A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
Chapel Hill, United States. In Nat Med, Dec 2015
The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV.
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.
Wuhan, China. In Nature, 2013
Diverse SARS-like coronaviruses (SL-CoVs) have now been reported from bats in China, Europe and Africa, but none is considered a direct progenitor of SARS-CoV because of their phylogenetic disparity from this virus and the inability of their spike proteins to use the SARS-CoV cellular receptor molecule, the human angiotensin converting enzyme II (ACE2).
Essential role for collectrin in renal amino acid transport.
Vienna, Austria. In Nature, 2007
Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals.