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ABO blood group

A transferase, B transferase, GTB, ABO glycosyltransferase
This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: ACID, glycosyltransferase, CAN, HAD, STEP
Papers on A transferase
Dysregulated LIF and its receptor regulated STAT3 pathway: a possible cause for repeated implantation failure in women with dormant genital tuberculosis?
New
Chaudhury et al., Kharagpur, India. In Fertil Steril, Feb 2016
MAIN OUTCOME MEASURE(S): Measurement of various endometrial receptivity markers including αvβ3 integrin, E-cadherin, MECA-79, mucin-1, and pinopodes and LIF/LIFR-STAT3 signaling molecules expressed in the endometrium of women with dormant genital tuberculosis (GTB) during implantation window and measured also in HSP65-treated hESC.
Staphylococcus aureus genotype B and other genotypes isolated from cow milk in European countries.
New
Graber et al., Bern, Switzerland. In J Dairy Sci, Jan 2016
aureus genotype B (GTB) and GTC being the most prominent genotypes.
Structural insights into a key carotenogenesis related enzyme phytoene synthase of P. falciparum: a novel drug target for malaria.
New
Singh et al., New Delhi, India. In Syst Synth Biol, Dec 2015
Phytoene synthase (PSY), a transferase enzyme that catalyzes the first specific step in carotenoid biosynthesis plays a central role in the regulation of a number of essential functions mediated via carotenoids.
High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner.
New
Evans et al., Edmonton, Canada. In J Biol Chem, Dec 2015
Homologous glycosyltransferases α-(1→3)-N-acetylgalactosaminyltransferase (GTA) and α-(1→3)-galactosyltransferase (GTB) catalyze the final step in ABO(H) blood group A and B antigen synthesis through sugar transfer from activated donor to the H antigen acceptor.
New isoforms and assembly of glutamine synthetase in the leaf of wheat (Triticum aestivum L.).
New
Theg et al., Zhengzhou, China. In J Exp Bot, Nov 2015
Here, three developmentally regulated isoforms of GS holoenzyme in the leaf of wheat (Triticum aestivum L.) seedlings are described using native-PAGE with a transferase activity assay.
Effects of Nanoparticle Size on Multilayer Formation and Kinetics of Tethered Enzymes.
New
Travis et al., Ithaca, United States. In Bioconjug Chem, Oct 2015
Here, we standardize NP attachment strategy (oriented immobilization via hexahistidine tags) and composition (Ni-NTA coated gold NPs), to test the impact of NP size (⌀5, 10, 20, and 50 nm) on multilayer formation, activity, and kinetic parameters (kcat, KM, kcat/KM) of enzymes representing three different classes: glucose-6-phosphate isomerase (GPI), an isomerase; Glyceraldehyde-3-phosphate dehydrogenase S (GAPDHS), an oxidoreductase; and pyruvate kinase (PK), a transferase.
Intrinsic Levanase Activity of Bacillus subtilis 168 Levansucrase (SacB).
López Munguía et al., Ecatepec, Mexico. In Plos One, 2014
As levanase, levansucrase may use levan as substrate and, through a fructosyl-enzyme complex, behave as a hydrolytic enzyme or as a transferase, as demonstrated when glucose and fructose are added as acceptors.
Monolignol ferulate transferase introduces chemically labile linkages into the lignin backbone.
Impact
Ralph et al., East Lansing, United States. In Science, 2014
Herein, we describe the isolation of a transferase gene capable of forming these conjugates and its xylem-specific introduction into poplar.
Complementary innate (anti-A-specific) IgM emerging from ontogenic O-GalNAc-transferase depletion: (Innate IgM complementarity residing in ancestral antigen completeness).
Review
Arend, Iowa City, United States. In Immunobiology, 2014
The structure either passes "completely" through the germline, in transferase-secreting mature tissues becoming the "complete" phenotype AB, or disappears in exhaustive glycotransferase depletion from the differentiating cell surfaces and leaves behind the "incomplete" blood group O-phenotype, which has released a transferase- and O-glycan-depleted, complementary glycoprotein (IgM) into the circulation.
Polysaccharide-synthesizing glycosyltransferases and carbohydrate binding modules: the case of starch synthase III.
Review
Busi et al., Rosario, Argentina. In Protein Pept Lett, 2013
They are founded in all the three domains of life and display three different folds (named GT-A, GTB and GT-C) which are a variant of a common α/β scaffold.
Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis.
GeneRIF
Ye et al., Innsbruck, Austria. In Circ Cardiovasc Genet, 2011
Genetic variations at the ABO locus are associated with circulating levels of ICAM1, P-selectin, and E-selectin.
[C742T mutation of α1, 3 N-acetyl-D-galactosaminyltransferase gene is responsible for A2 subgroup].
GeneRIF
Yan et al., Hangzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
The C742T mutation of the alpha1, 3 N-acetyl-D-galactosaminyl-transferase gene can lead to A2 phenotype and with anti-A1 antibody in serum.
ABO blood group alleles and the risk of pancreatic cancer in a Japanese population.
GeneRIF
Tanaka et al., Nagoya, Japan. In Cancer Sci, 2011
case-control study showed a statistically significant association between ABO blood group and pancreatic cancer risk in a Japanese population
Mutation of ABO gene in Thai blood donors with A3 phenotype.
GeneRIF
Chinswangwatanakul et al., Bangkok, Thailand. In J Med Assoc Thai, 2011
mutation in A3 were charactered in exon 7 of the ABO gene in 10 A3 phenotype Thai blood donors
Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination.
Impact
Duménil et al., Palaiseau, France. In Science, 2011
We found that proliferation of N. meningitidis in contact with host cells increased the transcription of a bacterial gene encoding a transferase that adds phosphoglycerol onto type IV pili.
Pancreatic cancer susceptibility loci and their role in survival.
GeneRIF
Canzian et al., Heidelberg, Germany. In Plos One, 2010
Data show that single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk.
Renin secretion and total body sodium: pathways of integrative control.
Review
Damkjaer et al., Odense, Denmark. In Clin Exp Pharmacol Physiol, 2010
3. Renal functions involved in sodium homeostasis include: (i) the rate of glomerular filtration (GFR) determined by renal haemodynamics, including tubuloglomerular feedback (TGF); (ii) proximal tubular reabsorption involving glomerulotubular balance (GTB) and neurohumoral control; (iii) macula densa mechanisms influencing TGF and renin secretion; and (iv) distal tubular reabsorption dominated by the renin-angiotensin-aldosterone system (RAAS).
Flow-activated transport events along the nephron.
Review
Wang, New Haven, United States. In Curr Opin Nephrol Hypertens, 2006
SUMMARY: Flow-modulated NHE3 activity is the regulatory mechanism for GTB.
Kinetics of beta-lactam antibiotics synthesis by penicillin G acylase (PGA) from the viewpoint of the industrial enzymatic reactor optimization.
Review
Giordano et al., São Carlos, Brazil. In Biotechnol Adv, 2006
However, PGA may act either as a transferase or as a hydrolase, catalyzing two undesired side reactions: the hydrolysis of the acyl side-chain precursor (an ester or amide, a parallel reaction) and the hydrolysis of the antibiotic itself (a consecutive reaction).
Molecular genetic basis of the histo-blood group ABO system.
Impact
Hakomori et al., Seattle, United States. In Nature, 1990
The histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH).
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