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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

C-abl oncogene 1, non-receptor tyrosine kinase

ABL, MTP, c-Abl, bcr/abl
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BCR, CAN, HAD, V1a, Src
Papers using ABL antibodies
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line.
Häcker Georg, In PLoS ONE, 2008
... Anti-SQSTM1, anti-Actin, anti-Hsp90, anti-Hsp60 and anti-Abl antibodies were from Santa Cruz Biotechnology (Tebu-Bio, Le Perray en ...
Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib
Labourier E et al., In Blood Cancer Journal, 2008
... Samples from the First World Health Organization International Genetic Reference Panel for quantitation of BCR–ABL mRNA, comprising four dilution levels of freeze-dried K562 cells diluted in HL-60 cells, were processed using 600 μl of RLT buffer (Qiagen, Valencia, CA, USA) as ...
The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors
Linden Rafael, In PLoS ONE, 2005
... Src, p-Src, FAK, p-FAK and p-c-ABL antibodies were purchased from Cell Signaling.
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1
Billadeau Daniel D. et al., In The Journal of Cell Biology, 2003
... The antibody for Abl (clone 8E9) was purchased from BD Biosciences, and the antibody for ...
A statistical model for identifying proteins by tandem mass spectrometry.
Khan Wasif N., In PLoS ONE, 2002
... For SILAC analysis, v-Abl transformed pre-B cells were grown in light media as per the SILAC protein quantitation kit-RPMI 1640 (Pierce Thermo Scientific cat.# 89982) ...
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Papers on ABL
Discovery of 2-((3-amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a potent, selective and orally available BCR-ABL/SRC/p38 kinase inhibitor for Chronic Myeloid Leukemia.
Liu et al., In J Med Chem, Feb 2016
UNASSIGNED: Starting from a dihydropyrimidopyrimidine core scaffold based compound 27 (GNF-7), we discovered a highly potent (ABL1: IC50 of 70 nM) and selective (S score (1) = 0.02) BCR-ABL inhibitor 18a (CHMFL-ABL-053).
Multifunctional Abl kinases in health and disease.
Pendergast et al., Durham, United States. In J Cell Sci, Feb 2016
The Abl family kinases Abl1 and Abl2 regulate diverse cellular processes during development and normal homeostasis, and their functions are subverted during inflammation, cancer and other pathologies.
MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2.
Xue et al., Changsha, China. In Drug Des Devel Ther, Dec 2015
The direct regulation of miR-125a-5p on its target gene, ABL proto-oncogene 2 (ABL2), in cervical carcinoma was evaluated by quantitative real-time reverse transcription polymerase chain reaction, Western blotting and luciferase reporter assays, respectively.
Immunohistochemical Analysis of PDGFR-α, PDGFR-β and c-Abl in Retinoblastoma: Potential Therapeutic Targets.
Burnier et al., Montréal, Canada. In Ophthalmic Res, Dec 2015
AIMS: The purpose of this project was to determine the immunoexpression of platelet-derived growth factor receptor (PDGFR)-α, PDGFR-β and c-Abl in 61 human samples of Rb to determine if IM-sensitive receptors are present.
Dermatofibrosarcoma protuberans: from translocation to targeted therapy.
Jones et al., London, United Kingdom. In Cancer Biol Med, Dec 2015
In recent years, imatinib, a PDGFβR, ABL and KIT inhibitor, has revolutionized systemic therapy in DFSP.
Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression.
Hadzopoulou-Cladaras et al., Thessaloníki, Greece. In Plos One, Dec 2015
The effect of camphene is most likely regulated through SREBP-1 by affecting MTP levels in response to a decrease in the intracellular cholesterol.
Identification of a Novel Transcript and Regulatory Mechanism for Microsomal Triglyceride Transfer Protein.
Swift et al., Nashville, United States. In Plos One, Dec 2015
Microsomal triglyceride transfer protein (MTP) is essential for the assembly of triglyceride-rich apolipoprotein B-containing lipoproteins.
Novel therapies in small cell lung cancer.
Jalal et al., Indianapolis, United States. In Transl Lung Cancer Res, Oct 2015
Several of them including EGFR TKIs, BCR-ABL TKIs, mTOR inhibitors, and VEGF inhibitors have been unsuccessful in showing a survival advantage in this disease.
Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists.
Leboulch et al., Fontenay-aux-Roses, France. In Nature, Oct 2015
CML is a myeloproliferative disorder that results from dysregulated tyrosine kinase activity of the fusion oncoprotein BCR-ABL.
Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism.
Kern et al., Waltham, United States. In Science, Mar 2015
Here, we recreate the evolutionary pathway between two modern human oncogenes, Src and Abl, by reconstructing their common ancestors.
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
Lane et al., Boston, United States. In Nat Med, 2015
In several human tumors, mutations in the gene encoding GNB1 co-occurred with oncogenic kinase alterations, including the BCR-ABL fusion protein, the V617F substitution in JAK2 and the V600K substitution in BRAF.
Hsp90 Inhibitors for the Treatment of Chronic Myeloid Leukemia.
Baskaran et al., Pondicherry, India. In Leuk Res Treatment, 2014
Chronic myeloid leukemia (CML) is a hematological malignancy that arises due to reciprocal translocation of 3' sequences from c-Abelson (ABL) protooncogene of chromosome 9 with 5' sequence of truncated break point cluster region (BCR) on chromosome 22.
Efficacy of Dasatinib in a CML Patient in Blast Crisis with F317L Mutation: A Case Report and Literature Review.
Afanasyev et al., Saint Petersburg, Russia. In Biomark Insights, 2014
One of the main reasons for treatment failure is a mutation in the BCR-ABL gene, which leads to therapy resistance and clonal evolution.
Tracking cancer drugs in living cells by thermal profiling of the proteome.
Drewes et al., Heidelberg, Germany. In Science, 2014
In live cells, dasatinib induced shifts in BCR-ABL pathway proteins, including CRK/CRKL.
Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease.
Pui et al., In J Clin Oncol, 2014
PURPOSE: BCR-ABL1–like acute lymphoblastic leukemia (ALL) is a recently identified B-cell ALL (B-ALL)subtype with poor outcome that exhibits a gene expression profile similar to BCR-ABL1-positive ALL but lacks the BCR-ABL1 fusion protein.
Mutations in the HFE, TFR2, and SLC40A1 genes in patients with hemochromatosis.
Morán-Jiménez et al., Madrid, Spain. In Gene, 2012
Mutations in the SLC40A1 gene is associated with hemochromatosis.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.
Li et al., Shanghai, China. In Nat Cell Biol, 2012
Identify c-Abl as a regulator of bone morphogenetic protein signalling pathways and uncover a role for c-Abl in p16(INK4a) expression and osteoprogenitor expansion.
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
Chen et al., Beijing, China. In Neoplasia, 2012
Bcr-Abl may critically requires tyrosine phosphorylation of SOCS-1 and SOCS-3 to mediate tumorigenesis when these SOCS proteins are present in cells.
Comprehensive analysis of BCR/ABL variants in chronic myeloid leukemia patients using multiplex RT-PCR.
Sennana et al., Sousse, Tunisia. In Clin Lab, 2011
Multiplex RT-PCR is a fast and reliable technique for improved detection of typical and atypical BCR/ABL transcripts.
More papers using ABL antibodies
Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells.
Van Nhieu Guy Tran, In PLoS Pathogens, 1997
... (R&D), rabbit anti-phospho-PDGFRβ (Tyr751) (Cell Signaling), rabbit anti-EGFR (Santa Cruz), mouse anti-Abl (Santa Cruz), rabbit anti-Abl-pY412 (Cell Signaling Technology), mouse anti-4G10 (Upstate), ...
Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene
Nekhai Sergei et al., In Retrovirology, 1991
... Mouse monoclonal anti-ferroportin (MTP-1) antibody was purchased from Alpha Diagnostics.
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