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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Kallikrein-related peptidase 15

AcO, KLK15, kallikrein-like serine protease
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, PPAR, V1a, HAD
Papers on AcO
Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.
New
Hashimoto et al., Chiba, Japan. In Mol Psychiatry, Feb 2016
Furthermore, gene expression of two subtypes (IDH3A and IDH3B) of isocitrate dehydrogenase (IDH) in the dorsolateral prefrontal cortex from BD patients was significantly lower than that of controls, although the expression of other genes including, aconitase (ACO1, ACO2), IDH1, IDH2 and IDH3G, were not altered.
Recognition of halides and Y-shaped oxoanions by carbonylchromium-based urea-like molecules: A theoretical analysis of hydrogen bonding modes.
New
Sun et al., Shanghai, China. In J Mol Graph Model, Jan 2016
Our results suggest that the F(-) and AcO(-) anions are recognized experimentally due to a combination of strong interaction and large infrared (IR) shifts upon complexation, verifying the remarkable IR-reporting ability of the Cr(CO)3 moiety and its potential applications in anion recognition.
Design of Multichannel Osmium-Based Metalloreceptor for Anions and Cations by Taking Profit from Metal-Ligand Interaction and Construction of Molecular Keypad Lock and Memory Device.
New
Baitalik et al., Calcutta, India. In Inorg Chem, Jan 2016
The complex behaves as a bifunctional sensor for F(-), AcO(-), CN(-), Fe(2+), and Cu(2+) ions in acetonitrile, whereas it is a highly selective chromogenic chemosensor for only CN(-) and Fe(2+) ions in water.
A Cyanuric Acid Platform Based Tripodal Bis-heteroleptic Ru(II) Complex of Click Generated Ligand for Selective Sensing of Phosphates via C-H···Anion Interaction.
New
Ghosh et al., Calcutta, India. In Inorg Chem, Jan 2016
It shows selective sensing of hydrogen pyrophosphate (HP2O7(3-)) through 20-fold enhanced emission intensity (ϕf = 0.039) with a 15 nm red shift in emission maxima even in the presence of a large excess of various competitive anions like F(-), Cl(-), AcO(-), BzO(-), NO3(-), HCO3(-), HSO4(-), HO(-), and H2PO4(-) in acetonitrile.
Ant colony optimisation of decision tree and contingency table models for the discovery of gene-gene interactions.
Review
New
Frayling et al., Exeter, United Kingdom. In Iet Syst Biol, Dec 2015
In this study, ant colony optimisation (ACO) algorithm is used to derive near-optimal interactions between a number of single nucleotide polymorphisms (SNPs).
Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer.
New
Sharma-Walia et al., North Chicago, United States. In Oncotarget, Dec 2015
Surprisingly, the expression of lipogenic pathway genes including SREBP-1c (sterol regulatory element-binding protein-1c), HMG-CoA synthase, SPTLC1 (serine palmitoyltransferase long-chain), and Acyl-CoA oxidase (ACO) decreased with a concurrent increase in fatty acid oxidation genes such as CPT-1a (carnitine palmitoyltransferase 1a) and SREBP-2 (Sterol regulatory element-binding protein-2).
Pseudomonas putida attunes morphophysiological, biochemical and molecular responses in Cicer arietinum L. during drought stress and recovery.
New
Nautiyal et al., Lucknow, India. In Plant Physiol Biochem, Dec 2015
Quantitative real-time (qRT)-PCR analysis showed differential expression of genes involved in transcription activation (DREB1A and NAC1), stress response (LEA and DHN), ROS scavenging (CAT, APX, GST), ethylene biosynthesis (ACO and ACS), salicylic acid (PR1) and jasmonate (MYC2) signalling in both chickpea cultivars exposed to drought stress and recovery in the presence or absence of RA.
Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae.
Hou et al., Guangzhou, China. In J Biomed Sci, 2014
Moreover, caffeine treatment was associated with upregulation of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1).
The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis.
Review
Kamp et al., Chicago, United States. In Int J Mol Sci, 2014
We focus on the emerging role for AEC mtDNA damage repair by 8-oxoguanine DNA glycosylase (OGG1) and mitochondrial aconitase (ACO-2) in maintaining mtDNA integrity which is important in preventing AEC apoptosis and asbestos-induced pulmonary fibrosis in a murine model.
Mechanism of Butyrate Stimulation of Triglyceride Storage and Adipokine Expression during Adipogenic Differentiation of Porcine Stromovascular Cells.
Ajuwon et al., West Lafayette, United States. In Plos One, 2014
Although increased ACO gene expression was seen with butyrate treatment, experiments with the peroxisomal fatty acid inhibitor, thioridazine, suggest that butyrate may have an inhibitory effect on peroxisomal fatty acid oxidation.
Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice.
Chao et al., Taiwan. In Molecules, 2014
Furthermore, the expression of inflammatory proteins, such as iNOS and NF-κB, was suppressed via activated PPARγ, and the expression levels of GPx3 and ACO increased.
Intracellular redistribution of acetyl-CoA, the pivotal point in differential susceptibility of cholinergic neurons and glial cells to neurodegenerative signals.
Review
Pawełczyk et al., Gdańsk, Poland. In Biochem Soc Trans, 2014
The inhibition of PDHC, ACO (aconitase) and KDHC (ketoglutarate dehydrogenase complex) activities by neurodegenerative signals such as aluminium, zinc, amyloid β-peptide, excess nitric oxide (NO) or thiamine pyrophosphate deficits resulted in much deeper losses of viability, acetyl-CoA and ATP in differentiated cholinergic neuronal cells than in non-differentiated cholinergic, and cultured microglial or astroglial cell lines.
Predictions for the future of kallikrein-related peptidases in molecular diagnostics.
Review
Mavridis et al., Athens, Greece. In Expert Rev Mol Diagn, 2014
The present report provides an overview of the biomarker potential of the extended KLK family (KLK1-KLK15) in various disease settings and envisages approaches that could lead to additional KLK-driven applications in future molecular diagnostics.
Kallikrein-related peptidases in cancers of gastrointestinal tract: an inside view of their role and clinical significance.
Review
Zografos et al., Athens, Greece. In J Buon, 2014
Human tissue kallikrein (KLK1) and is related peptidases (KLK2-KLK15) are a family of 15 homologous serine proteases, participating in numerous processes of normal physiology.
A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.
GeneRIF
Clements et al., Brisbane, Australia. In Bmc Cancer, 2010
association with ovarian cancer survival
Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.
GeneRIF
Spurdle et al., Brisbane, Australia. In Plos One, 2010
These findings suggest a role for KLK15 genetic variation in the etiology of prostate cancer among men of European ancestry.
KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy.
GeneRIF
Stephan et al., Berlin, Germany. In Int J Cancer, 2010
Multivariate analysis identified dichotomised KLK15 expression, corrected for patient parameters age, preoperative prostate-specific antigen level, pathological tumour stage, Gleason score and surgical margins, as an prognostic factor for poor outcome.
Expression analysis and study of the KLK15 mRNA splice variants in prostate cancer and benign prostatic hyperplasia.
GeneRIF
Scorilas et al., Athens, Greece. In Cancer Sci, 2010
KLK15 expression analysis could be employed as a valuable tool for the discrimination between benign prostatic hyperplasia and prostate cancer tissue specimens and as an unfavorable prognostic marker for prostate cancer.
A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.
GeneRIF
Amundadottir et al., Gaithersburg, United States. In Hum Genet, 2010
Data show six non-synonymous amino acid or frame shift changes in the KLK3 gene and three changes in each of the neighboring genes, KLK15 and KLK2.
Prognostic value of the human kallikrein gene 15 expression in ovarian cancer.
Impact
GeneRIF
Diamandis et al., Toronto, Canada. In J Clin Oncol, 2003
KLK15 expression, as assessed by quantitative RT-PCR, is an independent marker of unfavorable prognosis for ovarian cancer.
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