PubMed 16426570]).[supplied by OMIM, May 2008] (from
NCBI)
Top mentioned proteins:
SFRP1, TGF-beta, CAN, POLYMERASE, fibrillin-1
Papers on
activin betaE
Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.
New
Lund, Sweden. In J Cancer Res Clin Oncol, Feb 2015
Pancreatic disease link associations could be made for BAZ2A, CDK13, DAPK1, DST, EXOSC3, INHBE, KAT2B, KIF20B, SMC1B, and SPAG5, by pathway network linkages to p53, the most frequently altered tumor suppressor in pancreatic cancer.
Genome-wide association study for inhibin, luteinizing hormone, insulin-like growth factor 1, testicular size and semen traits in bovine species.
Australia. In Andrology, 2013
Based on these associations, INHBE, INHBC and HELB are proposed as candidate genes for IN regulation.
The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia.
Suita, Japan. In Schizophr Res, 2013
We found that ZNF804A-overexpression up-regulated four genes (ANKRD1, INHBE, PIK3AP1, and DDIT3) and down-regulated three genes (CLIC2, MGAM, and BIRC3).
Inhibin/activin betaE-subunit in uterine endometrioid adenocarcinoma and endometrial cancer cell lines: from immunohistochemistry to clinical testing?
München, Germany. In Gynecol Oncol, 2011
Additionally, the inhibin/activin betaE-subunit was found to be expressed in the human endometrial carcinoma cell lines HEC1a, HEC1b, Ishikawa, and RL95-2, although the level of expression was found to be highly differing among the cancer cell lines tested.
Inhibin/activin-betaE subunit is expressed in normal and pathological human placental tissue including chorionic carcinoma cell lines.
München, Germany. In Arch Gynecol Obstet, 2011
BACKGROUND: Inhibins and activins are important regulators of the female reproductive system.
NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells.
Adelaide, Australia. In J Bone Miner Res, 2010
Under osteoinductive conditions, BEZ235 strongly promotes osteogenic differentiation, as evidenced by an increase in mineralized matrix production, an upregulation of genes involved in osteogenesis, including bone morphogenetic proteins (BMP2, -4, and -6) and transforming growth factor β1 (TGF-β1) superfamily members (TGFB1, TGFB2, and INHBE), and increased activation of SMAD signaling molecules.
Inhibin/activin-betaC and -betaE subunits in the Ishikawa human endometrial adenocarcinoma cell line.
GeneRIF
München, Germany. In Arch Gynecol Obstet, 2010
Expression of the inhibin betaC and betaE subunits was demonstrated at the protein level and at the transcriptional level in normal human endometrial tissue and in the Ishikawa human endometrial carcinoma cell line.
Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells.
Philadelphia, United States. In Am J Hum Genet, 2010
Two of these are VLDLR and INHBE, which showed significant increase in expression after ER stress in B cells and in primary fibroblasts.
Evidence of inhibin/activin subunit betaC and betaE synthesis in normal human endometrial tissue.
GeneRIF
München, Germany. In Reprod Biol Endocrinol, 2009
differential expression pattern of the betaC- and betaE-subunits in normal human endometrial tissue suggests that they function in endometrial maturation and blastocyst implantation.
Inhibin/activin-betaE subunit in normal and malignant human cervical tissue and cervical cancer cell lines.
GeneRIF
München, Germany. In J Mol Histol, 2009
An immunolabelling of the inhibin-betaE subunit in normal and malignant cervical tissue, as well as cervical cancer cells, is demonstrated.
Implication of activin E in glucose metabolism: transcriptional regulation of the inhibin/activin betaE subunit gene in the liver.
Aomori, Japan. In Life Sci, 2009
AIMS: Activin E is a newly identified member of the transforming growth factor-beta superfamily.
Gene expression of the TGF-beta family in rat brain infected with Borna disease virus.
Sagamihara, Japan. In Microbes Infect, 2009
(1) BDV infection, irrespective of the variant, up-regulates TGF-beta1 expression in the brain, (2) the expressions of signal receptors for TGF-beta1 are also increased, (3) the expression of brain inhibin/activin betaE is up-regulated by BDV infection, and (4) the expression of brain inhibin/activin betaC tends to be higher in rats exhibiting severe Borna disease.
Development and characterisation of an antibody for the immunohistochemical detection of inhibin/activin betaE (betaE) in normal human ovarian and placental tissue.
München, Germany. In Acta Histochem, 2008
Inhibin/activin subunits are homologues to each other and belong to the transforming growth factor-beta (TGF-beta) family of proteins.
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).
Review
Japan. In Int J Mol Med, 2008
GLI activators then upregulate CCND1, CCND2 for cell cycle acceleration, FOXA2, FOXC2, FOXE1, FOXF1, FOXL1, FOXP3, POU3F1, RUNX2, SOX13, TBX2 for cell fate determination, JAG2, INHBC, and INHBE for stem cell signaling regulation.
Genetic variation in the inhibin pathway and risk of testicular germ cell tumors.
Rockville, United States. In Cancer Res, 2008
Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped.
Deregulation of the activin/follistatin system in hepatocarcinogenesis.
GeneRIF
Vienna, Austria. In J Hepatol, 2006
Follistatin was overexpressed while both activin subunits were downregulated in the majority of rat and human liver tumours
Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.
GeneRIF
Aomori, Japan. In Biochem Biophys Res Commun, 2006
activin E has a role in regulating the proliferation of pancreatic exocrine cells
Rat activin-betaE mRNA expression during development and in acute and chronic liver injury.
Australia. In J Mol Genet Med, 2005
Activin-betaE mRNA expression was investigated in male and female rats using gel-based and quantitative RT-PCR, in fetal and post-natal liver during development and in a variety of tissues from 200 gm adult animals.
Studying TGF-beta superfamily signaling by knockouts and knockins.
Review
Houston, United States. In Mol Cell Endocrinol, 2001
Two liver-specific activins, activin betaC and activin betaE are dispensable for liver development, regeneration and function, whereas ubiquitously expressed Smad5 has specific roles in the development of multiple embryonic and extraembryonic tissues.
