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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Abhydrolase domain containing 4

ABH4, Abhd4, abhydrolase domain containing 4, alpha/beta-hydrolase 4
Top mentioned proteins: CAN, Phosphodiesterase, SHIP, PTPN22, CB1
Papers on ABH4
Role of the Li(+) node in the Li-BH4 substructure of double-cation tetrahydroborates.
Černý et al., Genève, Switzerland. In Acta Crystallogr Sect B Struct Sci Cryst Eng Mater, 2014
The phase diagram LiBH4-ABH4 (A = Rb,Cs) has been screened and revealed ten new compounds LiiAj(BH4)i+j (A = Rb, Cs), with i, j ranging between 1 and 3, representing eight new structure types amongst homoleptic borohydrides.
Transcriptome analysis of in vivo and in vitro matured bovine MII oocytes.
Gardner et al., United States. In Theriogenology, 2009
Following normalization of the microarray data, analysis revealed 10 differentially expressed genes after IVM compared to in vivo matured controls, including Aqp3, Sept7, Abhd4 and Siah2 (P<0.05).
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.
Cravatt et al., Los Angeles, United States. In J Biol Chem, 2008
Previously, we proposed an enzymatic route for producing NAEs that involves the double-O-deacylation of N-acyl phosphatidylethanolamines (NAPEs) by alpha/beta-hydrolase 4 (ABDH4 or Abh4) to form glycerophospho (GP)-NAEs, followed by conversion of these intermediates to NAEs by an unidentified phosphodiesterase.
Multiple pathways involved in the biosynthesis of anandamide.
Kunos et al., Bethesda, United States. In Neuropharmacology, 2008
One involves the sequential deacylation of NAPE by alpha,beta-hydrolase 4 (Abhd4) and the subsequent cleavage of glycerophosphate to yield anandamide, and the other one proceeds through phospholipase C-mediated hydrolysis of NAPE to yield phosphoanandamide, which is then dephosphorylated by phosphatases, including the tyrosine phosphatase PTPN22 and the inositol 5' phosphatase SHIP1.
Coevolution between cannabinoid receptors and endocannabinoid ligands.
Kilpatrick et al., United States. In Gene, 2007
We addressed this debate with a coevolutionary analysis, by examining genes for CB1, CB2, and ten genes that encode ligand metabolic enzymes: abhydrolase domain containing 4 protein, cyclooxygenase 2, diacylglycerol lipase paralogs (DAGLalpha, DAGLbeta), fatty acid amide hydrolase paralogs (FAAH1, FAAH2), monoglyceride lipase, N-acylethanolamine acid amidase, NAPE-selective phospholipase D, and protein tyrosine phosphatase non-receptor type 22. Gene trees (cladograms) of CB1, CB2, and ligand enzymes were obtained by searching for orthologs (tBLASTn) in the genomes of nine phylogenetically diverse species, aligning ortholog sequences with ClustalX, and applying Bayesian analysis (MrBayes).
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.
GeneRIF
Cravatt et al., Los Angeles, United States. In J Biol Chem, 2006
Lysophospholipase/phospholipase B (EC 3.1.1.5) specific for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the biosynthesis of N-acyl ethanolamines including the endocannabinoid anandamide.
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
O'Connor et al., Duarte, United States. In J Biol Chem, 2005
Other purified human AlkB homologue proteins ABH4, ABH6, and ABH7 do not manifest activity.
A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats.
Bahrami et al., Vienna, Austria. In Shock, 2002
Most recently we have shown that 4-aminotetrahydrobiopterin (4-ABH4), an analogue of tetrahydrobiopterin (cofactor of NO synthase), even administered 2 h after endotoxin challenge, improves survival rate in rats.
Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue.
Werner et al., Vienna, Austria. In Shock, 2000
We studied the effects of a novel pterin antagonist of NO synthase, the 4-amino analogue of tetrahydrobiopterin (4-ABH4), in a rat model of endotoxic shock and compared its properties with those of N(G)-monomethyl L-arginine (L-NMMA).
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