A sphingolipid mechanism for behavioral extinction.
Düsseldorf, Germany. In J Neurochem, Feb 2016
Rapid extinction, indicating efficient re-learning, coincided with a decrease in the activity of the enzyme acid sphingomyelinase (ASM), which catalyzes turnover of sphingomyelin to ceramide, in the dorsal hippocampus (DH) of rats.
Sphingolipids in Major Depression.
Essen, Germany. In Neurosignals, Jan 2016
We have recently discovered that an inhibition of the acid sphingomyelinase/ceramide system mediates the effects of tri- and tetracyclic antidepressants.
Role of sphingomyelinases in neurological disorders.
Singapore, Singapore. In Expert Opin Ther Targets, Dec 2015
AREAS COVERED: We covered an introduction to sphingomyelinases and its enzymatic product ceramide, in membrane domains or lipid rafts and the nucleus; followed by crosstalk between sphingomyelinase and cytosolic phospholipase A2 (cPLA2) catalysed products including arachidonic acid, functions of acid sphingomyelinase (aSMase) and neutral sphingomyelinase (N-SMase) in neurons, neuronal progenitor cells, glial cells, and brain endothelial cells; alterations in acid and N-SMases in Niemann Pick Disease Type A, major depression, Alzheimer's disease, cerebral ischemia, and pain; and recent developments in identification of inhibitors to sphingomyelinases.
Types A and B Niemann-Pick disease.
New York City, United States. In Best Pract Res Clin Endocrinol Metab, Mar 2015
The first is due to the deficient activity of the enzyme acid sphingomyelinase (ASM).
It takes a CAD to kill a tumor cell with a LMP.
Essen, Germany. In Cancer Cell, 2013
In this issue of Cancer Cell, Petersen and colleagues show that lysosomal sphingomyelin content determines LMP and cationic drugs displace acid sphingomyelinase from lysosomal membranes, increasing tumor LMP and death.