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Adenylate cyclase 4

AC4, Adcy4
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: AC3, HAD, CAN, ACID, OUT
Papers on AC4
Mapping and identification of cassava mosaic geminivirus DNA-A and DNA-B genome sequences for efficient siRNA expression and RNAi based virus resistance by transient agro-infiltration studies.
Fauquet et al., New Delhi, India. In Virus Res, Dec 2015
The ACMV genes AC1, AC2, AC4 from DNA-A and BC1 from DNA-B were effective targets for RNAi-mediated resistance and their siRNA expression was higher compared to other RNAi constructs.
The AC5 protein encoded by Mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing-based antiviral defenses.
Zhou et al., Hangzhou, China. In New Phytol, Oct 2015
It is generally accepted that begomoviruses in the family Geminiviridae encode four proteins (from AC1/C1 to AC4/C4) using the complementary-sense DNA as template.
Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats.
Davis et al., United States. In J Appl Physiol, Oct 2015
IPA canonical pathway analysis revealed 18 pathways with significant changes in gene expression when analyzed across vessels and revealed that EX induces increased expression of the following genes in all arterioles examined: Shc1, desert hedgehog protein (Dhh), adenylate cyclase 4 (Adcy4), G protein binding protein, alpha (Gnat1), and Bcl2l1 and decreased expression of ubiquitin D (Ubd) and cAMP response element modulator (Crem).
Development of plants resistant to tomato geminiviruses using artificial trans-acting small interfering RNA.
Mukherjee et al., New Delhi, India. In Mol Plant Pathol, Sep 2015
In geminiviruses, the proteins AC2, AC4 and AV2 are known to act as RNAi suppressors.
Bioorthogonal Labeling, Bioimaging, and Photocytotoxicity Studies of Phosphorescent Ruthenium(II) Polypyridine Dibenzocyclooctyne Complexes.
Lo et al., Hong Kong, Hong Kong. In Chemistry, Aug 2015
Also, the DIBO complexes 1 a and 2 a can selectively label N-azidoglycans located on the surface of CHO-K1 and A549 cells that were pretreated with 1,3,4,6-tetra-O-acetyl-N-azidoacetyl-D-mannosamine (Ac4 ManNAz).
Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression.
Dahle et al., Oslo, Norway. In Hum Immunol, Jun 2015
Rapid down-regulation of the monocyte AC isoforms AC4, AC7 and AC9 were observed in young males.
Effects of salinity and salinity-induced augmented bioactive compounds in purslane (Portulaca oleracea L.) for possible economical use.
Alam et al., Kuala Selangor, Malaysia. In Food Chem, Mar 2015
Purslane accessions Ac4, Ac5, Ac6 and Ac8 possessed potentials for salinity-induced augmented production of bioactive compounds which in turn can be harnessed for possible human health benefits.
Effect of salinity on biomass yield and physiological and stem-root anatomical characteristics of purslane (Portulaca oleracea L.) accessions.
Abdul Hamid et al., Kuala Selangor, Malaysia. In Biomed Res Int, 2014
Considering salinity effect on purslane physiology, increase in chlorophyll content was seen in Ac2, Ac4, Ac6, and Ac8 at 16 dS m(-1) salinity, whereas Ac4, Ac9, and Ac12 showed increased photosynthesis at the same salinity levels compared to control.
Assessment of the genetic diversity of tomato yellow leaf curl virus.
Yang et al., Jiaxing, China. In Genet Mol Res, 2014
The results showed that all TYLCV sequences were 2752-2794 nucleotides in length, which encoded 6 open reading frames (AV1, AV2, AC1, AC2, AC3, and AC4).
Ovarian superstimulation using FSH combined with equine chorionic gonadotropin (eCG) upregulates mRNA-encoding proteins involved with LH receptor intracellular signaling in granulosa cells from Nelore cows.
Barros et al., Botucatu, Brazil. In Theriogenology, 2014
The granulosa cells were harvested from follicles and mRNA abundance of GNAS, GNAQ, GNA11, PLCB1, PLCB, PLCB4, and adenylyl cyclase isoforms (ADCY3, ADCY4, ADCY6, ADCY8, and ADCY9) was measured by real-time reserve transcription followed by polymerase chain reaction.
An integrated transcriptomic and comparative genomic analysis of differential gene expression in Arctic charr (Salvelinus alpinus) following seawater exposure.
Danzmann et al., Guelph, Canada. In J Exp Biol, 2014
Comparative genomics analyses suggest that hypo-osmoregulation is influenced by the relative proximities among a contingent of genes on Arctic charr linkage groups AC-4 and AC-12 that exhibit homologous affinities with a region on stickleback chromosome Ga-I.
Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii.
Ovchinnikova et al., Saint Petersburg, Russia. In Acta Naturae, 2014
The peptides Ac1, Ac2, Ac3, Ac4, and Ac5 were found to be the N-terminal acetylated fragments 1-0, 1-5, 1-9, 1-4, and 1-1 of the histone H2A, respectively, while Ac6 was shown to be the 62-5 fragment of the histone H2A.
Determination of trace levels of parabens in real matrices by bar adsorptive microextraction using selective sorbent phases.
Nogueira et al., Lisbon, Portugal. In J Chromatogr A, 2014
By comparing six polymer (P1, P2, P3, P4, P5 and P6) and five activated carbon (AC1, AC2, AC3, AC4 and AC5) coatings through BAμE, AC2 exhibited much higher selectivity and efficiency from all the sorbent phases tested, even when compared with the commercial stir bar sorptive extraction with polydimethylsiloxane. Assays performed through BAμE(AC2, 1.7mg) on 25mL of ultrapure water samples spiked at the 8.0μg/L level, yielded recoveries ranging from 85.6±6.3% to 100.6±11.8%,
In silico prediction of cotton (Gossypium hirsutum) encoded microRNAs targets in the genome of Cotton leaf curl Allahabad virus.
Khan et al., New Delhi, India. In Bioinformation, 2013
Our results revealed that miRNA species viz., ghr-miR2950 can target all the viral genes, ghr-miR408 targets overlapping transcripts of AC1 and AC2 genes; while ghr-miR394 and ghr-miR395a and miR395d could bind overlapping transcripts of AC1 and AC4 genes.
Screening of purslane (Portulaca oleracea L.) accessions for high salt tolerance.
Aslani et al., Kuala Selangor, Malaysia. In Scientificworldjournal, 2013
Based on dry matter yield reduction, among all 25 purslane accessions 2 accessions were graded as tolerant (Ac7 and Ac9), 6 accessions were moderately tolerant (Ac3, Ac5, Ac6, Ac10, Ac11, and Ac12), 5 accessions were moderately susceptible (Ac1, Ac2, Ac4, Ac8, and Ac13), and the remaining 12 accessions were susceptible to salinity stress and discarded from further study.
Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.
Ostrom et al., Memphis, United States. In J Pharmacol Exp Ther, 2011
AC4 and AC2, both isoforms stimulated by Gbetagamma, are expressed in bronchial nonlipid raft membrane fractions where they colocalize with and couple to prostanoid EP2 receptors.
Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells.
Schimmer et al., Toronto, Canada. In Endocrinology, 2008
SF1 and SP1 contribute to Adcy4 promoter activity via interation with conserved region situated 19 bp upstream of the major transcription start site.
Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.
Schimmer et al., Toronto, Canada. In Mol Cell Endocrinol, 2004
Adcy4 deficiency is a hallmark of the forskolin-resistant phenotype of the adrenocortical tumor mutants studied and Adcy4 is an important target of forskolin action in the Y1 adrenal cell line.
Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.
Levi et al., Roma, Italy. In J Neurochem, 2001
The HIV-1 regulatory protein Tat was shown to inhibit the activity of adenylyl cyclase in rat microglial cells.
Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.
Storm et al., Seattle, United States. In Neuron, 2000
This paper reports the presence of adenylyl cyclases 2, 3, and 4 in mouse olfactory cilia.
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