Adrenocortical endocrine disruption.
Harrogate, United Kingdom. In J Steroid Biochem Mol Biol, Jan 2016
Further, every step in the adrenocortical steroidogenic pathway (ACTH receptor, StAR, CYP's 11A1, 17, 21, 11B1, 11B2, and 3-hydroxysteroid dehydrogenase Δ4,5 isomerase) is known to be a potential target with multiple examples of chemicals inhibiting these targets.
Differential expression of feeding-related hypothalamic neuropeptides in the first generation of quails divergently selected for low or high feed efficiency.
Fayetteville, United States. In Neuropeptides, Jan 2016
Indeed, the expression of NPY, POMC, CART, CRH, melanocortin system (MC1R, MC2R, MC4R, MC5R), ORX, mTOR and ACCα was significantly decreased, however ORXR1/2, AMPKα1, S6K1 and STAT1, 5 and 6 were increased in high compared to low FE males (P<0.05).
Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research.
Münster, Germany. In Endocr Rev, 2012
MCR subtypes, especially MC1R, MC2R (the ACTH receptor), MC3R, and MC4R, but also the μ-OR and δ-OR, have been detected in various cells of the synovium, cartilage, and bone.
Defensins: antimicrobial and cytotoxic peptides of mammalian cells.
Los Angeles, United States. In Annu Rev Immunol, 1992
In addition to their antimicrobial and cytotoxic properties, some defensins act as opsonins, while others inhibit protein kinase C, bind specifically to the ACTH receptor and block steroidogenesis or act as selective chemoattractants for monocytes.