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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inhibin beta-A

activin A
subunit which can homodimerize or heterodimerize with Inhbb to regulate FSH secretion [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: SFRP1, CAN, follistatin, HAD, V1a
Papers using activin A antibodies
Patient-specific induced pluripotent stem-cell models for long-QT syndrome
Supplier
Wu Qiang, In PLoS ONE, 2009
... (Invitrogen #11905-031, 1∶100), 5–10 ng/ml FGF2 (Peprotech #100-18B), 0.5 ng/ml TGFβ1 (Peprotech #100-21C), 2.5–5 ng/ml Activin A (R&D #1066-AB-005 or eBioscience #14-8993-62), 50 nM DM ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
Hummler Edith et al., In Nature Communications, 2003
... Overexpression of activin A in the skin of transgenic mice reveals new activities ...
FACS purification of bone marrow-derived epidermal populations in mice: Langerhans cells and Thy-1+ dendritic cells
Supplier
Werner Sabine et al., In Nature Communications, 1984
... Overexpression of activin A in the skin of transgenic mice reveals new activities ...
Papers on activin A
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
New
Impact
Azim Surani et al., Kōbe, Japan. In Nature, Feb 2016
We investigated this in an in vitro model, in which naive pluripotent embryonic stem (ES) cells cultured in basic fibroblast growth factor (bFGF) and activin A develop as epiblast-like cells (EpiLCs) and gain competence for a PGC-like fate.
The Sertoli cell as the orchestra conductor of spermatogenesis: spermatogenic cells dance to the tune of testosterone.
Review
New
Sofikitis et al., In Hormones (athens), Feb 2016
Activin A, follistatin and FSH control germ cell development.
Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice.
New
Babitt et al., Reggio nell'Emilia, Italy. In Endocrinology, Feb 2016
Here, we show that low concentrations of Activin B, but not Activin A, stimulate prolonged SMAD1/5/8 signaling and hepcidin expression in liver cells to a similar degree as canonical SMAD2/3 signaling, and with similar or modestly reduced potency compared with BMP6.
Activin A and follistatin during the oestrous cycle and early pregnancy in ewes.
New
Juengel et al., New Zealand. In J Endocrinol, Feb 2016
The mRNAs encoding FST and activin A (inhibin beta A subunit, INHBA) were present in the uterus and abundant in the uterine luminal or glandular epithelia by day 18 of gestation.
Atypical Activin A and IL-10 Production Impairs Human CD16+ Monocyte Differentiation into Anti-Inflammatory Macrophages.
New
Sánchez-Torres et al., Mexico. In J Immunol, Feb 2016
The preferential proinflammatory skewing of M16 relative to M14 was found to be mediated by the secretion of activin A and the low levels of IL-10 produced by M16.
Effects of induced pluripotent stem cells-derived conditioned medium on the proliferation and anti-apoptosis of human adipose-derived stem cells.
New
Chen et al., Guangzhou, China. In Mol Cell Biochem, Feb 2016
The levels of Activin A and bFGF in culture supernatant of hASCs with different treatments were also detected by enzyme-linked immunosorbent assay.
The potential role of activin and follistatin in lung transplant dysfunction.
Review
New
Snell et al., Melbourne, Australia. In Expert Rev Respir Med, Dec 2015
Activin A, a member of the transforming growth factor β super-family, is a key regulator of multiple biological pathways including the physiological processes of organ development and homeostasis; as well as the pathological processes of inflammation, remodelling and fibrosis.
Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects.
Review
New
Grünig et al., Lincoln, United Kingdom. In Hum Mutat, Dec 2015
Specifically, studies have confirmed activin A receptor type II-like 1 (ACVRL1), endoglin (ENG), and members of the SMAD family as contributing to PAH both with and without associated clinical phenotypes.
The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
New
Young et al., Kuala Lumpur, Malaysia. In Sci Rep, Dec 2015
The present study identifies novel signalling properties for this integral membrane protein via the induction and secretion of activin A and TGFβ1, which are both required for LMP1's ability to induce the expression of the extracellular matrix protein, fibronectin.
Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid.
Review
New
Li et al., Handan, China. In Clin Chim Acta, Nov 2015
In early diagnosis of neonatal HIE, S-100β and activin A seems to be better biomarkers.
Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma.
Review
Clézardin et al., Athens, Greece. In Bonekey Rep, 2014
Inhibitors of cathepsin K, Src and activin A are under clinical investigation as potential anti-osteolytics.
On the difficulty of increasing dental complexity.
Impact
Jernvall et al., Helsinki, Finland. In Nature, 2012
We cultured teeth in vitro and adjusted ectodysplasin (EDA), activin A and sonic hedgehog (SHH) pathways, all of which are individually required for normal tooth development.
Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.
Impact
Dalton et al., Athens, United States. In Cell Stem Cell, 2012
When active, PI3K/Akt establishes conditions where Activin A/Smad2,3 performs a pro-self-renewal function by activating target genes, including Nanog.
The effects of FSH and activin A on follicle development in vitro.
GeneRIF
Drummond et al., Australia. In Reproduction, 2012
A stimulatory role of ActA in the primordial to primary and preantral stages of follicle development, suggesting an inhibitory action of activin on oocyte apoptosis.
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.
Review
Impact
Brown et al., Houston, United States. In Endocr Rev, 2011
Conversely, TGF-β and activin A inhibit adipocyte development, a process augmented in TGF-β-treated cells by Smads 6 and 7, negative regulators of canonical TGF-β signaling.
Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling.
GeneRIF
Hedger et al., Melbourne, Australia. In Mol Cell Endocrinol, 2011
TNFalpha and IL1alpha stimulates activin A secretion and expression in rat Sertoli cells
Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats.
GeneRIF
Oertel et al., New York City, United States. In Gastroenterology, 2011
Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats.
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells.
Impact
Schöler et al., Münster, Germany. In Cell Stem Cell, 2010
Mouse epiblast stem cells (EpiSCs) are cultured with FGF2 and Activin A, like human embryonic stem cells (hESCs), but the action of the associated pathways in EpiSCs has not been well characterized.
Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade.
GeneRIF
Diedrich et al., Lübeck, Germany. In Fertil Steril, 2010
Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of MAD homolog 2 (Drosophila) (Smad2) protein, Smad3, and Smad4 in vitro.
Regulation of interleukin 1alpha, activin and inhibin by lipopolysaccharide in Sertoli cells from prepubertal rats.
GeneRIF
Hedger et al., Melbourne, Australia. In Mol Cell Endocrinol, 2009
Bacterial lipopolysaccharide increased the production of interleukin 1alpha and activin A, and reduced production of inhibin B, in Sertoli cells from immature male rats.
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