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ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

ACAP2, KIAA0041, centaurin-beta2
Top mentioned proteins: ARF6, GAP, p16, ACAP1, Rab5
Papers using ACAP2 antibodies
A requirement for Arf6 in Fcγ receptor-mediated phagocytosis in macrophages
Supplier
Randazzo Paul A. et al., In The Journal of Cell Biology, 1997
... ACAP2 was cloned from a SuperScript human leukocyte cDNA library (Life Technologies) using a 2-kb KpnI fragment ...
Papers on ACAP2
Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells.
New
Fukuda et al., Sendai, Japan. In J Biol Chem, May 2015
We previously showed that Rab35 promotes neurite outgrowth of nerve growth factor-stimulated PC12 cells through interaction with centaurin-β2 (also called ACAP2).
Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells.
Espinosa et al., Boulder, United States. In Cell Cycle, 2014
We report here that ACAP2, a homolog of C. elegans CNT-1, has a pro-apoptotic function and an identical phosphoinositide-binding pattern to that of tCNT-1, despite not being an apparent target of caspase cleavage.
Activation-Inactivation Cycling of Rab35 and ARF6 Is Required for Phagocytosis of Zymosan in RAW264 Macrophages.
Araki et al., Japan. In J Immunol Res, 2014
Moreover, the simultaneous expression of ACAP2-a Rab35 effector protein-with GTP-locked Rab35 or the expression of plasma membrane-targeted ACAP2 showed a marked inhibitory effect on phagocytosis through ARF6 inactivation by the GAP activity of ACAP2.
Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination.
Yamauchi et al., Tokyo, Japan. In Mol Biol Cell, 2014
We show that Rab35 and its effector, ACAP2, a GTPase-activating protein that switches off Arf6 activity, negatively regulate oligodendrocyte morphological differentiation.
Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.
Fukuda et al., Sendai, Japan. In J Cell Sci, 2013
Rab35 forms a tripartite complex with MICAL-L1 and centaurin-β2/ACAP2 and recruits them to perinuclear Arf6-positive endosomes in response to nerve growth factor stimulation.
Genetic aberrations in imatinib-resistant dermatofibrosarcoma protuberans revealed by whole genome sequencing.
La Choi et al., Seoul, South Korea. In Plos One, 2012
Of note, we identified newly emerged 8 non-synonymous somatic mutations of the genes (ACAP2, CARD10, KIAA0556, PAAQR7, PPP1R39, SAFB2, STARD9, and ZFYVE9) in the imatinib-resistant tumor tissue.
RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate.
Grant et al., United States. In Proc Natl Acad Sci U S A, 2012
One RAB-10-binding partner that we identified, CNT-1, is the only C. elegans homolog of the mammalian Arf6 GTPase-activating proteins ACAP1 and ACAP2.
Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth.
GeneRIF
Fukuda et al., Sendai, Japan. In J Cell Sci, 2012
Rab35 regulates Arf6 activity through centaurin-beta2 (ACAP2) during neurite outgrowth.
Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis.
Araki et al., Japan. In J Cell Sci, 2011
Furthermore, GTP-Rab35-dependent recruitment of ACAP2, an ARF6 GTPase-activating protein, was shown in the phagocytic cup formation.
Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs.
Fukuda et al., Sendai, Japan. In Traffic, 2010
Three of the 21 Rab-binding proteins we identified, mKIAA1055/TBC1D2B (Rab22-binding protein), GAPCenA/TBC1D11 (Rab36-binding protein) and centaurin beta2/ACAP2 (Rab35-binding protein), are GTPase-activating proteins (GAPs) for Rab or Arf.
Substrate specificities and activities of AZAP family Arf GAPs in vivo.
GeneRIF
Casanova et al., Charlottesville, United States. In Am J Physiol Cell Physiol, 2008
ACAP2 has robust, constitutive Arf6 GAP activity in vivo, with little activity toward Arf1.
Vaccinia virus K1L protein supports viral replication in human and rabbit cells through a cell-type-specific set of its ankyrin repeat residues that are distinct from its binding site for ACAP2.
Xiang et al., San Antonio, United States. In Virology, 2006
These substitutions, however, did not affect K1L's ability to bind ACAP2, a GTPase-activating protein for ARF6.
Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein.
Terajima et al., Worcester, United States. In Virus Res, 2005
We also investigated the interaction of K1L protein with cellular proteins and found that K1L interacts with the rabbit homologue of human ACAP2, a GTPase-activating protein with ankyrin repeats.
DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.
Roberts et al., Boston, United States. In J Biol Chem, 2002
This degree of substrate preference was unique to DEF-1, as other ARF GAP proteins, ACAP1, ACAP2, and ARFGAP1, were able to function on both ARF1 and ARF6.
ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.
Randazzo et al., Bethesda, United States. In J Cell Biol, 2000
Here, we report the identification and characterization of two Arf6 GAPs, ACAP1 and ACAP2.
Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.
GeneRIF
Theibert et al., London, United Kingdom. In Trends Biochem Sci, 2000
Centaurin beta2/KIAA0041, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localisation and activity.
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