Combinatorial genetic analysis of a network of actin disassembly-promoting factors.
Waltham, United States. In Cytoskeleton (hoboken), Jul 2015
Saccharomyces cerevisiae is an ideal system to tackle this problem, both because of its amenabilities to genetic manipulation and live-cell imaging and because only a single gene encodes each of the core disassembly factors: cofilin (COF1), Srv2/CAP (SRV2), Aip1 (AIP1), GMF (GMF1/AIM7), coronin (CRN1), and twinfilin (TWF1).
Elements of functional genital asymmetry in the cow.
Gijón, Spain. In Reprod Fertil Dev, 2013
Among 60 uterine proteins identified by difference gel electrophoresis, relative abundance of nine (acyl-CoA dehydrogenase, very long chain; twinfilin, actin-binding protein, homologue 1; enolase 1; pyruvate kinase isozymes M1/M2 (rabbit); complement factor B Bb fragment ; albumin; fibrinogen gamma-B chain; and ezrin differed (P<0.05) between horns.
Twinfilin-2a is dispensable for mouse development.
Helsinki, Finland. In Plos One, 2010
Mammals express three twinfilin isoforms, of which twinfilin-1 and twinfilin-2a display largely overlapping expression patterns in non-muscle tissues of developing and adult mice.
Regulation of cytoskeletal dynamics by actin-monomer-binding proteins.
Helsinki, Finland. In Trends Cell Biol, 2004
In this article, we focus on recent advances in understanding how the six evolutionarily conserved actin-monomer-binding proteins - profilin, ADF/cofilin, twinfilin, Srv2/CAP, WASP/WAVE and verprolin/WIP - interact with actin monomers and regulate their incorporation into filament ends.