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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor necrosis factor, alpha-induced protein 3

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NF-kappaB, Ubiquitin, HAD, CAN, STAT4
Papers using A20 antibodies
Evaluation of a Photographic Chondropathy Score (PCS) for pathological samples in a study of inflammation in tibiofemoral osteoarthritis
Walsh D.A. et al., In Osteoarthritis and Cartilage, 2008
... Polyclonal anti-VEGF (A20) was from Insight Biotechnology, London, UK ...
Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype
Clarkson B et al., In Blood Cancer Journal, 2008
... Mouse leukocytes were identified by staining with PE-CD45.1 (clone A20; Biolegend) and PE-IgG1 isotype control ...
Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer
Berwin Brent et al., In Frontiers in Immunology, 2006
CD4 (L3T4), MHC-II (M5/114.15.2), and CD45.1 (A20) antibodies from eBioscience (San Diego, CA, USA); ...
Papers on A20
Relevance of MicroRNA-18a and MicroRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation.
Maehara et al., Fukuoka, Japan. In Liver Transpl, Feb 2016
In HCC cells, miR-18a regulated the expression of tumor necrosis factor alpha induced protein 3 (TNFAIP3), and miR-199a-5p regulated the expression of hypoxia-inducible factor 1 alpha (HIF1A), vascular endothelial growth factor A (VEGFA), insulin-like growth factor 1 receptor (IGF1R), and insulin-like growth factor 2 (IGF2).
EBV-Positive and EBV-Negative Posttransplant Diffuse Large B Cell Lymphomas Have Distinct Genomic and Transcriptomic Features.
Wlodarska et al., Leuven, Belgium. In Am J Transplant, Feb 2016
EBV(-) PT-DLBCL, however, displayed at least 10 aberrations recurrent in IC-DLBCL, among which characteristic gain of 3/3q and 18q, and loss of 6q23/TNFAIP3 as well as 9p21/CDKN2A.
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
Maverakis et al., Sacramento, United States. In Clin Rev Allergy Immunol, Feb 2016
In addition, there are numerous other genetic susceptibility loci (LCE3, CARD14, NOS2, NFKBIA, PSMA6, ERAP1, TRAF3IP2, IL12RB2, IL23R, IL12B, TNIP1, TNFAIP3, TYK2) and geoepidemiologic factors that contribute to the wide variability seen in psoriasis.
TNF alpha signalling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors.
Beuschlein et al., München, Germany. In Mol Cell Endocrinol, Feb 2016
We identified TNFAIP3/A20, a key molecule of an inhibitory feedback-loop downstream of TNF-receptor 1, CD40, Toll-like receptors, NOD-like receptors and the interleukin-1 receptor signalling cascades, as overexpressed in the adrenocortical carcinoma tumor model.
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.
Aksentijevich et al., Bethesda, United States. In Nat Genet, Jan 2016
Herein we describe a new disease caused by high-penetrance heterozygous germline mutations in TNFAIP3, which encodes the NF-κB regulatory protein A20, in six unrelated families with early-onset systemic inflammation.
Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases.
Buckner et al., Seattle, United States. In Immunol Rev, Jan 2016
Here, we highlight three pathways that participate in inhibition of TLR responses in macrophages and DC, and their implications in autoimmunity; A20, encoded by the TNFAIP3 gene, Lyp encoded by the PTPN22 gene, and the BCAP/PI3K pathway.
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Dixit et al., San Francisco, United States. In Nature, Jan 2016
Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated with critical inflammatory diseases including multiple sclerosis, rheumatoid arthritis and Crohn's disease.
The immunogenetics of Behçet's disease: A comprehensive review.
Remmers et al., Bethesda, United States. In J Autoimmun, Nov 2015
Genome-wide association studies have identified associations with genome-wide significance (P < 5 × 10(-8)) in the IL23R-IL12RB2, IL10, STAT4, CCR1-CCR3, KLRC4, ERAP1, TNFAIP3, and FUT2 loci.
Immunogenetics of juvenile idiopathic arthritis: A comprehensive review.
Prahalad et al., Salt Lake City, United States. In J Autoimmun, Nov 2015
RF-positive polyarticular JIA is associated with many of the shared epitope encoding HLA DRB1 alleles, as well as PTPN22, STAT4 and TNFAIP3 variants.
The immunogenetics of Psoriasis: A comprehensive review.
Bowcock et al., New York City, United States. In J Autoimmun, Nov 2015
These genes span an array of functions that involve antigen presentation (HLA-Cw6, ERAP1, ERAP2, MICA), the IL-23 axis (IL12Bp40, IL23Ap19, IL23R, JAK2, TYK2), T-cell development and T-cells polarization (RUNX1, RUNX3, STAT3, TAGAP, IL4, IL13), innate immunity (CARD14, c-REL, TRAF3IP2, DDX58, IFIH1), and negative regulators of immune responses (TNIP1, TNFAIP3, NFKBIA, ZC3H12C, IL36RN, SOCS1).
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
Wendel et al., New York City, United States. In Nat Med, Oct 2015
Notably, other KMT2D target genes include frequently mutated tumor suppressor genes such as TNFAIP3, SOCS3 and TNFRSF14.
Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.
Jo et al., Taejŏn, South Korea. In Immunity, Aug 2015
Here, we demonstrate that ERRα negatively regulates Toll-like receptor (TLR)-induced inflammation by promoting Tnfaip3 transcription and fine-tuning of metabolic reprogramming in macrophages.
A20 overexpression alleviates pristine-induced lupus nephritis by inhibiting the NF-κB and NLRP3 inflammasome activation in macrophages of mice.
Hao et al., Chongqing, China. In Int J Clin Exp Med, 2014
A20, tumor necrosis factor alpha induced protein 3 (TNFAIP3), is a key negative regulator of inflammation, however whether A20 can regulate lupus nephritis has not been clarified.
Genetics of psoriatic arthritis.
Rahman et al., St. John's, Canada. In Best Pract Res Clin Rheumatol, 2014
Prominent genes identified via GWAS include HLA-Cw6, IL12B, IL23R, IL23A, TNIP1, TNFAIP3, LCE3B-LCE3C, TRAF3IP2, NFkBIA, FBXL19, TYK2, IFIH1, REL, and ERAP1.
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
Lamkanfi et al., Gent, Belgium. In Nature, 2014
Myeloid-cell-specific deletion of the rheumatoid arthritis susceptibility gene A20/Tnfaip3 in mice (A20(myel-KO) mice) triggers a spontaneous erosive polyarthritis that resembles rheumatoid arthritis in patients.
Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.
van der Helm-van Mil et al., In Ann Rheum Dis, 2012
the present data do not support the initial findings that single-nucleotide polymorphisms of TRAF1-C5 and TNFAIP3-OLIG3 rare associated with the severity of joint destruction in RA.
Expression of the autoimmunity associated TNFAIP3 is increased in rheumatoid arthritis but does not differ according to genotype at 6q23.
Wilson et al., In Rheumatology (oxford), 2012
Expression of the autoimmunity associated TNFAIP3 is increased in rheumatoid arthritis but does not differ according to genotype at 6q23.
Expression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis.
Boone et al., Chicago, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
TNFAIP3 expression in intestinal epithelial cell prevented colitis involving dextran sodium sulfate-induced intestinal epithelial cell death, but not colitis driven by T cell-mediated inflammation from trinitrobenzene sulfonate.
Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response.
Das et al., Calcutta, India. In J Immunol, 2012
Leishmania donovani infection drastically reduces ubiquitination of TRAF6, and the deubiquitinating enzyme A20 is significantly upregulated in infected macrophages.
Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.
Betarbet et al., Atlanta, United States. In Neurosci Lett, 2012
The essential components of the A20 ubiquitin-editing complex are present and mainly expressed in neurons. The A20 complex components are also differentially expressed throughout the human brain.
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