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Microtubule associated tumor suppressor 1

A tip, GK1, MTUS1, Mitochondrial tumor suppressor gene 1
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CAN, HAD, CD8, MHC
Papers using A tip antibodies
Counting antigen-specific CD8 T cellsa reevaluation of bystander activation during viral infection
Bevan Michael J. et al., In The Journal of Experimental Medicine, 1997
(clone 30-H12), anti-CD8α (clone 53-6.7), and anti-CD4 (clone GK1.5), followed by lysis with low-tox-M rabbit complement (Cedarlane Labs) ...
Papers on A tip
MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations.
Celik et al., Muğla, Turkey. In Tumour Biol, Jan 2016
Here, expression levels of tumor suppressor microtubule-associated tumor suppressor 1 (MTUS1) and its regulatory miRNAs were reported.
CD4 T cell knockout does not protect against kidney injury and worsens cancer.
Edelstein et al., Aurora, United States. In J Mol Med (berl), Jan 2016
Mice depleted of CD4 T cells using the GK1.5 antibody were not protected against AKI and had larger tumors and lesser response to cisplatin.
Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study.
Kayani et al., Islamabad, Pakistan. In Plos One, Dec 2015
A family of orthologues of yeast silent information regulator 3 (SIRT3), 4 (SIRT4) and mitochondrial tumor suppressor 1 (MTUS1) are important mitochondrial tumor suppressor genes which play an important role in the progression of multiple cancers.
Over-expression of EPS15 is a favorable prognostic factor in breast cancer.
Zhang et al., Wuxi, China. In Mol Biosyst, Nov 2015
Among the neighboring genes of these SNPs, five (MTUS1, DOCK5, MSRA, SLIT3 and SKAP1) are genetically connected with EPS15 and its physical partners.
Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ.
Horiuchi et al., Japan. In Am J Hypertens, Nov 2015
Therefore, this study aimed to investigate the vascular protective effect of the AT2 receptor with activation of PPARγ involving AT2 receptor-interacting protein (ATIP).
A Comparison of Three Different Thick Epinucleus Removal Techniques in Cataract Surgery.
Kim et al., Ch'unch'ŏn, South Korea. In Semin Ophthalmol, Sep 2015
METHODS: Ninety eyes with thick adhesive epinuclei were randomly subdivided into three groups according to epinucleus removal technique: epinucleus floating (safe boat) technique, 30 patients; I/A tip, 30 patients; and phaco tip, 30 patients.
Genetic and functional characterization of clonally derived adult human brown adipocytes.
Kajimura et al., San Francisco, United States. In Nat Med, Apr 2015
In addition, we identified molecular markers that were highly enriched in UCP1-positive human adipocytes, a set that included potassium channel K3 (KCNK3) and mitochondrial tumor suppressor 1 (MTUS1).
Genome-Wide Analysis of Oceanimonas sp. GK1 Isolated from Gavkhouni Wetland (Iran) Demonstrates Presence of Genes for Virulence and Pathogenicity.
Salekdeh et al., Tehrān, Iran. In Cell J, 2014
sp.) GK1 is a member of the Aeromonadaceae family and its genome represents several virulence genes involved in fish and human pathogenicity.
Regulation of angiotensin II receptors beyond the classical pathway.
Mogi et al., Japan. In Clin Sci (lond), 2012
ATRAP (AT(1)-receptor-associated protein) and ATIP (AT(2)-receptor-interacting protein) are well-characterized AngII-receptor-associated proteins.
Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease.
Seibold et al., Erlangen, Germany. In Int J Oncol, 2012
Reports the first generation of a MTUS1 KO mouse, developing spontaneous heart hypertrophy and increased cell proliferation, confirming once more the anti-proliferative effect of MTUS1, and a SLE-like lymphoproliferative disease.
Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma.
Zhou et al., Guangzhou, China. In Mol Oncol, 2012
MTUS1 plays major roles in the progression of oral tongue squamous cell carcinoma.
Gene sequencing and tissue expression of unknown isoforms of an angiotensin II type 2 receptor interacting protein, ATIP, in the rat.
Louis et al., Melbourne, Australia. In Biosci Biotechnol Biochem, 2010
Expression levels of isoformes ATIP3 and ATIP4 in rat tissues were examined. There was little similarity in the relative tissue distribution of the various ATIP isoforms in rat and human
Angiotensin II and the vascular phenotype in hypertension.
Touyz et al., Roma, Italy. In Expert Rev Mol Med, 2010
These receptors are regulated by the GPCR-interacting proteins ATRAP, ARAP1 and ATIP.
An ATIPical family of angiotensin II AT2 receptor-interacting proteins.
Nahmias et al., Paris, France. In Trends Endocrinol Metab, 2010
Recent findings that ATIPs and ATIP-related proteins associate with microtubules suggest that they might constitute a novel family of multifunctional proteins regulating a wide range of physiopathological functions.
Expression and function of ATIP/MTUS1 in human prostate cancer cell lines.
Louis et al., Melbourne, Australia. In Prostate, 2010
Results in human prostate cancer cell lines demonstrate the presence of ATIP in both cell lines examined.
Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology.
Barany et al., New York City, United States. In J Mol Diagn, 2010
Among the often down-regulated, poor prognosis-associated 8p genes is MTUS1, whose gene product (a mitotic spindle-associated protein) was recently demonstrated to have a tumor suppressive property.
Down-regulation of MTUS1 in human colon tumors.
Seibold et al., Würzburg, Germany. In Oncol Rep, 2010
MTUS1 could be involved in the loss of proliferative control in human colon cancer
Chromosome copy number variation and breast cancer risk.
Burwinkel et al., Heidelberg, Germany. In Cytogenet Genome Res, 2007
An example of a CNV affecting the tumor suppressor gene MTUS1 that has been shown to be associated with familial breast cancer risk is given.
Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells.
Morse et al., In Nature, 1987
We report here that C57BL/6J (B6) and AKR/J mice, when functionally depleted of CD4+ cells by in vivo treatment with the CD4+-specific rat monoclonal antibody GK1.5 (refs 8-14) responded to ectromelia virus infection by developing an optimal in vivo virus-specific CTL response, and subsequently recovered from the disease (mousepox) that was lethal for similarly infected nude mice (CD4-, CD8-).
Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker.
Steinman et al., In Science, 1985
Administration of a monoclonal antibody (GK1.5) that recognizes the L3T4 marker present on helper T cells prevented the development of experimental allergic encephalomyelitis (EAE) in mice.
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