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ATP-binding cassette, sub-family F

ABCF2, ATP-binding cassette, sub-family F, member 2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RLI, V1a, OUT, AGE, ABCD4
Papers on ABCF2
The role of ATP-binding cassette transporter genes in the progression of prostate cancer.
Ozen et al., Erzurum, Turkey. In Prostate, Jan 2016
In this study, we aimed to profile expressions of nine ABC transporters, ABCA5, ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC5, ABCC10, and ABCF2, in recurrent, non-recurrent PCa and normal prostate tissues.
Early targets of miR-34a in neuroblastoma.
Zollo et al., Napoli, Italy. In Mol Cell Proteomics, 2014
By combining the proteomics data with Kaplan Meier gene-expression studies, we identified seven new gene products (ALG13, TIMM13, TGM2, ABCF2, CTCF, Ki67, and LYAR) that were correlated with worse clinical outcomes.
Profiling of ABC transporters during active ulcerative colitis and in vitro effect of inflammatory modulators.
Paul et al., New Delhi, India. In Dig Dis Sci, 2013
We also analyzed the effect of inflammatory modulators like TNF-α, lipopolysaccharides (LPS) and drugs (5-ASA, prednisolone and hydrocortisone) on the expression of ABCA1, ABCB8, ABCF2 and ABCC4 using HT-29 cells.
Genome-wide identification, characterization and phylogenetic analysis of 50 catfish ATP-binding cassette (ABC) transporter genes.
Liu et al., Auburn, United States. In Plos One, 2012
Gene duplications in catfish were found for ABCA1, ABCB3, ABCB6, ABCC5, ABCD3, ABCE1, ABCF2 and ABCG2.
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Rudan et al., Zagreb, Croatia. In Plos Genet, 2012
Four loci contained genes encoding glycosyltransferases (ST6GAL1, B4GALT1, FUT8, and MGAT3), while the remaining 5 contained genes that have not been previously implicated in protein glycosylation (IKZF1, IL6ST-ANKRD55, ABCF2-SMARCD3, SUV420H1, and SMARCB1-DERL3).
Keratinocyte ATP binding cassette transporter expression is regulated by ultraviolet light.
Schmitz et al., Regensburg, Germany. In J Photochem Photobiol B, 2012
The long but not the short alternative splice variant of the ABCF2 was found to be markedly upregulated rapidly after UVB irradiation.
Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells.
Okada et al., Suzuka, Japan. In J Cell Physiol, 2012
Overexpression of ABCF2 suppressed RVD.
Profiling of ABC transporters ABCB5, ABCF2 and nestin-positive stem cells in nevi, in situ and invasive melanoma.
Mahalingam et al., Springfield, United States. In Mod Pathol, 2012
Distinct ABCB5 forms and ABCF2, members of the ATP-binding cassette (ABC) superfamily of transporters, are normally expressed in various tissues and cells, and enhanced expression of both has been demonstrated in select cancers.
Cell-free DNA level as a prognostic biomarker for epithelial ovarian cancer.
Kim et al., Seoul, South Korea. In Anticancer Res, 2012
MATERIALS AND METHODS: Preoperative sera of 36 patients with ovarian cancer and of 16 with benign tumors were analyzed using commercially available copy number assay kits to measure the cfDNA level of genes including beta-2-microglobulin (B2M), member RAS oncogene family (RAB25), claudin 4 (CLDN4) and ATP-binding cassette subfamily F member 2 (ABCF2).
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
Soucek et al., Praha, Czech Republic. In Mutagenesis, 2012
Transcript levels of ABCC6, ABCC11, ABCF1 and ABCF2 were significantly lower in non-responders to palliative chemotherapy in comparison with responders.
Relationship between ABCF2 expression and response to chemotherapy or prognosis in clear cell adenocarcinoma of the ovary.
Aoki et al., Tokyo, Japan. In Int J Gynecol Cancer, 2010
OBJECTIVES: The purpose of this study was to evaluate the association of ABCF2 (adenosine triphosphate-binding cassette superfamily F2) protein expression with response to chemotherapy and prognosis in patients with clear cell adenocarcinoma (CCC) of the ovary.
Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line.
Götting et al., Bad Oeynhausen, Germany. In Mol Cell Biochem, 2009
Y79 cells demonstrate high gene expression of ABCA7, ABCA12, ABCB7, ABCB10, ABCC1, ABCC4, ABCD3, ABCE1, ABCF1, ABCF2, and ABCF3 (more than twofold compared to pooled RNA from different tissues).
Can ABCF2 protein expression predict the prognosis of uterine cancer?
Aoki et al., Ōsaka, Japan. In Br J Cancer, 2008
Among cervical cancer cases, 149 (55.8%) expressed ABCF2. The overall survival was longer in ABCF2-negative than ABCF2-positive cases
Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells.
Schmitz et al., Regensburg, Germany. In Melanoma Res, 2007
High expression levels were detected in pooled tissue RNA as well as in cells of melanocytic origin for ABCA5, ABCB2, ABCB6, ABCD3, ABCD4, ABCF1, ABCF2 and ABCF3, whereas ABCB5 revealed a melanocyte-specific high transcript level.
Expression of 25 human ABC transporters in the yeast Pichia pastoris and characterization of the purified ABCC3 ATPase activity.
Urbatsch et al., Lubbock, United States. In Biochemistry, 2007
We analyzed the expression of 25 proteins and demonstrate that 11 transporters, including ABCC3, ABCB6, ABCD1, ABCG1, ABCG4, ABCG5, ABCG8, ABCE1, ABCF1, ABCF2, and ABCF3, were expressed at high levels comparable to that of ABCB1 (P-glycoprotein).
Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs.
Mok et al., Ōsaka, Japan. In Hum Pathol, 2007
Data suggest that ABCF2 protein may be a candidate marker for clear cell adenocarcinomas of the ovary and the uterine corpus and may be important for the pathogenesis of these diseases.
Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses.
Mok et al., Boston, United States. In Clin Cancer Res, 2005
ABCF2 may have a role in progression of clear cell ovarian adenocarcinomas
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