Acetylcholinesterase Inhibitors for Delirium in Older Adults.
Hartford, United States. In Am J Alzheimers Dis Other Demen, Jan 2016
OBJECTIVES: The aim of this systematic review is to identify published randomized controlled trials (RCTs) that evaluated the use of acetylcholinesterase inhibitors for delirium in older adults (≥60 years).
Organophosphate pesticide exposure and neurodegeneration.
Almería, Spain. In Cortex, Nov 2015
Apart from the principle action of OPs which involves inhibition of the acetylcholinesterase (AChE) enzyme, several molecular targets, such as hormones; neurotransmitters; neurotrophic factors; enzymes related to the metabolism of beta amyloid protein as well as inflammatory changes have been identified for OP compounds.
Automated design of ligands to polypharmacological profiles.
Dundee, United Kingdom. In Nature, 2013
The method is demonstrated by the evolution of an approved acetylcholinesterase inhibitor drug into brain-penetrable ligands with either specific polypharmacology or exquisite selectivity profiles for G-protein-coupled receptors.
Chemically engineered extracts: source of bioactive compounds.
Rosario, Argentina. In Acc Chem Res, 2011
We isolated a semisynthetic β-glucosidase inhibitor from a CEE prepared by reaction with benzenesulfonyl chloride, an antifungal pyrazole from a CEE prepared by reaction with hydrazine, and an acetylcholinesterase inhibitor from a CEE prepared through bromination.