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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TNFAIP3 interacting protein 2

ABIN-2, Klip
TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the ERK (see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006 [PubMed 16633345]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: A20, NF-kappaB, Cot, Ubiquitin, ERK
Papers on ABIN-2
Nepetaefuran and leonotinin isolated from Leonotis nepetaefolia R. Br. potently inhibit the LPS signaling pathway by suppressing the transactivation of NF-κB.
New
Funakoshi-Tago et al., Tokyo, Japan. In Int Immunopharmacol, Oct 2015
Leonotis nepetaefolia R. Br., also known as Klip Dagga or Lion's Ear, has traditionally been used as a folk medicine to treat inflammatory diseases such as rheumatism, bronchitis, and asthma; however, the components that exhibit its anti-inflammatory activity have not yet been identified.
USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2.
New
Zhang et al., Jinan, China. In Oncotarget, Oct 2015
Furthermore, we revealed that USP35 acts as a functional DUB and stabilizes TNFAIP3 interacting protein 2 (ABIN-2) by promoting its deubiquitination.
Characterization and structure prediction of partial length protein sequences of pcoA, pcoR and chrB genes from heavy metal resistant bacteria from the Klip River, South Africa.
Pillay et al., Vanderbijlpark, South Africa. In Int J Mol Sci, 2014
The Klip River has suffered from severe anthropogenic effects from industrial activities such as mining.
Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
Ley et al., London, United Kingdom. In J Immunol, 2014
Importantly, using a newly generated mouse strain expressing a kinase-inactive form of TPL-2, we demonstrated that stimulation of EAE was dependent on the catalytic activity of TPL-2 and not its adaptor function to stabilize the associated ubiquitin-binding protein ABIN-2.
The biology of A20-binding inhibitors of NF-kappaB activation (ABINs).
Review
Beyaert et al., In Adv Exp Med Biol, 2013
The family of A20-Binding Inhibitors of NF-kappaB (ABINs) consists of three proteins, ABIN-1, ABIN-2 and ABIN-3, which were originally identified as A20-binding proteins and inhibitors of cytokines and Lipopolysaccharide (LPS) induced NF-kappaB activation.
Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells.
Ley et al., London, United Kingdom. In Biochem J, 2013
Co-expression with Ebola virus VP35 (virus protein 35), which blocked plasmid activation of PKR, substantially increased production of recombinant TPL-2 (tumour progression locus 2)-ABIN-2 [A20-binding inhibitor of NF-κB (nuclear factor κB) 2]-NF-κB1 p105 complex.
Diverse norovirus genotypes identified in sewage-polluted river water in South Africa.
Taylor et al., Pretoria, South Africa. In Epidemiol Infect, 2013
Between January 2008 and December 2010, three rivers, namely Klip, Suikerbosrant, and Rietspruit were monitored for NoV genogroup (G)I and GII.
First detection of human sapoviruses in river water in South Africa.
Taylor et al., Pretoria, South Africa. In Water Sci Technol, 2012
Over a 2-year period, from January 2009 to December 2010, water samples were collected from three rivers (Klip, Rietspruit and Suikerbosrand) in the Vaal River System, South Africa.
A20 inactivation in ocular adnexal MALT lymphoma.
Du et al., Cambridge, United Kingdom. In Haematologica, 2012
It is also unknown whether ABIN-1 and ABIN-2, the components of the A20 NF-κB inhibitor complex, are inactivated by genetic changes in ocular adnexal mucosa-associated lymphoid tissue lymphoma.
IκB kinase regulation of the TPL-2/ERK MAPK pathway.
Review
Ley et al., London, United Kingdom. In Immunol Rev, 2012
TPL-2 is stoichiometrically complexed with the NF-κB inhibitory protein, NF-κB1 p105, and the ubiquitin-binding protein ABIN-2, both of which are required to maintain TPL-2 protein stability.
A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.
GeneRIF
Baud et al., Paris, France. In J Biol Chem, 2011
ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha.
A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.
GeneRIF
Du et al., Cambridge, United Kingdom. In Clin Cancer Res, 2011
A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.
Review
Ley et al., London, United Kingdom. In Cell Res, 2011
In unstimulated cells, TPL-2 is stoichiometrically complexed with the NF-κB inhibitory protein NF-κB1 p105, which blocks TPL-2 access to its substrate MEK, and the ubiquitin-binding protein ABIN-2 (A20-binding inhibitor of NF-κB 2), both of which are required to maintain TPL-2 protein stability.
IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
GeneRIF
Cohen et al., Dundee, United Kingdom. In Biochem J, 2009
The IRAK1-, IKKbeta- and PP2-independent dissociation of Tpl2 from ABIN2 is one of the two signalling events involved in activation of the native Tpl2 complex by IL-1.
ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.
Review
GeneRIF
Beyaert et al., Gent, Belgium. In Biochem Pharmacol, 2009
This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains.
ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells.
GeneRIF
Beyaert et al., Brussels, Belgium. In Oncogene, 2008
role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells.
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
Impact
GeneRIF
Ley et al., London, United Kingdom. In Nat Immunol, 2006
ABIN-2 acts to positively regulate the Erk signaling potential by stabilizing TPL-2.
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