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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Deoxyribonuclease II, lysosomal

acid DNase, DNASE2, DNase IIalpha, Deoxyribonuclease IIalpha
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on acid DNase
Homozygosity for DNASE2 single nucleotide polymorphisms in the 5'-regulatory region is associated with rheumatoid arthritis.
GeneRIF
Wagner et al., Leipzig, Germany. In Ann Rheum Dis, 2009
The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with Rheumatoid Arthritis implies a role for this enzyme in the pathogenesis of this autoimmune disease.
Human lysosomal DNase IIalpha contains two requisite PLD-signature (HxK) motifs: evidence for a pseudodimeric structure of the active enzyme species.
GeneRIF
Meiss et al., Gie├čen, Germany. In Protein Sci, 2007
the enzyme is a monomeric phospholipase D-family member with a pseudodimeric protein fold
Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells.
GeneRIF
Lu et al., Taipei, Taiwan. In Eur J Biochem, 2003
Sp1 and Sp3 are involved in up-regulation of this enzyme's transcriptoin during cell differentiation of hl-60 cells.
Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells.
GeneRIF
Lu et al., Taipei, Taiwan. In Biochem Biophys Res Commun, 2002
upregulation of expression during myelomonocytic differentiation of HL-60 and THP-1 cells
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