PRMT1-mediated arginine methylation controls ATXN2L localization.
Berlin, Germany. In Exp Cell Res, Jun 2015
Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2. Here, we investigated the methylation state of ATXN2L and its significance for ATXN2L localization.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Uppsala, Sweden. In Genome Med, 2014
Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27).
The Number and Complexity of Pure and Recombinant HIV-1 Strains Observed within Incident Infections during the HIV and Malaria Cohort Study Conducted in Kericho, Kenya, from 2003 to 2006.
Silver Spring, United States. In Plos One, 2014
Among the 58 strains from the community cohort, 43.1% were pure subtypes (36.2% A1, 5.2% C, and 1.7% G) and 56.9% were inter-subtype recombinants (29.3% A1D, 8.6% A1CD, 6.9% A1A2D, 5.2% A1C, 3.4% A1A2CD, and 3.4% A2D).
Obesity gene NEGR1 associated with white matter integrity in healthy young adults.
Los Angeles, United States. In Neuroimage, 2014
Here we aim to see whether variants in obesity-associated genes--NEGR1, FTO, MTCH2, MC4R, LRRN6C, MAP2K5, FAIM2, SEC16B, ETV5, BDNF-AS, ATXN2L, ATP2A1, KCTD15, and TNN13K--are associated with white matter microstructural properties, assessed by high angular resolution diffusion imaging (HARDI) in young healthy adults between 20 and 30 years of age from the Queensland Twin Imaging study (QTIM).
Structure and Expression Analyses of SVA Elements in Relation to Functional Genes.
Pusan, South Korea. In Genomics Inform, 2013
In an analysis of genomic structure, SVA elements are detected in the 5' untranslated region (UTR) of HGSNAT (SVA-B), MRGPRX3 (SVA-D), HYAL1 (SVA-F), TCHH (SVA-F), and ATXN2L (SVA-F) genes, while some elements are observed in the 3'UTR of SPICE1 (SVA-B), TDRKH (SVA-C), GOSR1 (SVA-D), BBS5 (SVA-D), NEK5 (SVA-D), ABHD2 (SVA-F), C1QTNF7 (SVA-F), ORC6L (SVA-F), TMEM69 (SVA-F), and CCDC137 (SVA-F) genes.
A synthetic receptor for asymmetric dimethyl arginine.
Chapel Hill, United States. In J Am Chem Soc, 2013
Dynamic combinatorial chemistry was utilized to identify a novel small molecule receptor, A2D, for asymmetric dimethyl arginine (aRMe2), which is a post-translational modification (PTM) in proteins.
Effects of specular component on color differences of different filler type resin composites after aging.
Nagasaki, Japan. In J Dent, 2009
METHODS: Resin composites and shades used in this study were submicron-filled Estelite Sigma (Sigma: Inc, A2, A3, B3, C2, OA2, OA3) and nanofilled Filtek Supreme XT (XT: Clear, A2E, A2B, A3B, C2B, A2D, A3D).
Color characteristics of resin composites in different color modes and geometries.
Nagasaki, Japan. In J Oral Sci, 2009
Resin composites and shades used in this study were submicron filled Estelite Sigma (Sigma: Inc, A2, A3, B3, C2, OA2, OA3) and nanofilled Filtek(TM) Supreme XT (XT: Clear, A2E, A2B, A3B, C2B, A2D, A3D).
[Gabapentin: its mechanisms of action in the year 2003].
Santander, Spain. In Rev Neurol, 2003
DEVELOPMENT: In addition to an unquestionable Gabaergic effect, gabapentin is the first antiepileptic that has been shown to have an effect on the a2d subunit of the voltage dependent calcium channels and on hyperpolarization activated cationic (Ih) currents.