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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Melanocortin 2 receptor

ACTH receptor, MC2R, melanocortin 2 receptor, ACTH-R, adrenocorticotropin receptor
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, MC5R, CAN, ACID, proopiomelanocortin
Papers on ACTH receptor
Identifying the activation motif in the N-terminal of rainbow trout and zebrafish melanocortin-2 receptor accessory protein 1 (MRAP1) orthologs.
New
Vijayan et al., Denver, United States. In Gen Comp Endocrinol, Feb 2016
UNASSIGNED: The activation of mammalian melanocortin-2 receptor (MC2R) orthologs is dependent on a four-amino acid activation motif (LDYL/I) located in the N-terminal of mammalian MRAP1 (melanocortin-2 receptor accessory protein).
Adrenocortical endocrine disruption.
Review
New
Harvey, Harrogate, United Kingdom. In J Steroid Biochem Mol Biol, Jan 2016
Further, every step in the adrenocortical steroidogenic pathway (ACTH receptor, StAR, CYP's 11A1, 17, 21, 11B1, 11B2, and 3-hydroxysteroid dehydrogenase Δ4,5 isomerase) is known to be a potential target with multiple examples of chemicals inhibiting these targets.
Maternal programming of offspring hypothalamic-pituitary-interrenal axis in wild sockeye salmon (Oncorhynchus nerka).
New
Hinch et al., Vancouver, Canada. In Gen Comp Endocrinol, Jan 2016
However, resting levels of POA glucocorticoid receptors (GR1 and GR2), and head kidney melanocortin 2 receptor (MC2R), steroidogenic acute regulatory protein (StAR), and cytochrome P450 side chain cleavage enzyme (P450scc) were elevated in offspring reared from stressor-exposed females.
Differential expression of feeding-related hypothalamic neuropeptides in the first generation of quails divergently selected for low or high feed efficiency.
New
Dridi et al., Fayetteville, United States. In Neuropeptides, Jan 2016
Indeed, the expression of NPY, POMC, CART, CRH, melanocortin system (MC1R, MC2R, MC4R, MC5R), ORX, mTOR and ACCα was significantly decreased, however ORXR1/2, AMPKα1, S6K1 and STAT1, 5 and 6 were increased in high compared to low FE males (P<0.05).
Primary Adrenocortical Insufficiency Case Series: Genetic Etiologies More Common than Expected.
New
Curtis et al., St. John's, Canada. In Horm Res Paediatr, Jan 2016
One had a homozygous MC2R mutation associated with familial glucocorticoid deficiency.
Assessment of Protein Expression by Proximity Ligation Assay in the Nonhuman Primate Endometrium, Placenta, and Fetal Adrenal in Response to Estrogen.
New
Albrecht et al., United States. In Methods Mol Biol, Dec 2015
We describe herein the PLA method and its applicability to quantify the effects of estrogen on expression of angioregulatory factors, e.g., angiopoietin-1 (Ang-1) in the endometrium, vascular endothelial growth factor (VEGF) in the placenta, and melanocortin 2 receptor (MC2R)/accessory protein (MRAP) in the fetal adrenal of the nonhuman primate.
Relative contribution of P450c17 towards the acute cortisol response: Lessons from sheep and goats.
Review
New
Swart et al., Stellenbosch, South Africa. In Mol Cell Endocrinol, Jul 2015
The rapid release of cortisol from the adrenal cortex upon ACTH receptor activation plays an integral role in the stress response.
Views on the co-evolution of the melanocortin-2 receptor, MRAPs, and the hypothalamus/pituitary/adrenal-interrenal axis.
Review
New
Garcia et al., Denver, United States. In Mol Cell Endocrinol, Jul 2015
A critical regulatory component of the hypothalamus/pituitary/adrenal axis (HPA) in mammals, reptiles and birds, and in the hypothalamus/pituitary/interrenal (HPI) axis of amphibians and teleosts (modern bony fishes) is the strict ligand selectivity of the melanocortin-2 receptor (MC2R).
Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature.
Review
New
Zada et al., In Neurosurg Focus, Feb 2015
Candidate genes/proteins found to be underexpressed in ACTH-PAs relative to the normal pituitary gland included CDKN1B/p27(Kip1), CDKN2A/p16, KISS1/kisspeptin, ACTHR/ACTH-R, and miR-493.
Melanocortin receptor accessory proteins in adrenal disease and obesity.
Review
Chan et al., London, United Kingdom. In Front Neurosci, 2014
MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
Impact
Majzoub et al., Boston, United States. In Science, 2013
To investigate the physiological role of brain-expressed melanocortin 2 receptor accessory protein 2 (MRAP2), we characterized mice with whole-body and brain-specific targeted deletion of Mrap2, both of which develop severe obesity at a young age.
Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research.
Review
Impact
Grässel et al., Münster, Germany. In Endocr Rev, 2012
MCR subtypes, especially MC1R, MC2R (the ACTH receptor), MC3R, and MC4R, but also the μ-OR and δ-OR, have been detected in various cells of the synovium, cartilage, and bone.
Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells.
GeneRIF
Ragolia et al., Mineola, United States. In Mol Cell Endocrinol, 2012
Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells.
[Association between plasma lipid, glucose, cortisol and adrenocorticotropic hormone levels and GR and ACTHR gene polymorphisms].
GeneRIF
Liu et al., Ürümqi, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
No significant difference was found between plasma lipid and glucose levels and various GR and ACTHR genotypes.
[Associations of GR and ACTHR gene polymorphisms with quantitative trait of strain].
GeneRIF
Liu et al., Ürümqi, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2011
GRA5556G, GRA5556G, GAGG4534/4536AAAG polymorphisms and ACTHR promoter T-2C variants might be associated with quantitative trait of stress.
Mechanisms of melanocortin-2 receptor (MC2R) internalization and recycling in human embryonic kidney (hek) cells: identification of Key Ser/Thr (S/T) amino acids.
GeneRIF
Gallo-Payet et al., Sherbrooke, Canada. In Mol Endocrinol, 2011
Intracellular Ser and Thr (S/T) residues of MC2R were found to play important roles not only in plasma membrane targeting and function but also in promoting receptor internalization.
Familial glucocorticoid deficiency in five Arab kindreds with homozygous point mutations of the ACTH receptor (MC2R): genotype and phenotype correlations.
GeneRIF
Rasoul et al., Kuwait, Kuwait. In Horm Res Paediatr, 2010
Familial glucocorticoid deficiency in five Arab kindreds with homozygous point mutations of the ACTH receptor (MC2R).
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.
Impact
Clark et al., London, United Kingdom. In Nat Genet, 2005
Mutations of the ACTH receptor (melanocortin 2 receptor, MC2R) account for approximately 25% of cases of FGD.
Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor.
Impact
Grossman et al., London, United Kingdom. In Lancet, 1993
We investigated the DNA base sequence in a family with this condition by polymerase chain reaction amplification of DNA with pairs of primers that span the ACTH-receptor domain.
Defensins: antimicrobial and cytotoxic peptides of mammalian cells.
Review
Impact
Ganz et al., Los Angeles, United States. In Annu Rev Immunol, 1992
In addition to their antimicrobial and cytotoxic properties, some defensins act as opsonins, while others inhibit protein kinase C, bind specifically to the ACTH receptor and block steroidogenesis or act as selective chemoattractants for monocytes.
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