Dysfunction of endocytic kinase AAK1 in ALS.
San Francisco, United States. In Int J Mol Sci, 2013
Using the yeast two-hybrid system, we identified the adaptor-associated kinase 1 (AAK1), a regulatory protein in clathrin-coated vesicle endocytic pathway that selectively interacted with the mutant but not the wild-type SOD1.
[Studies on molecular mechanism of toxicity of anticancer drugs].
In Yakugaku Zasshi, 2011
In human cells, overexpression of AAK1 and a human homologue of Akl1, also decreased adriamycin toxicity, suggesting that downregulation of endocytosis via phosphorylaiotn might be involved in the acquisition of adriamycin resistance not only in yeast cells but also in human cells.