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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Spectrin, alpha, non-erythrocytic 1

A2A
a filamentous protein that plays an important role in membrane organization [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, A2B, HAD, ACID
Papers on A2A
Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.
Review
New
Ferré, Baltimore, United States. In Psychopharmacology (berl), Feb 2016
OBJECTIVES: A model that considers the striatal adenosine A2A-dopamine D2 receptor heteromer as a key modulator of dopamine-dependent striatal functions (reward-oriented behavior and learning of stimulus-reward and reward-response associations) is introduced, which should explain most of the psychomotor and reinforcing effects of caffeine.
NOX2 Activation of NKT Cells is Blocked by Adenosine A2A Receptor to Inhibit Lung Reperfusion Injury.
New
Laubach et al., Charlottesville, United States. In Am J Respir Crit Care Med, Feb 2016
Adenosine A2A receptor (A2AR) agonists are known to potently attenuate lung ischemia-reperfusion injury and IL-17 production.
Mesenchymal Stem Cells Ageing: Targeting the "Purinome" to Promote Osteogenic Differentiation and Bone Repair.
Review
New
Correia-de-Sá et al., Porto, Portugal. In J Cell Physiol, Feb 2016
Nucleotides and their derivatives act via adenosine P1 (A1 , A2A , A2B and A3 ) and nucleotide-sensitive P2 purinoceptors comprising ionotropic P2X and G-protein-coupled P2Y receptors.
Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists.
New
Lourens et al., Potchefstroom, South Africa. In Bioorg Med Chem Lett, Feb 2016
UNASSIGNED: A novel series of carbamate substituted 2-amino-4,6-diphenylpyrimidines was evaluated as potential dual adenosine A1 and A2A receptor antagonists.
Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGlu5, adenosine A2A and cannabinoid CB1 receptors.
New
Papatheodoropoulos et al., Pátrai, Greece. In Neuroscience, Feb 2016
Furthermore, the synergistic actions in DH were occluded by blockade of adenosine A2A receptors (A2ARs) by their antagonist ZM241385 demonstrating a tonic action of these receptors in DH.
mGlu5, Dopamine D2 and Adenosine A2A Receptors in L-DOPA-Induced Dyskinesias.
Review
New
Di Paolo et al., Québec, Canada. In Curr Neuropharmacol, Jan 2016
In the basal ganglia, mGlu5 receptor negative allosteric modulators also normalize the L-DOPA-induced changes of dopamine D2 receptors, their associated signalling proteins (ERK1/2 and Akt/GSK3) and neuropeptides (preproenkephalin, preprodynorphin) as well as the adenosine A2A receptors expression.
Discovery of aminoquinazoline derivatives as human A2A adenosine receptor antagonists.
New
Hodgson et al., Rahway, United States. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: Novel bicyclic adenosine A2A antagonists with an aminoquinazoline moiety were designed and synthesized.
Astrocyte-derived adenosine is central to the hypnogenic effect of glucose.
New
Rancillac et al., Paris, France. In Sci Rep, Dec 2015
Finally, patch-clamp recordings uncovered the depolarizing effect of adenosine and its A2A receptor agonist, CGS-21680, on sleep-promoting VLPO neurons.
Purinergic signalling in brain ischemia.
Review
New
Pugliese et al., Florence, Italy. In Neuropharmacology, Dec 2015
Evidence up to now in literature indicate that A2A receptor antagonists provide protection centrally by reducing excitotoxicity, while agonists at A2A (and possibly also A2B) and A3 receptors provide protection by controlling massive infiltration and neuroinflammation in the hours and days after brain ischemia.
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.
Impact
Pfeifer et al., Bonn, Germany. In Nature, 2015
The adenosine A2A receptor is the most abundant adenosine receptor in human and murine BAT.
Hetero-oligomerization and Functional Interaction between Purinergic Receptors Expressed in Platelets to Regulate Platelet Shape Change.
Review
Suzuki, In Yakugaku Zasshi, 2014
Adenosine A2A receptor (A2AR), P2Y1 receptor (P2Y1R) and P2Y12 receptor (P2Y12R) are predominantly expressed on human platelets.
Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial.
Impact
Bandak et al., Tampa, United States. In Lancet Neurol, 2014
Tozadenant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor function in animal models of Parkinson's disease.
Adenosine receptors as drug targets--what are the challenges?
Review
Impact
Fredholm et al., Boston, United States. In Nat Rev Drug Discov, 2013
However, only one adenosine receptor-specific agent--the adenosine A2A receptor agonist regadenoson (Lexiscan; Astellas Pharma)--has so far gained approval from the US Food and Drug Administration (FDA).
Concurrent activation of striatal direct and indirect pathways during action initiation.
Impact
Costa et al., Bethesda, United States. In Nature, 2013
Here we develop a novel in vivo method to specifically measure direct- and indirect-pathway SPN activity, using Cre-dependent viral expression of the genetically encoded calcium indicator (GECI) GCaMP3 in the dorsal striatum of D1-Cre (direct-pathway-specific) and A2A-Cre (indirect-pathway-specific) mice.
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.
Impact
Tate et al., Cambridge, United Kingdom. In Nature, 2011
Adenosine receptors and β-adrenoceptors are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins on binding the agonists adenosine or noradrenaline, respectively.
Binding of alphaII spectrin to 14-3-3beta is involved in NCAM-dependent neurite outgrowth.
GeneRIF
Tilling et al., Hamburg, Germany. In Mol Cell Neurosci, 2010
Results indicate that the phosphorylation-dependent interaction between 14-3-3beta and alphaII spectrin acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM.
Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat.
GeneRIF
Ursitti et al., Baltimore, United States. In J Mol Cell Cardiol, 2010
the embryonic mammalian heart expresses a significant amount of alpha II-spectrin with a reduced avidity for beta-spectrin and the ability to promote myocyte growth
Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke.
GeneRIF
Dheen et al., Singapore, Singapore. In Neurochem Int, 2009
Upregulation of Dpysl2 and Spna2 expression in hypertrophic cells in the penumbra regions of cortex and striatum of stroke brain indicates an early neuronal defense mechanism involving active neuronal repair, regeneration and development.
Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation.
GeneRIF
Stevens et al., Mobile, United States. In J Cell Sci, 2008
PDE4D4 interacts with alpha II spectrin within this membrane domain.
Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
GeneRIF
Wang et al., Baltimore, United States. In J Mol Cell Cardiol, 2007
support a critical role for the alphaII-spectrin-SH3i isoform of spectrin in intracellular targeting of connexin 43 to gap junctions
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