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V-abl Abelson murine leukemia viral oncogene homolog 2

ABL2, Arg tyrosine kinase, ABLL
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: ABL, CAN, HAD, BCR, POLYMERASE
Papers on ABL2
MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2.
New
Xue et al., Changsha, China. In Drug Des Devel Ther, Dec 2015
The direct regulation of miR-125a-5p on its target gene, ABL proto-oncogene 2 (ABL2), in cervical carcinoma was evaluated by quantitative real-time reverse transcription polymerase chain reaction, Western blotting and luciferase reporter assays, respectively.
The Emerging Role of ABL Kinases in Solid Tumors.
New
Pendergast et al., Durham, United States. In Trends Cancer, Nov 2015
Emerging data has shown a role for the ABL family kinases, ABL1 and ABL2, in the progression of several solid tumors.
Structure of the ABL2/ARG kinase in complex with dasatinib.
New
Boggon et al., New Haven, United States. In Acta Crystallogr Sect F Struct Biol Commun, Apr 2015
ABL2/ARG (ABL-related gene) belongs to the ABL (Abelson tyrosine-protein kinase) family of tyrosine kinases.
Copy number variability analysis of pharmacogenes in patients with lymphoma, leukemia, hepatocellular, and lung carcinoma using The Cancer Genome Atlas data.
Oh et al., Seoul, South Korea. In Pharmacogenet Genomics, 2015
P2RY12 and P2RY1 had the highest frequency for gene gain in LUSC (26.95 and 26.68%, respectively) whereas ABCB1 and ABL2 had the highest frequency for gene gain in DLBL (27.27%) in cancer tissue or blood.
Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility.
Pendergast et al., Durham, United States. In Plos One, 2014
Here we show that Abl family of non-receptor tyrosine kinases, comprised of Abl (ABL1) and Arg (ABL2), are activated downstream of the Met receptor, and that inhibition of Abl kinases dramatically suppresses HGF-induced cell scattering and tubulogenesis.
Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.
Sugimura et al., Hamamatsu, Japan. In Sci Rep, 2014
Moreover, ROS1, HCK, ABL1, ABL2, JAK3, LCK and TYR03 were identified as candidate kinases responsible for the phosphorylation of Tyr(136) of LIX1L.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
miR-20a promotes prostate cancer invasion and migration through targeting ABL2.
Shi et al., Tianjin, China. In J Cell Biochem, 2014
Furthermore, we identified miR-20a directly targets the ABL family non-receptor tyrosine kinases ABL2 and negatively regulates the phosphorylation of its downstream gene p190RhoGAP.
Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility.
Klagsbrun et al., Boston, United States. In Biochem Biophys Res Commun, 2014
A key signaling step is that SEMA3A&F activates ABL2 tyrosine kinase, which activates p190RhoGAP, which in turn inactivates RhoA, thereby diminishing stress fiber formation and ensuing cell migration.
[RIN1 expression in hepatocellular cancer and the affection on prognosis and tumor invasion ability].
Liu et al., Shenyang, China. In Zhonghua Wai Ke Za Zhi, 2013
RIN1 expression and ABL2 and E calcium protein were positively correlated (r = 0.898 and 0.912, P < 0.05), and negatively correlated with MMP-9 (r = -0.933,
Role of ABL family kinases in cancer: from leukaemia to solid tumours.
Review
Impact
Pendergast et al., Durham, United States. In Nat Rev Cancer, 2013
The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion.
A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study.
Impact
Oh et al., Boston, United States. In Lancet Oncol, 2012
FINDINGS: A six-gene model (consisting of ABL2, SEMA4D, ITGAL, and C1QA, TIMP1, CDKN1A) separated patients with castration-resistant prostate cancer into two risk groups: a low-risk group with a median survival of more than 34·9 months (median survival was not reached) and a high-risk group with a median survival of 7·8 months (95% CI 1·8-13·9; p<0·0001).
Arg/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin.
GeneRIF
Koleske et al., New Haven, United States. In Biochemistry, 2012
our studies reveal a potentially important mechanism by which ABL2 recruits cortactin to F-actin by increasing its binding stoichiometry with the filament
The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.
GeneRIF
Koleske et al., New Haven, United States. In Mol Cell Biol, 2012
Abl and Arg play complementary, nonredundant roles in the phagocytosis of opsonized beads and Leishmania
c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.
GeneRIF
Plattner et al., Lexington, United States. In Oncogene, 2012
c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo
Knockout mutation of p27-p55 operon severely reduces replication of Mycobacterium bovis in a macrophagic cell line and survival in a mouse model of infection.
GeneRIF
Bigi et al., Buenos Aires, Argentina. In Virulence, 2011
Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice.
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.
GeneRIF
Gil-Henn et al., New Haven, United States. In Cancer Res, 2011
Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion
ABL tyrosine kinases: evolution of function, regulation, and specificity.
Review
Colicelli, Los Angeles, United States. In Sci Signal, 2009
Two vertebrate paralogs, ABL1 and ABL2, have evolved to perform specialized functions.
Chronic myeloproliferative disorders: a tyrosine kinase tale.
Review
Cools et al., Leuven, Belgium. In Leukemia, 2006
Some of the Ph-negative myeloproliferative diseases are characterized by other chromosomal translocations involving a variety of tyrosine kinase genes, including ABL1, ABL2, PDGFRA, PDGFRB, FGFR1, and JAK2.
The BCR-ABL story: bench to bedside and back.
Review
Impact
Witte et al., Los Angeles, United States. In Annu Rev Immunol, 2003
Imatinib mesylate (Gleevec, STI571, or CP57148B) is a direct inhibitor of ABL (ABL1), ARG (ABL2), KIT, and PDGFR tyrosine kinases.
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