ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.
New York City, United States. In Nat Med, Oct 2015
We establish that persistent upregulation of the ACF (ATP-utilizing chromatin assembly and remodeling factor) ATP-dependent chromatin-remodeling complex, occurring in the nucleus accumbens of stress-susceptible mice and depressed humans, is necessary for stress-induced depressive-like behaviors.
Williams syndrome is an epigenome-regulator disease.
Tokyo, Japan. In Endocr J, 2010
This novel ATP-dependent chromatin remodeling complex facilitates VDR-mediated transrepression as well as transactivation with its ATP-dependent chromatin remodeling activity and promoter targeting property for the activator to access to the DNA.
The role of INI1/hSNF5 in gene regulation and cancer.
Toronto, Canada. In Biochem Cell Biol, 2009
In this review, we discuss a core subunit of the SWI/SNF ATP-dependent chromatin remodeling complex, known as INI1/hSNF5, in the context of transcriptional regulation and impact on cancer biology.