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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Angiotensin I converting enzyme

ACE2, angiotensin-converting enzyme 2, Ace2p
enzyme peptidyl-dipeptidase; mouse homolog has a role in regulation of cardiac contractility and regulating Angiotensin 1 and 2 levels [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Angiotensin II, Renin, MAS, AT1, CAN
Papers using ACE2 antibodies
Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats
Supplier
Burns Kevin D et al., In Kidney International, 2006
... Human ACE2 transgenic protein is present as ...
Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries
Supplier
Jones E. S. et al., In International Journal of Hypertension, 2003
... R, and ACE2 (Santa Cruz Biotechnology Inc., Catalogue no ...
Papers on ACE2
Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?
Review
New
Chappell, Winston-Salem, United States. In Am J Physiol Heart Circ Physiol, Feb 2016
In contrast, the nonclassical RAS composed primarily of the ANG II/ANG III-AT2R and the ACE2-ANG-(1-7)-AT7R pathways generally opposes the actions of a stimulated ANG II-AT1R axis.
Resistance training prevents the cardiovascular changes caused by high-fat diet.
New
Colombari et al., São Paulo, Brazil. In Life Sci, Feb 2016
The anti-inflammatory interleukin-10, angiotensin type 2 receptor, Mas receptor and angiotensin converting enzyme 2 mRNA expressions in the NTS increased in the RT-HFD compared to SED-HFD.
Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.
New
Krause et al., United States. In Neuropharmacology, Feb 2016
Angiotensin converting enzyme (ACE2) inhibits RAS activity by converting angiotensin II, the effector peptide of RAS, to angiotensin-(1-7), which activates Mas receptors (MasR).
Isolation and characterization of a novel bat coronavirus closely related to the direct progenitor of SARS coronavirus.
New
Shi et al., Wuhan, China. In J Virol, Jan 2016
Cell entry and susceptibility studies indicated that this virus can use ACE2 as receptor and infect animal and human cell lines.
Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae.
New
Wei et al., South Bend, United States. In Biotechnol Biofuels, Dec 2015
The top TFs identified, Sfp1p and Ace2p, were experimentally tested as overexpression targets for strain optimization.
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
New
Impact
Baric et al., Chapel Hill, United States. In Nat Med, Dec 2015
The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV.
Diminazene aceturate-An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
Review
New
de Freitas et al., Teresina, Brazil. In Pharmacol Res, Dec 2015
It was thus possible to highlight several researches that have investigated alternatives in order to improve success in the treatment of animal trypanosomiasis, by using new drugs in associations with diminazene aceturate, as well as looking for new pharmacological applications for this compound, such as leishmanicidal, amebicidal, anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent, and mainly as an activator of angiotensin-converting enzyme 2. Another pharmacological property still little studied is the inhibition of acid-sensitive ion channels (ASIC1a, ASIC1b, ASIC2a and ASIC3), which are related to the development of various diseases.
Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCA/NaCl-Induced Hypertension in Female Rats.
New
He et al., Shenyang, China. In Oxid Med Cell Longev, Dec 2015
However, the mRNA expressions of antihypertensive components such as AT2-R, ACE-2, and IL-10 were increased only in intact females.
The Role of Renin Angiotensin Aldosterone System Genes in Diabetic Nephropathy.
Review
New
Rahimi, Kermānshāh, Iran. In Can J Diabetes, Dec 2015
Further, the concomitant study of both systemic and local RAAS, counter-regulators of ACE and ACE2, and also AT1R and angiotensin II type 2 receptor (AT2R) genes could help to elucidate the role of the genes of this system in the pathogenesis of DN.
Brain angiotensin-(1-7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress.
Review
New
Santos et al., Belo Horizonte, Brazil. In Neuropeptides, Nov 2015
On the other hand, growing evidence indicates that its counterregulatory axis, the angiotensin-converting enzyme 2 (ACE2)/(Ang)iotensin-(1-7)/Mas axis, reduces anxiety and attenuates the physiological responses to emotional stress.
Perspectives for angiotensin profiling with liquid chromatography/mass spectrometry to evaluate ACE/ACE2 balance in endothelial dysfunction and vascular pathologies.
Review
New
Smolenski et al., Gdańsk, Poland. In Pharmacol Rep, Aug 2015
However, recent discovery of angiotensin converting enzyme 2 (ACE2) that produces vasoprotective Ang-(1-7) peptide highlighted complexity of the system and suggested that balance between ACE/Ang II and ACE2/Ang-(1-7) is fundamental in maintaining vascular homeostasis and its disorders are associated with cardiovascular pathology.
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.
Impact
Shi et al., Wuhan, China. In Nature, 2013
Diverse SARS-like coronaviruses (SL-CoVs) have now been reported from bats in China, Europe and Africa, but none is considered a direct progenitor of SARS-CoV because of their phylogenetic disparity from this virus and the inability of their spike proteins to use the SARS-CoV cellular receptor molecule, the human angiotensin converting enzyme II (ACE2).
Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions.
GeneRIF
Burrell et al., Melbourne, Australia. In Clin Sci (lond), 2012
Data suggest that strategies that do augment angiotensin-converting enzyme 2 (ACE2) after myocardial infarction (MI) may be a useful addition to standard renin-angiotensin system blockade after MI.
Upregulation of ACE2-ANG-(1-7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport.
GeneRIF
Leung et al., Hong Kong, Hong Kong. In Am J Physiol Endocrinol Metab, 2012
Data suggest that jejunal enterocyte protein and mRNA expression of ACE2 and Mas receptor are up-regulated in type 1 diabetes.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Impact
GeneRIF
Penninger et al., Vienna, Austria. In Nature, 2012
deficiency in murine angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), which encodes a key regulatory enzyme of the renin-angiotensin system (RAS), results in highly increased susceptibility to intestinal inflammation induced by epithelial damage
Nuclear envelope morphology constrains diffusion and promotes asymmetric protein segregation in closed mitosis.
GeneRIF
Barral et al., Zürich, Switzerland. In J Cell Biol, 2012
show that Ace2 asymmetry is initiated in the elongated, but undivided, anaphase nucleus
ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.
GeneRIF
Zhong et al., Shanghai, China. In Plos One, 2011
ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.
The spike protein of SARS-CoV--a target for vaccine and therapeutic development.
Review
Impact
Jiang et al., New York City, United States. In Nat Rev Microbiol, 2009
The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes.
Essential role for collectrin in renal amino acid transport.
Impact
Penninger et al., Vienna, Austria. In Nature, 2007
Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals.
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