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ACT1 Act1p

Actin, ACT1
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009] (from NCBI)
Papers using Actin antibodies
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
Methner Axel et al., In Journal of Neuroinflammation, 2010
... the anti-Nrf2 antibody was from Santa Cruz Biotechnology, Bergheimer Straße 89, 69115 Heidelberg, Germany; the anti-Actin antibody and secondary antibodies were from Millipore, 290 Concord Road Billerica, MA 01821, USA; the anti-NF-κB-antibody was from Cell Signaling Technologies, 3 Trask Lane Danvers, ...
Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1
Singh Lalit P. et al., In Experimental Diabetes Research, 2010
... and HMGB1 are from Santa Cruz Biotechnology (Santa Cruz, CA), and VDUP1 (TXNIP), tubulin, and Actin were from Abcam (Cambridge, MA) ...
mTORC1 signaling: what we still don’t know
Tajmir-Riahi Heidar-Ali, In PLoS ONE, 2010
... and 4E-BP-1 were obtained from Cell Signaling (New England Biolabs, Hertfordshire, UK), and antibody against β-Actin, anti-rabbit IgG-horseradish peroxidase-conjugated secondary antibody, and anti-mouse IgG-horseradish peroxidase-conjugated secondary antibody were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
Leverkus Martin et al., In The Journal of Cell Biology, 2008
... β-Actin antibodies were purchased from Sigma-Aldrich, and HRP-coupled monoclonal antibody to GFP was purchased from Clontech.
Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice
Sohn Uy Dong et al., In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2008
... phospho-SAPK/JNK, SAPK/JNK, phospho-p38 MAPK, and p38 MAPK antibodies from Cell Signaling Technology (Beverly, MA, USA); Actin antibody from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
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Papers on Actin
CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis.
Siebenlist et al., Bethesda, United States. In J Immunol, 2012
A CIKS mutant may promote the initiation of psoriatic inflammation
Direct redox regulation of F-actin assembly and disassembly by Mical.
Terman et al., Dallas, United States. In Science, 2012
actin filament subunits were directly modified by Mical on their conserved pointed-end, critical for filament assembly; Mical posttranslationally oxidized the methionine 44 residue within D-loop of actin, severing filaments and decreasing polymerization
Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly.
Holak et al., Martinsried, Germany. In Proc Natl Acad Sci U S A, 2012
Data suggest that the molecular and structural mechanism of actin polymerization by Spire should apply to other actin-binding proteins that contain WH2 domains in tandem.
A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation.
Li et al., Cleveland, United States. In Sci Signal, 2010
Data show that deletion of the CC' loop from Act1 or IL-17RA abolished the interaction between both proteins.
Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.
Qian et al., Shanghai, China. In Sci Signal, 2010
Data indicate that knockdown of beta-TrCP1 and beta-TrCP2 markedly reduced IL-17-induced, phosphorylation-dependent ubiquitination and degradation of Act1.
More papers using Actin antibodies
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Dieli Francesco, In PLoS ONE, 2008
... of cytokine signaling 3 (SOCS3), proliferating cell nuclear antigen (PCNA), phosphoinositide 3-kinases 85α (PI3K85α), PI3K110α and Actin antibody were obtained from Santa Cruz Biotechnology, Inc ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... ], mouse anti-importin β1 (3E9; Dianova), mouse anti-myc (9E10; Santa Cruz Biotechnology), rabbit anti-beta Actin (ab8227; Abcam), goat anti-GST (GE Healthcare) ...
Enhanced recovery from contraction-induced damage in skeletal muscles of old mice following treatment with the heat shock protein inducer 17-(allylamino)-17-demethoxygeldanamycin
Chang Jang-Yang et al., In Molecular Cancer, 2007
... The antibodies used in this study included a mouse anti-Actin antibody (Santa Cruz Biotechnology, Santa Cruz, CA), a rabbit ...
To reg or not to reg: that is the question in COPD.
Idzko Marco, In PLoS ONE, 2007
... mouse anti-human Cytokeratin 18 (Pierce), mouse anti-human E-cadherin (Dako), mouse anti-human Smooth Muscle Actin (Dako; M0851), and mouse anti-human ...
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation
Vale Ronald D. et al., In The Journal of Cell Biology, 2007
... Actin-GFP was obtained from Clontech Laboratories, Inc ...
Precancerous stem cells can serve as tumor vasculogenic progenitors.
Bridger Joanna Mary, In PLoS ONE, 2007
... Mouse anti-β-Actin (1∶1,000) and mouse anti-Tubulin (1∶2,000) antibodies were purchased from Santa Cruz Biotechnology Inc ...
p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis
Bhat Manoj K et al., In Cell & Bioscience, 2006
... mouse monoclonal), E6 (goat polyclonal and mouse monoclonal), GAPDH (goat polyclonal), β-Tubulin (rabbit polyclonal) and β-Actin (goat polyclonal) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.
Jin Dong-Yan, In PLoS ONE, 2006
... Other antibodies used were anti-myc (9E10), anti-FLAG (M2), anti-HA (12CA5), and β-Actin (Cell signaling technology) ...
Induced pluripotent stem cell lines derived from human somatic cells
Kasahara Noriyuki et al., In Molecular Therapy. Nucleic Acids, 2006
... β-Actin primary antibody (ab8227; Abcam, Cambridge, MA) was used ...
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase.
Cordes Nils, In PLoS ONE, 2006
... (Abcam; and gift from Pam Silver, Dana-Farber Cancer Institute), anti-GFP mouse monoclonal antibody (Santa Cruz), anti-Actin mouse monoclonal antibody (Sigma), anti-α-Tubulin rabbit polyclonal antibody (Abcam), anti-E-cadherin antibody, anti-β-catenin antibody, ...
Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response?
Cleary Margot P et al., In Breast Cancer Research : BCR, 2006
... β-Actin was purchased from Delta Biolabs, LLC (Gilroy, CA, USA) ...
Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics
Bertozzi Carolyn R. et al., In ACS Chemical Biology, 2005
... α-Actin clone C4 was obtained from AbCAM.
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of Rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells.
Blagosklonny Mikhail V., In PLoS ONE, 2005
... Antibodies were obtained as follows: anti-p-Tyr-EGFR1173/p-Tyr1248, p-Tyr-Src 416, p-Tyr-SHP2, and β-Actin were all obtained from Cell Signaling Technology Inc (Danvers, MA) ...
Unidirectional Notch signaling depends on continuous cleavage of Delta.
Rutherford Suzannah, In PLoS ONE, 2004
... , Hunchback (gift from Paul MacDonald), Kruppel (gift from John Reinitz), Pericardin (EC11, DSHB), or Actin (Abcam, ab49846), following standard protocols ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Barillé-Nion Sophie et al., In Breast Cancer Research : BCR, 2004
... Antibodies to Bax and Actin were from Dako (Trappes, France) and Millipore, ...
Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer
Cho Myung-Haing et al., In International Journal of Nanomedicine, 2003
... Bax, Bcl-xL, proliferating cell nuclear antigen (PCNA), Cyclin B1, vascular endothelial growth factor (VEGF), and Actin antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Navarro Alfons, In PLoS ONE, 2003
... anti-CD31, anti-VEGF, anti-MMP-2, anti-MMP-9 and anti-Actin antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells.
Callaerts Patrick, In PLoS ONE, 2003
... Actin-GFP transgenic mice C57BL/6-Tg(ACTbEGFP)10sb/J were purchased ...
Equine estrogens differentially prevent cell death induced by glutamate
Bhavnani Bhagu R et al., In BMC Neuroscience, 2002
... ) and goat polyclonal antibody to Actin (sc1616) from Santa Cruz Biotechnology, Inc (Santa Cruz, Ca) ...
ErbB2/neu kinase modulates cellular p27Kip1 and cyclin D1 through multiple signaling pathways
Penichet Manuel L et al., In Breast Cancer Research : BCR, 2000
... β-Actin antibody (ab8226) was purchased from Abcam Inc ...
A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission.
Grimes H. Leighton, In PLoS Genetics, 1996
... High contribution chimeras were subsequently crossed to Actin-flpe transgenic mice ...
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
Yang Bo et al., In Journal of Biomedicine and Biotechnology, 1996
... -Actin, and HRP-labeled secondary antigoat, antimouse, and antirabbit antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation.
Cordes Nils, In PLoS ONE, 1995
... Monoclonal anti-FLNa (Chemicon), monoclonal anti-vinculin antibody (Sigma), monoclonal anti-Actin (Abcam) polyclonal anti-GFP (Rockland), polyclonal ...
Endogenous beta-galactosidase activity in the larval, pupal, and adult stages of the fruit fly, Drosophila melanogaster, indicates need for caution in lacZ fusion-gene studies
Monesi Nadia et al., In BMC Molecular Biology, 1995
... Actin), 30 μg of total RNA extracted from 3 h prepupae of the (-57/+40) transgenic line were hybridized either ...
Homology modelling of the catalytic domain of human furin: A model for the eukaryotic subtilisin-like proprotein convertases.
Antopolsky Maxim, In PLoS ONE, 1993
... The primary and secondary antibodies for PDGF-B, Actin and FLAG tag were bought from Santa Cruz Biotechnology Inc (Santa Cruz, Ca, ...
Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402
Neumann Carola A et al., In The EMBO Journal, 1992
... (110B7E) and HA-tag were purchased from Cell Signaling; Antibodies recognizing PTEN (A2B1), PTEN (N-19) and Actin (C-11) were purchased from Santa Cruz; antibodies against Prdx1 and Prdx1-SO2/-SO3 were purchased from Abcam; Ras antibody from Oncogene; ...
Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach
Ekblom Peter et al., In Journal of Negative Results in Biomedicine, 1990
... cDNA probes used: a 935 bp PCR generated GP210 probe (nt 4286–5220), a 1.8 kb human β-Actin control probe (Clontech) and a 1023 bp PCR ...
Spontaneous remission of solar keratoses: the case for conservative management.
Santos Janine, In PLoS ONE, 1985
... We used primary antibodies against Ser 1981-phosphorylated ATM (Rockland), ATM (Abcam), Lamin A (Abcam), Actin (Abcam) and Giantin Golgi marker ...
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Mohammad Ramzi M et al., In Molecular Cancer, 1983
... Primary antibody specific for Actin was obtained from Santa Cruz Biotechnology, (Santa Cruz, CA) ...
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