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Adenylate cyclase 3

AC3, adenylyl cyclase 3, ACIII
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AC4, ACID, V1a
Papers on AC3
CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis.
Grumbach et al., Iowa City, United States. In Am J Physiol Lung Cell Mol Physiol, Feb 2016
We generated a novel transgenic model of inducible expression of the CaMKII inhibitor peptide AC3-I limited to type II pneumocytes (Tg SPC-AC3-I).
bFGF and VEGF improve the quality of vitrified-thawed human ovarian tissues after xenotransplantation to SCID mice.
Li et al., Chengdu, China. In J Assist Reprod Genet, Jan 2016
The effect of transplantation was assessed by histological analysis, immunohistochemical staining for CD34, Ki-67, and AC-3 expression, and microvessel density (MVD).
The complement of family M1 aminopeptidases of Haemonchus contortus - Biotechnological implications.
Gasser et al., Melbourne, Australia. In Biotechnol Adv, Nov 2015
Hc-AP-9 and Hc-AP-10 to C. elegans PAM-1 (isoform b) (53-54% similar); Hc-AP-11 and Hc-AP-12 to C. elegans AC3.5 and Y67D8C.9
Advancing Cancer Control Through Research and Cancer Registry Collaborations in the Caribbean.
Ragin et al., Philadelphia, United States. In Cancer Control, Oct 2015
METHODS: The African-Caribbean Cancer Consortium (AC3) is a broad-based resource for education, training, and research on all aspects of cancer in populations of African descent.
Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice.
Ma et al., Baoding, China. In Int J Mol Sci, 2014
Adenylyl Cyclase 3 (AC3) plays an important role in the olfactory sensation-signaling pathway in mice.
Self-Report Daily Life Activity as a Prognostic Marker of Idiopathic Pulmonary Fibrosis.
Behr et al., M√ľnchen, Germany. In Respiration, 2014
Thirty-two patients were in AC I/II, 98 in AC III and 26 patients in AC IV.
Routes to cAMP: shaping neuronal connectivity with distinct adenylate cyclases.
Gaspar et al., Paris, France. In Eur J Neurosci, 2014
The implication of specific AC isoforms in neural wiring was only recently demonstrated in mouse mutants, knockout (KO) for different AC isoforms, AC1, AC3, AC5, AC8 and soluble (s)AC/AC10.
The 4th Bi-annual international African-Caribbean Cancer Consortium conference: building capacity to address cancer health disparities in populations of African descent.
Ragin et al., Philadelphia, United States. In Infect Agent Cancer, 2013
This is a brief summary of the 4(th) International Meeting of the African-Caribbean Cancer Consortium (AC3), organized and sponsored by Fox Chase Cancer Center (FCCC), and held on July 21-22, 2012 at the Lincoln University Graduate Center, Lincoln Plaza, Philadelphia, Pennsylvania.
Opioid-receptor (OR) signaling cascades in rat cerebral cortex and model cell lines: the role of plasma membrane structure.
Svoboda et al., Praha, Czech Republic. In Physiol Res, 2013
Increase of ACI and ACII represented the specific effect as the amount of ACIII-ACIX, prototypical PM marker Na, K-ATPase and trimeric G-protein alpha and beta subunits was unchanged.
Alternative Complex III from phototrophic bacteria and its electron acceptor auracyanin.
Blankenship et al., Saint Louis, United States. In Biochim Biophys Acta, 2013
Alternative Complex III (ACIII) is a multisubunit integral membrane protein electron transfer complex that is proposed to be an energy-conserving functional replacement for the bacterial cytochrome bc1 or b6f complexes.
Co-opting the unfolded protein response to elicit olfactory receptor feedback.
Lomvardas et al., San Francisco, United States. In Cell, 2013
ATF5 induces the transcription of adenylyl cyclase 3 (Adcy3), which relieves the UPR.
Renal and cardiovascular sensory receptors and blood pressure regulation.
Pluznick, Baltimore, United States. In Am J Physiol Renal Physiol, 2013
This review will focus on several recent studies examining the roles that sensory receptors play in blood pressure regulation, with an emphasis on three pathways: the adenylate cyclase 3 (AC3) pathway, the Gpr91-succinate signaling pathway, and the Olfr78/Gpr41 short-chain fatty acid signaling pathway.
An epigenetic trap stabilizes singular olfactory receptor expression.
Lomvardas et al., San Francisco, United States. In Cell, 2013
Here, we identify the transient expression of histone demethylase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiation and stabilization of OR expression.
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.
Sullivan et al., Brisbane, Australia. In Mol Psychiatry, 2012
This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder.
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Reiter et al., San Francisco, United States. In Nat Genet, 2011
Cell types that do not require Tctn1 for ciliogenesis require it to localize select membrane-associated proteins to the cilium, including Arl13b, AC3, Smoothened and Pkd2.
The type 3 adenylyl cyclase is required for novel object learning and extinction of contextual memory: role of cAMP signaling in primary cilia.
Storm et al., Baoding, China. In J Neurosci, 2011
AC3(-/-) mice show no short-term memory for novel objects and fail to exhibit extinction of contextual fear conditioning
Maternal behavior is impaired in female mice lacking type 3 adenylyl cyclase.
Storm et al., Baoding, China. In Neuropsychopharmacology, 2011
Maternal behavior was impaired in female mice deficient in adenylyl cyclase 3.
Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice.
Turnbull et al., Hamilton, Canada. In Bmc Neurosci, 2010
In primary culture and in situ in G93A SOD1 mice there is a large reduction in the proportion of motor neurons bearing a primary cilium.
Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
Gu et al., Nanjing, China. In Plos One, 2009
Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population.
U1-mediated exon definition interactions between AT-AC and GT-AG introns.
Krainer et al., United States. In Science, 1996
A minor class of metazoan introns has well-conserved splice sites with 5'-AU-AC-3' boundaries, compared to the 5'-GU-AG-3' boundaries and degenerate splice sites of conventional introns.
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