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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sphingomyelin phosphodiesterase 1, acid lysosomal

acid sphingomyelinase, NPD, ASMase
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, PrP
Papers on acid sphingomyelinase
A sphingolipid mechanism for behavioral extinction.
Müller et al., Düsseldorf, Germany. In J Neurochem, Feb 2016
Rapid extinction, indicating efficient re-learning, coincided with a decrease in the activity of the enzyme acid sphingomyelinase (ASM), which catalyzes turnover of sphingomyelin to ceramide, in the dorsal hippocampus (DH) of rats.
The structure and catalytic mechanism of Human Sphingomyelin Phosphodiesterase like 3a - an acid sphingomyelinase homolog with a novel nucleotide hydrolase activity.
Nordlund et al., Singapore, Singapore. In Febs J, Feb 2016
UNASSIGNED: Human sphingomyelinase phosphodiesterase like 3a (SMPDL3a) is a secreted enzyme that shares a conserved catalytic domain with human acid sphingomyelinase (aSMase), the enzyme carrying mutations causative of Niemann Pick disease.
Screening and Characterization of Genes Involved in the Processing of Lipid-Containing Droplets in C. elegans Embryos.
Döring et al., Kiel, Germany. In Genetics, Feb 2016
The genes include cpl-1 (cathepsin L-like cysteine protease), ccz-1 (guanine nucleotide exchange factor subunit), and asm-3 (acid sphingomyelinase), which is closely related to the human Niemann-Pick disease-causing gene, SMPD1.
Host Sphingomyelin Increases West Nile Virus Infection in vivo.
Saiz et al., Spain. In J Lipid Res, Feb 2016
After infection with the neurotropic WNV, mice deficient in acid sphingomyelinase (ASM), which accumulate high levels of sphingomyelin in their tissues, displayed exacerbated infection.
Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161.
Robson et al., Nanchang, China. In Purinergic Signal, Sep 2015
CD39 and CD161 have direct interactions that are further linked with acid sphingomyelinase (ASM).
A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression.
Kornhuber et al., Essen, Germany. In J Neurochem, Jul 2015
These concepts suggest that the acid sphingomyelinase/ceramide system plays a central role in the pathogenesis of major depression and may be a novel target for anti-depressants.
The emerging role of acid sphingomyelinase in autophagy.
Clementi et al., Milano, Italy. In Apoptosis, May 2015
An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase (A-SMase), already known to play a fundamental role in apoptotic cell death participating in several pathophysiological conditions.
Types A and B Niemann-Pick disease.
Wasserstein et al., New York City, United States. In Best Pract Res Clin Endocrinol Metab, Mar 2015
The first is due to the deficient activity of the enzyme acid sphingomyelinase (ASM).
Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats.
Mei et al., Hangzhou, China. In Biomed Res Int, 2014
They were then equally randomized to three groups: NPD group, LPD group, and LPD + KA group.
Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.
Fernández-Checa et al., Barcelona, Spain. In Redox Biol, 2013
An important process mediating the mitochondrial disruption induced by alcohol intake is the trafficking of cholesterol to mitochondria, mediated by acid sphingomyelinase-induced endoplasmic reticulum stress, which contributes to increased cholesterol synthesis and StARD1upregulation.
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.
Jäättelä et al., Copenhagen, Denmark. In Cancer Cell, 2013
Here, we identify acid sphingomyelinase (ASM) inhibition as a selective means to destabilize cancer cell lysosomes.
It takes a CAD to kill a tumor cell with a LMP.
Kolesnick et al., Essen, Germany. In Cancer Cell, 2013
In this issue of Cancer Cell, Petersen and colleagues show that lysosomal sphingomyelin content determines LMP and cationic drugs displace acid sphingomyelinase from lysosomal membranes, increasing tumor LMP and death.
Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.
Kornhuber et al., Essen, Germany. In Nat Med, 2013
We investigated the role of the acid sphingomyelinase (Asm)-ceramide system as a target for antidepressants.
TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species.
Ramakrishnan et al., Seattle, United States. In Cell, 2013
TNF-induced necroptosis occurs through two pathways: modulation of mitochondrial cyclophilin D, implicated in mitochondrial permeability transition pore formation, and acid sphingomyelinase-mediated ceramide production.
Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection.
Davey et al., Galveston, United States. In J Virol, 2012
work suggests that ASMase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus.
A novel SMPD1 mutation in two Chinese sibling patients with type B Niemann-Pick disease.
Wang et al., Shanghai, China. In Chin Med J (engl), 2012
One mutation V36A due to c.107T>C in exon 1 is a single nucleotide polymorphism and the other N522S due to c.1565 A>G in exon 6 is a novel missense mutation
Neonatal screening for lysosomal storage disorders: feasibility and incidence from a nationwide study in Austria.
Kasper et al., Vienna, Austria. In Lancet, 2012
Anonymised samples were analysed for enzyme activities of acid β-glucocerebrosidase, α-galactosidase, α-glucosidase, and acid sphingomyelinase by electrospray ionisation tandem mass spectrometry.
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Marí et al., Barcelona, Spain. In J Biol Chem, 2012
a functional relationship between ASMase and CtsB and that the ablation of ASMase leads to the enhanced processing and activation of CtsB.
Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E(-/-) mice.
Yew et al., Framingham, United States. In J Gene Med, 2011
Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E knockout mice.
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
Hannun et al., Charleston, United States. In J Biol Chem, 2011
cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5.
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