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CSR1 acetolactate synthase

Acetolactate Synthase, acetohydroxyacid synthase, csr1
Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis. Requires FAD, thiamine pyrophosphate and Mg. Inhibited by the sulphonylurea herbicide, chlorsulphuron, and the imidazolinone herbicide, imazapyr. The obtained crystal structure of acetohydroxyacid synthase AHAS, EC 2.2.1.6)in complex with herbicides of the sulphonylurea and imidazolinone family reveals the molecular basis for substrate/inhibitor binding. (from NCBI)
Top mentioned proteins: Als, ACID, CAN, STEP, HAD
Papers on Acetolactate Synthase
Molecular basis of multiple resistance to ACCase- and ALS-inhibiting herbicides in Alopecurus japonicus from China.
New
Wang et al., China. In Pestic Biochem Physiol, Jan 2016
Growers have resorted to using mesosulfuron-methyl, an acetolactate synthase (ALS)-inhibiting herbicide, to control this weed.
Temperature-dependent acetoin production by Pyrococcus furiosus is catalyzed by a biosynthetic acetolactate synthase and its deletion improves ethanol production.
New
Adams et al., Athens, United States. In Metab Eng, Jan 2016
A novel type of acetolactate synthase (ALS), which is involved in branched-chain amino acid biosynthesis, is responsible and deletion of the als gene abolishes acetoin production.
Bi-allelic gene targeting in rice.
New
Toki et al., Tsukuba, Japan. In Plant Physiol, Jan 2016
To synchronize DSB induction and delivery of the HDR template, we transformed a Cas9 expression construct and GT vector harboring the HDR template with gRNAs targeting the rice acetolactate synthase (ALS) gene either separately or sequentially into rice calli.
Optimization of expression and properties of the recombinant acetohydroxyacid synthase of Thermotoga maritima.
New
Ma et al., Waterloo, Canada. In Data Brief, Dec 2015
The data provide additional support of the characterization of the biophysical and biochemical properties of the enzyme acetohydroxyacid synthase from the hyperthermophilic bacterium Thermotoga maritima (Eram et al., 2015) [1].
Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241.
New
Shen et al., China. In Sci Rep, Dec 2015
Four encoding genes were assembled into E. coli with budA (acetolactate decarboxylase) and budB (acetolactate synthase), responsible for converting pyruvate into acetoin.
Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation.
New
Honda et al., Suita, Japan. In Plos One, Dec 2015
Acetolactate synthase and pyruvate decarboxylase are thiamine pyrophosphate-dependent enzymes that convert pyruvate into acetolactate and acetaldehyde, respectively.
Expression of flavonoid 3',5'-hydroxylase and acetolactate synthase genes in transgenic carnation: assessing the safety of a nonfood plant.
Review
Tanaka et al., Portugal. In J Agric Food Chem, 2014
The transgenic carnation carries a herbicide tolerance gene (a mutant gene encoding acetolactate synthase (ALS)) and has been modified to produce delphinidin-based anthocyanins in flowers, which conventionally bred carnation cannot produce.
SCARA3 mRNA is overexpressed in ovarian carcinoma compared with breast carcinoma effusions.
GeneRIF
Davidson et al., Oslo, Norway. In Hum Pathol, 2012
The consistently high SCARA3 levels in both primary carcinomas and metastatic cells in effusions, and its up-regulation along disease progression from diagnosis to recurrence, suggest a role in ovarian cancer biology.
Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides.
GeneRIF
Langel et al., Stockholm, Sweden. In Faseb J, 2012
Results demonstrate the involvement of SCARA3 and SCARA5 in the uptake of PF14-oligonucleotide nanocomplexes.
Bacterial acetohydroxyacid synthase and its inhibitors--a summary of their structure, biological activity and current status.
Review
Yoon et al., Seoul, South Korea. In Febs J, 2012
Acetohydroxyacid synthase (anabolic AHAS; EC 2.2.1.6)
Herbicide resistances in Amaranthus tuberculatus: a call for new options.
Review
Hager et al., Urbana, United States. In J Agric Food Chem, 2011
Herbicides to which A. tuberculatus has evolved resistance are photosystem II inhibitors, acetolactate synthase inhibitors, protoporphyrinogen oxidase inhibitors, and glyphosate.
Amino acids conferring herbicide resistance in tobacco acetohydroxyacid synthase.
Review
Tran et al., Tsukuba, Japan. In Gm Crops, 2010
Acetohydroxyacid synthase (AHAS) (EC 4.1.3.18) is a target of commercially available herbicides such as sulfonylurea, imidazolinone, and triazolopyrimidine.
High-frequency modification of plant genes using engineered zinc-finger nucleases.
Impact
Voytas et al., Ames, United States. In Nature, 2009
Here we demonstrate high-frequency ZFN-stimulated gene targeting at endogenous plant genes, namely the tobacco acetolactate synthase genes (ALS SuRA and SuRB), for which specific mutations are known to confer resistance to imidazolinone and sulphonylurea herbicides.
Crops with target-site herbicide resistance for Orobanche and Striga control.
Review
Gressel, Israel. In Pest Manag Sci, 2009
Such target-site resistances have allowed foliar applications of herbicides inhibiting enol-pyruvylshikimate phosphate synthase (EPSPS) (glyphosate), acetolactate synthase (ALS) (e.g.
CSR1 induces cell death through inactivation of CPSF3.
GeneRIF
Luo et al., Pittsburgh, United States. In Oncogene, 2009
CSR1 appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme CPSF3.
SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion.
GeneRIF
Régnacq et al., Poitiers, France. In Biochem J, 2008
Sfh2p inhibits fatty acid synthase activity in response to haem depletion
Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast.
GeneRIF
Bankaitis et al., Chapel Hill, United States. In Biochem Soc Trans, 2006
This review describes how overexpression of Sec14p-like protein SFH2 (Sec Fourteen Homologue 2) rescues sec14-1(temperature-sensitive)-associated growth and secretory defects.
Tobacco ribosomal DNA spacer element stimulates amplification and expression of heterologous genes.
Impact
Raskin et al., New Brunswick, United States. In Nat Biotechnol, 2000
Transgenic tobacco plants, transformed with expression cassettes containing the herbicide-resistant acetolactate synthase (hr-ALS) gene or the green fluorescent protein (GFP) gene fused to the aps sequence, had greater levels of corresponding messenger RNAs (mRNAs) and proteins compared to transformants lacking aps.
Engineering herbicide-resistant maize using chimeric RNA/DNA oligonucleotides.
Impact
Baszczynski et al., Mangochi, Malawi. In Nat Biotechnol, 2000
A precise single-point mutation was introduced into genes encoding acetohydroxyacid synthase (AHAS), at a position known to confer imidazolinone resistance.
Acetolactate synthase is the site of action of two sulfonylurea herbicides in higher plants.
Impact
Mauvais et al., In Science, 1984
Biochemical and genetic studies of a tobacco mutant resistant to the herbicides chlorsulfuron and sulfometuron methyl have demonstrated that these sulfonylurea herbicides inhibit acetolactate synthase, the first enzyme specific to the branched chain amino acid biosynthetic pathway.
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