A sphingolipid mechanism for behavioral extinction.
Düsseldorf, Germany. In J Neurochem, Feb 2016
Rapid extinction, indicating efficient re-learning, coincided with a decrease in the activity of the enzyme acid sphingomyelinase (ASM), which catalyzes turnover of sphingomyelin to ceramide, in the dorsal hippocampus (DH) of rats.
The emerging role of acid sphingomyelinase in autophagy.
Milano, Italy. In Apoptosis, May 2015
An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase (A-SMase), already known to play a fundamental role in apoptotic cell death participating in several pathophysiological conditions.
Types A and B Niemann-Pick disease.
New York City, United States. In Best Pract Res Clin Endocrinol Metab, Mar 2015
The first is due to the deficient activity of the enzyme acid sphingomyelinase (ASM).
It takes a CAD to kill a tumor cell with a LMP.
Essen, Germany. In Cancer Cell, 2013
In this issue of Cancer Cell, Petersen and colleagues show that lysosomal sphingomyelin content determines LMP and cationic drugs displace acid sphingomyelinase from lysosomal membranes, increasing tumor LMP and death.