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Scavenger receptor class F, member 1

acetyl-LDL receptor, SREC, SREC-I
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, CD36, LOX-1
Papers on acetyl-LDL receptor
The SREC-I and SREC-II associated with epidermal growth factor in scavenger receptor family are the potential regulative transmembrane receptors in Larimichthys crocea.
New
Liu et al., Zhoushan, China. In Fish Shellfish Immunol, Nov 2015
In this study, the SREC-I and SREC-II of SCARFs in Larimichthys crocea (designated as LycSREC1 and LycSREC2 respectively) were first identified, the potential genetic locus relationships with other species were depicted and the features of gene expression after Vibrio alginolyticus stimulation were tested.
Emerging roles for scavenger receptor SREC-I in immunity.
Review
New
Calderwood et al., Boston, United States. In Cytokine, Oct 2015
SREC-I is a class F scavenger receptor with key role in the immune response, particularly in antigen presenting cell (APC) such as macrophages and dendritic cells (DC).
Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes.
New
Calderwood et al., Boston, United States. In Immunobiology, Jun 2015
Scavenger receptor associated with endothelial cells (SREC-I) was previously shown to be expressed by immune cells and to play a role in CD8(+)-mediated T cell immunity.
Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae.
New
Rudel et al., Würzburg, Germany. In Cell Microbiol, Feb 2015
Gonococci associated with DGI mainly express the outer membrane protein PorBIA that binds to the scavenger receptor expressed on endothelial cells (SREC-I) and mediates bacterial uptake.
Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I.
Calderwood et al., Boston, United States. In Immunobiology, 2014
Earlier studies had suggested that mice immunized with a molecular chaperone-based vaccine derived from tumors became immune to further vaccination and that both CD8(+) and CD4(+) T cells were activated by the chaperone vaccine in a manner dependent on scavenger receptor SREC-I.
The alpha-fetoprotein third domain receptor binding fragment: in search of scavenger and associated receptor targets.
Review
Mizejewski, Albany, United States. In J Drug Target, 2014
The scavenger receptors (SRs) identified were CD36, CD163, Stabilin, SSC5D, SRB1 and SREC; the SR-associated receptors included the mannose, low-density lipoprotein receptors, the asialoglycoprotein receptor, and the receptor for advanced glycation endproducts (RAGE).
Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages.
Józefowski et al., Kraków, Poland. In Plos One, 2014
Other scavenger receptors, SREC-I and LOX-1, as well as RAGE were also able to bind HOCl-modified proteins, but they did not contribute significantly to these ligands uptake by dendritic cells because they were either not expressed or exhibited preference for more heavily oxidised proteins.
Scavenger receptor SREC-I mediated entry of TLR4 into lipid microdomains and triggered inflammatory cytokine release in RAW 264.7 cells upon LPS activation.
Calderwood et al., Porto Alegre, Brazil. In Plos One, 2014
Scavenger receptor associated with endothelial cells I (SREC-I) was shown to be expressed in immune cells and to play a role in the endocytosis of peptides and antigen presentation.
SR-A and SREC-I binding peptides increase HDAd-mediated liver transduction.
Brunetti-Pierri et al., Napoli, Italy. In Gene Ther, 2014
We investigated two small peptides (PP1 and PP2) developed by phage display to block scavenger receptor type A (SR-A) and scavenger receptor expressed on endothelial cells type I (SREC-I), respectively, for enhancement of HDAd-mediated hepatocyte transduction efficiency.
The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).
GeneRIF
Zlabinger et al., Vienna, Austria. In Cell Immunol, 2010
GP2 is a binding partner of the scavenger receptor expressed on endothelial cells I (SREC-I) but not of SR-AI and SR-BI. Dendritic cells express SREC-I and also bind and internalize GP2.
Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I.
GeneRIF
Calderwood et al., Boston, United States. In J Immunol, 2010
SREC-I mediated internalization of Hsp90-ovalbumin polypeptide complexes through an endocytic pathway known as the glycosylphosphatidylinositol-anchored protein-enriched early endosomal compartment to recycling endosomes.
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.
GeneRIF
El Khoury et al., United States. In J Exp Med, 2009
CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.
Extracellular heat shock proteins in cell signaling and immunity.
Review
Gray et al., Boston, United States. In Ann N Y Acad Sci, 2007
Such receptors include toll- like receptors (TLRs) 2 and 4, CD40, CD91, CCR5, and members of the scavenger receptor family, such as LOX-1 and SREC-1.
Scavenger receptor expressed by endothelial cells (SREC)-I interacts with protein phosphatase 1alpha in L cells to induce neurite-like outgrowth.
GeneRIF
Tsujimoto et al., Wako, Japan. In Biochem Biophys Res Commun, 2007
Our system may be useful for the elucidation of the mechanism of morphological maturation of neuronal cells such as dorsal root ganglion neurons that express SREC-I during early development.
Extracellular heat shock proteins in cell signaling.
Review
Theriault et al., Boston, United States. In Febs Lett, 2007
Such receptors include Toll Like Receptors 2 and 4, CD40, CD91, CCR5 and members of the scavenger receptor family such as LOX-1 and SREC-1.
Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.
Impact
Mantovani et al., Saint-Pierre-des-Corps, France. In Immunity, 2005
KpOmpA binds the scavenger receptors (SRs) LOX-1 and SREC-I, but not other members of the same family.
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.
Impact
Hengartner et al., Stony Brook, United States. In Nature, 2005
In the second group, the candidate receptor CED-1 (CD91/LRP/SREC) probably recognizes an unknown ligand on the apoptotic cell and signals via its cytoplasmic tail to the adaptor protein CED-6 (hCED-6/GULP), whereas CED-7 (ABCA1) is thought to play a role in membrane dynamics.
Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth.
GeneRIF
Arai et al., Tokyo, Japan. In J Biol Chem, 2004
interaction of SREC-I and advillin are involved in the development of dorsal root ganglion neurons by inducing the described morphological changes.
CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.
Impact
Horvitz et al., Cambridge, United States. In Cell, 2001
ced-1 encodes a transmembrane protein similar to human SREC (Scavenger Receptor from Endothelial Cells).
Scavenger receptors and oxidized low density lipoproteins.
Review
Steinbrecher et al., Vancouver, Canada. In Clin Chim Acta, 1999
This article provides an overview of the characterization and functions of the scavenger receptors that have been shown to interact with oxidized LDL, including SR-AI/II, CD36, SR-BI, macrosialin/CD68, LOX-1, and SREC.
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