Development of New Therapeutic Agents for Fibrodysplasia Ossificans Progressiva.
Pomona, United States. In Curr Mol Med, Dec 2015
The causative heterozygous genetic mutations have been identified in either the intracellular glycine-serine-rich (GS) domain or kinase domain of ALK2 (Activin-like kinase-2, also known as Activin A receptor type I, ACVR1), a type I receptor of bone morphogenetic proteins (BMP).
The potential role of activin and follistatin in lung transplant dysfunction.
Melbourne, Australia. In Expert Rev Respir Med, Dec 2015
Activin A, a member of the transforming growth factor β super-family, is a key regulator of multiple biological pathways including the physiological processes of organ development and homeostasis; as well as the pathological processes of inflammation, remodelling and fibrosis.
On the difficulty of increasing dental complexity.
Helsinki, Finland. In Nature, 2012
We cultured teeth in vitro and adjusted ectodysplasin (EDA), activin A and sonic hedgehog (SHH) pathways, all of which are individually required for normal tooth development.