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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adenylate cyclase 8

AC8, adenylyl cyclase 8
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, OUT, AC3, HAD
Papers on AC8
N-Docosahexaenoylethanolamine ameliorates ethanol-induced impairment of neural stem cell neurogenic differentiation.
Kim et al., Bethesda, United States. In Neuropharmacology, Mar 2016
Ethanol-induced cAMP reduction was accompanied by the inhibition of G-protein activation and expression of adenylyl cyclase (AC) 7 and AC8, as well as PDE4 upregulation.
A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
Zhou et al., Changzhou, China. In Epilepsy Res, Jan 2016
Ca(2+)-stimualted adenylyl cyclase 8 (AC8) expressed in the CNS plays a role in synaptic plasticity, drug addiction and ethanol sensitivity, and chronic pain.
Store-operated Ca²⁺-entry and adenylyl cyclase.
Cooper, Cambridge, United Kingdom. In Cell Calcium, Oct 2015
The molecular basis for this dependence is now resolved in the case of adenylyl cyclase 8 (AC8).
Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.
Iwasato et al., Mishima, Japan. In Neuroscience, May 2015
In the third line, all calcium-stimulated adenylyl cyclases (both AC1 and AC8) are deleted in cortical excitatory neurons.
Multilevel control of glucose homeostasis by adenylyl cyclase 8.
Lang et al., Pessac, France. In Diabetologia, Apr 2015
Expression of the calcium-stimulated adenylyl cyclase ADCY8 is regulated by glucose and the enzyme is capable of integrating signals from multiple pathways.
Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A.
Wicksteed et al., Chicago, United States. In Mol Metab, Apr 2015
GLP-1R signaling systems were affected by hyperglycemia with increased expression of mRNAs encoding the inducible cAMP early repressor (ICER) and adenylyl cyclase 8, reduced PKA activity due to increased expression of the PKA-RIα subunit, reduced GLP-1R mRNA expression and loss of GLP-1R from the cell surface.
Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition.
Storm et al., Shanghai, China. In J Neurosci, Feb 2015
In contrast, AC1 and AC8 double knock-out mice are hypoactive, and exhibit increased sociability and reduced impulsivity.
The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat.
Terrar et al., Oxford, United Kingdom. In Front Physiol, 2014
Short (milliseconds or seconds) and long (minutes) term influences of calcium are discussed including direct regulation of ion channels and NCX, and control of the activity of calcium-dependent enzymes (including CaMKII, AC1, and AC8).
Transcriptional modulation of squalene synthase genes in barley treated with PGPR.
Ahmad et al., Lahore, Pakistan. In Front Plant Sci, 2014
The most efficient bacterial strain which recorded maximum gene expression was A. aceti AC8.
Effect of salinity on biomass yield and physiological and stem-root anatomical characteristics of purslane (Portulaca oleracea L.) accessions.
Abdul Hamid et al., Kuala Selangor, Malaysia. In Biomed Res Int, 2014
Considering salinity effect on purslane physiology, increase in chlorophyll content was seen in Ac2, Ac4, Ac6, and Ac8 at 16 dS m(-1) salinity, whereas Ac4, Ac9, and Ac12 showed increased photosynthesis at the same salinity levels compared to control.
Routes to cAMP: shaping neuronal connectivity with distinct adenylate cyclases.
Gaspar et al., Paris, France. In Eur J Neurosci, 2014
The implication of specific AC isoforms in neural wiring was only recently demonstrated in mouse mutants, knockout (KO) for different AC isoforms, AC1, AC3, AC5, AC8 and soluble (s)AC/AC10.
Regulation of nephron water and electrolyte transport by adenylyl cyclases.
Kohan et al., San Diego, United States. In Am J Physiol Renal Physiol, 2014
So far, nine distinct membrane-bound AC isoforms (AC1-9) and one soluble AC (sAC) have been identified and, except for AC8, all of them are expressed in the kidney.
Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
Burcin et al., Cambridge, United States. In Nat Cell Biol, 2012
Stimulation with glucose causes WFS1 translocation from the ER to the plasma membrane, where it forms a complex with adenylyl cyclase 8 (AC8), an essential cAMP-generating enzyme in the β-cell that integrates glucose and GLP-1 signalling.
The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.
Limon et al., Paris, France. In J Biol Chem, 2012
AC8 expression, besides being induced by the proinflammatory cytokine IL1beta, is also dependent on down-regulation of the Notch pathway occurring in an inflammatory context.
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Cooper et al., Cambridge, United Kingdom. In Sci Signal, 2012
Orai1 and AC8 binding mediates dynamic interplay between Ca2+ and cAMP signaling
The role of Ca²⁺-stimulated adenylyl cyclases in bidirectional synaptic plasticity and brain function.
Zhang et al., East Lansing, United States. In Rev Neurosci, 2011
Ca2+-stimulated type 1 and type 8 adenylyl cyclases (AC1 and AC8) are unique enzymes that couple activity-dependent calcium influx to the activation of cAMP signaling.
Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
Cooper et al., Cambridge, United Kingdom. In J Biol Chem, 2011
Mutation of the two critical cysteines results in exclusion of AKAP79 from lipid rafts and alterations in its membrane diffusion behavior and is accompanied by a loss of the ability of AKAP79 to regulate AC8.
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
Lang et al., Pessac, France. In Diabetologia, 2011
cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R.
Crosstalk between adenylyl cyclase signaling pathway and Ca2+ regulatory mechanism under red blood cell microrheological changes.
Batalova et al., Yaroslavl', Russia. In Clin Hemorheol Microcirc, 2009
Ca2+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered.
Regulation and role of adenylyl cyclase isoforms.
Defer et al., Créteil, France. In Annu Rev Pharmacol Toxicol, 2000
The present review deals with various aspects of such regulations, emphasizing the role of calcium/calmodulin in activating AC1 and AC8 in the central nervous system, the potential inhibitory effect of calcium on AC5 and AC6, and the changes in the expression pattern of the isoforms during development.
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