gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ATP-binding cassette, sub-family B

ABCB9, TAPL
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: C-1, TAP1, MHC, ACID, POLYMERASE
Papers on ABCB9
Team work at its best – TAPL and its two domains.
Review
New
Abele et al., In Biol Chem, Sep 2015
The transporter associated with antigen processing (TAPL, ABCB9) is a homodimeric ABC transporter, shuttling cytosolic polypeptides into the lumen of lysosomes energized by ATP hydrolysis.
Single liposome analysis of peptide translocation by the ABC transporter TAPL.
New
Abele et al., Groningen, Netherlands. In Proc Natl Acad Sci U S A, Mar 2015
We reconstituted the human lysosomal polypeptide ABC transporter TAPL, expressed in Pichia pastoris, into lipid vesicles (liposomes) and performed explicit transport measurements.
Profiling of differentially expressed genes in sheep T lymphocytes response to an artificial primary Haemonchus contortus infection.
Du et al., Hangzhou, China. In Parasit Vectors, 2014
Functional analysis of significant differentially expressed genes, such as SLC9A3R2, ABCB9, COMMD4, SUGT1, FCER1G, GSK3A, PAK4 and FCER2, revealed a crucial association with cellular homeostasis maintenance and immune response.
The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes.
Hansen et al., Copenhagen, Denmark. In Plos One, 2014
OBJECTIVES: A trans-ethnic meta-analysis of type 2 diabetes genome-wide association studies has identified seven novel susceptibility variants in or near TMEM154, SSR1/RREB1, FAF1, POU5F1/TCF19, LPP, ARL15 and ABCB9/MPHOSPH9.
Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire.
van Hall et al., Leiden, Netherlands. In Mol Immunol, 2014
A novel TEIPP peptide-epitope that represented this intracellular route revealed that the lysosomal peptide transporter ABCB9 ('TAP-like') was dispensable for its presentation.
MicroRNA-31 inhibits cisplatin-induced apoptosis in non-small cell lung cancer cells by regulating the drug transporter ABCB9.
Gong et al., Ningbo, China. In Cancer Lett, 2014
Interestingly, miR-31 was inversely correlated with the expression of the drug resistance gene ABCB9.
Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR.
Abele et al., Frankfurt am Main, Germany. In J Biomol Nmr, 2013
The ATP binding cassette transporter TAPL translocates cytosolic peptides into the lumen of lysosomes driven by the hydrolysis of ATP.
Co-operative function and mutual stabilization of the half ATP-binding cassette transporters HAF-4 and HAF-9 in Caenorhabditis elegans.
Ohashi-Kobayashi et al., Japan. In Biochem J, 2013
Caenorhabditis elegans HAF-4 and HAF-9 are half ABC (ATP-binding-cassette) transporters that are highly homologous to the human lysosomal peptide transporter TAPL [TAP (transporter associated with antigen processing)-like; ABCB9].
The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.
Abele et al., Frankfurt am Main, Germany. In J Cell Sci, 2012
TAPL (ABCB9) is a homodimeric polypeptide translocation machinery which transports cytosolic peptides into the lumen of lysosomes for degradation.
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
Soucek et al., Praha, Czech Republic. In Mutagenesis, 2012
Additionally, transcript levels of ABCB9, ABCB11, ABCG5 and ABCG8 followed the reverse significant trend, i.e. a decrease in direction from colon to rectum.
Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes.
GeneRIF
Maeda et al., Japan. In Biol Pharm Bull, 2010
These results suggest that TAPL may be localized to the microdomains (lipid rafts) of lysosomal membranes enriched in cholesterol.
Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain.
GeneRIF
Abele et al., Frankfurt am Main, Germany. In Traffic, 2010
By dissecting ABCB9, distinct functions were assigned to the core complex and the extra N-terminal transmembrane domain.
Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like.
Maeda et al., Suita, Japan. In Mol Biol Cell, 2009
TAP-like (TAPL; ABCB9) is a half-type ATP-binding cassette (ABC) transporter that localizes in lysosome and putatively conveys peptides from cytosol to lysosome.
Functional dissection of transmembrane domains of human TAP-like (ABCB9).
GeneRIF
Maeda et al., Suita, Japan. In Biochem Biophys Res Commun, 2009
These results suggest that the sorting signal for lysosomes is present within the amino-terminal transmembrane domain (Met(1)-Arg(141)) of the TAPL molecule.
Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL).
GeneRIF
Abele et al., Frankfurt am Main, Germany. In J Biol Chem, 2008
analysis of lipid activation of the lysosomal transport complex ABCB9
Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells.
GeneRIF
Maeda et al., Suita, Japan. In Biol Pharm Bull, 2008
The ATP-binding of TAPL required Mg(2+), and was observed at neutral pH. Chemical cross-linking experiments suggested that TAPL forms a homodimer in the membrane and under the solubilized conditions.
Intracellular peptide transporters in human--compartmentalization of the "peptidome".
Review
Tampé et al., Frankfurt am Main, Germany. In Pflugers Arch, 2007
In the human genome, the five adenosine triphosphate (ATP)-binding cassette (ABC) half transporters ABCB2 (TAP1), ABCB3 (TAP2), ABCB9 (TAP-like), and in part, also ABCB8 and ABCB10 are closely related with regard to their structural and functional properties.
TAP and TAP-like--brothers in arms?
Review
Abele et al., Frankfurt am Main, Germany. In Naunyn Schmiedebergs Arch Pharmacol, 2006
The transporter associated with antigen processing like (TAPL, ABCB9) is a member of the ATP-binding cassette (ABC) transporter family.
share on facebooktweetadd +1mail to friends