Treatment of Langerhans cell histiocytosis: role of BRAF/MAPK inhibition.
Toronto, Canada. In Hematology Am Soc Hematol Educ Program, Jan 2016
The recent discovery of somatic mutations in ARAF and in MAP2K1, which lead to activation of the RAS-RAF-MEK -ERK pathway in the setting of wild-type BRAF, as well as the finding that activating mutation in MAP2K1 are relatively insensitive to MEK inhibitors, suggest that a more detailed understanding of this pathway in LCH may be necessary for the development of more effective targeted therapies.
Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.
Kettering, United Kingdom. In Cancer Discov, Dec 2015
Through combined whole exome and transcriptome sequencing, we identified recurrent kinase fusions involving BRAF, ALK, and NTRK1, as well as recurrent, activating MAP2K1 and ARAF mutations in BRAFV600E-wildtype, non-LCH patients.
A-Raf: A new star of the family of raf kinases.
Glasgow, United Kingdom. In Crit Rev Biochem Mol Biol, Nov 2015
The Raf family kinases (A-Raf, B-Raf and C-Raf) have been intensively studied since being identified in the early 1980s as retroviral oncogenes, especially with respect to the discovery of activating mutations of B-Raf in a large number of tumors which led to intensified efforts to develop drugs targeting Raf kinases.
Phase I/II RAF kinase inhibitors in cancer therapy.
London, United Kingdom. In Expert Opin Investig Drugs, 2013
BRAF is the only RAF family member that is commonly mutated, whilst CRAF and ARAF play important roles in the signal transduction from mutant RAS.
[Regulation of cell survival by RAF kinases].
Amiens, France. In Med Sci (paris), 2010
The RAF proteins (A-RAF, B-RAF et C-RAF) are a family of kinases that play a key role in the regulation of various aspects of cell physiology, among which cell proliferation, differentiation and survival.
Endothelial apoptosis in Braf-deficient mice.
Bethesda, United States. In Nat Genet, 1997
However, genetic studies of C. elegans and Drosophila, as well as the targeted mutagenesis of the murine Araf gene, have failed to support such a role.