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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ataxin 2-like

A2D, ATXN2L, Ataxin-2 Domain protein
This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, A2B, AGE, V1a, SCA2
Papers on A2D
Late stage modification of receptors identified from dynamic combinatorial libraries.
New
Waters et al., Chapel Hill, United States. In Org Biomol Chem, Dec 2015
To enable these receptors to have broad application as Kme3 sensors, we have developed a method for their late-stage modification, which we used to synthesize biotinylated derivatives of A2B, A2D, and A2G in a single step.
PRMT1-mediated arginine methylation controls ATXN2L localization.
New
Krobitsch et al., Berlin, Germany. In Exp Cell Res, Jun 2015
Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2. Here, we investigated the methylation state of ATXN2L and its significance for ATXN2L localization.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Schiöth et al., Uppsala, Sweden. In Genome Med, 2014
Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27).
The Number and Complexity of Pure and Recombinant HIV-1 Strains Observed within Incident Infections during the HIV and Malaria Cohort Study Conducted in Kericho, Kenya, from 2003 to 2006.
Tovanabutra et al., Silver Spring, United States. In Plos One, 2014
Among the 58 strains from the community cohort, 43.1% were pure subtypes (36.2% A1, 5.2% C, and 1.7% G) and 56.9% were inter-subtype recombinants (29.3% A1D, 8.6% A1CD, 6.9% A1A2D, 5.2% A1C, 3.4% A1A2CD, and 3.4% A2D).
Obesity gene NEGR1 associated with white matter integrity in healthy young adults.
Thompson et al., Los Angeles, United States. In Neuroimage, 2014
Here we aim to see whether variants in obesity-associated genes--NEGR1, FTO, MTCH2, MC4R, LRRN6C, MAP2K5, FAIM2, SEC16B, ETV5, BDNF-AS, ATXN2L, ATP2A1, KCTD15, and TNN13K--are associated with white matter microstructural properties, assessed by high angular resolution diffusion imaging (HARDI) in young healthy adults between 20 and 30 years of age from the Queensland Twin Imaging study (QTIM).
Structure and Expression Analyses of SVA Elements in Relation to Functional Genes.
Kim et al., Pusan, South Korea. In Genomics Inform, 2013
In an analysis of genomic structure, SVA elements are detected in the 5' untranslated region (UTR) of HGSNAT (SVA-B), MRGPRX3 (SVA-D), HYAL1 (SVA-F), TCHH (SVA-F), and ATXN2L (SVA-F) genes, while some elements are observed in the 3'UTR of SPICE1 (SVA-B), TDRKH (SVA-C), GOSR1 (SVA-D), BBS5 (SVA-D), NEK5 (SVA-D), ABHD2 (SVA-F), C1QTNF7 (SVA-F), ORC6L (SVA-F), TMEM69 (SVA-F), and CCDC137 (SVA-F) genes.
A synthetic receptor for asymmetric dimethyl arginine.
Waters et al., Chapel Hill, United States. In J Am Chem Soc, 2013
Dynamic combinatorial chemistry was utilized to identify a novel small molecule receptor, A2D, for asymmetric dimethyl arginine (aRMe2), which is a post-translational modification (PTM) in proteins.
Influence of different shades and LED irradiance on the degree of conversion of composite resins.
Marchi et al., Piracicaba, Brazil. In Braz Oral Res, 2012
Specimens (5 mm ' 2 mm) were prepared with a nanofilled (Filtek Supreme - A2E, A2D, and WE) or microhybrid resin (Opallis - A2E, A2D, and EBleach Low) and were randomly divided into 12 groups (n = 5 each) according to the composite resin and light-curing unit (Elipar FreeLight 2, 1250 mW/cm²; Ultralume 5, 850 mW/cm²).
A2delta ligands gabapentin and pregabalin: future implications in daily clinical practice.
Kouvelas et al., Thessaloníki, Greece. In Hippokratia, 2010
Gabapentin (GP) and pregabalin (PB) are structurally related compounds and their predominant mechanism of action is the inhibition of calcium currents via high-voltage-activated channels containing the a2d-1 subunit.
Comparative translucency of esthetic composite resin restorative materials.
McComb et al., Toronto, Canada. In J Can Dent Assoc, 2009
RESULTS: A continuum of values for the translucency parameter was obtained, ranging from the most opaque (Filtek Supreme Plus A2D) to the most translucent (Ceram X Duo E2).
Effects of specular component on color differences of different filler type resin composites after aging.
Powers et al., Nagasaki, Japan. In J Dent, 2009
METHODS: Resin composites and shades used in this study were submicron-filled Estelite Sigma (Sigma: Inc, A2, A3, B3, C2, OA2, OA3) and nanofilled Filtek Supreme XT (XT: Clear, A2E, A2B, A3B, C2B, A2D, A3D).
Color characteristics of resin composites in different color modes and geometries.
García-Godoy et al., Nagasaki, Japan. In J Oral Sci, 2009
Resin composites and shades used in this study were submicron filled Estelite Sigma (Sigma: Inc, A2, A3, B3, C2, OA2, OA3) and nanofilled Filtek(TM) Supreme XT (XT: Clear, A2E, A2B, A3B, C2B, A2D, A3D).
Comparison of myocardial tissue velocities measured by two-dimensional speckle tracking and tissue Doppler imaging.
Leung et al., Sydney, Australia. In Am J Cardiol, 2008
There are no reference values for 2-dimensional (2D) speckle tracking myocardial velocities (S2D, E2D, A2D), and it is unknown if they are comparable with color tissue Doppler imaging (TDI).
Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
GeneRIF
Krobitsch et al., Berlin, Germany. In Mol Biol Cell, 2007
cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6
[Mechanism of action of antiepileptic drugs and new antiepileptic drugs].
Review
Sánchez et al., Santander, Spain. In Rev Neurol, 2006
Recent reports describing a specific attachment of some antiepileptic drugs to the a2d subunits of the calcium channel and to the synaptic vesicles proteins SV2A open up new perspectives.
[Gabapentin: its mechanisms of action in the year 2003].
Review
Herranz, Santander, Spain. In Rev Neurol, 2003
DEVELOPMENT: In addition to an unquestionable Gabaergic effect, gabapentin is the first antiepileptic that has been shown to have an effect on the a2d subunit of the voltage dependent calcium channels and on hyperpolarization activated cationic (Ih) currents.
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