gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Olfactory receptor 744

a G-protein-coupled receptor
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, GPCR, CAN, V1a, HAD
Papers on a G-protein-coupled receptor
Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.
Gorojankina, Gif-sur-Yvette, France. In Cell Mol Life Sci, Feb 2016
Here I review published data and present a novel model of vertebrate Hh signaling suggesting that Smoothened (Smo) functions as a G-protein-coupled receptor in cilia.
A Novel Gene Controlling the Timing of Courtship Initiation in Drosophila melanogaster.
French et al., San José, Costa Rica. In Genetics, Jan 2016
Tre1 encodes a G-protein-coupled receptor required for establishment of cell polarity and cell migration, and has previously not been shown to be involved in courtship behavior.
Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group.
Pepper et al., Pretoria, South Africa. In Mol Genet Genomic Med, Jan 2016
Mutations in the melanocortin 4 receptor (MC4R) gene, which codes for a G-protein-coupled receptor responsible for postprandial satiety signaling, have been associated with monogenic obesity.
Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection.
Dingemanse et al., Allschwil, Switzerland. In Clin Pharmacokinet, Jan 2016
BACKGROUND AND OBJECTIVE: The chemoattractant receptor-homologous molecule expressed on T helper-2 cells (CRTH2) is a G-protein-coupled receptor for prostaglandin D2 (PGD2), a key mediator in inflammatory disorders.
The pre-vertebrate origins of neurogenic placodes.
Levine et al., Berkeley, United States. In Nature, Sep 2015
The Ciona PPE is shown to produce ciliated neurons that express genes for gonadotropin-releasing hormone (GnRH), a G-protein-coupled receptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests dual chemosensory and neurosecretory activities.
Thrombin stimulates insulin secretion via protease-activated receptor-3.
Rosengren et al., Barcelona, Spain. In Islets, Aug 2015
F2Rl2 is a G-protein-coupled receptor (GPCR) that encodes protease-activated receptor-3 (PAR3).
UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.
Harden et al., Chapel Hill, United States. In Mol Pharmacol, Jul 2015
We discuss here the broadly expressed P2Y14 receptor, a G-protein-coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.
Omega-3 polyunsaturated fatty acids as an angelus custos to rescue patients from NSAID-induced gastroduodenal damage.
Hahm et al., South Korea. In J Gastroenterol, Jun 2015
From the long history of willow tree bark and its extracts being applied for the relief of pain and fever, the synthesis of acetylsalicylic acid, the development of selective cyclooxygenase 2 inhibitors (coxibs), and the identification of a G-protein-coupled receptor for prostaglandin, the popular combination regimen of an NSAID and a proton pump inhibitor was invented, but development was continued for further improvement.
TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?
Häussinger et al., Düsseldorf, Germany. In Clin Rev Allergy Immunol, Jun 2015
TGR5 (Gpbar-1) is a G-protein-coupled receptor responsive to bile acids, which is expressed in cholangiocytes, intestinal epithelial cells, and macrophages of the liver and intestine as well as in CD14-positive monocytes of the peripheral blood.
The calcium sensing receptor: from calcium sensing to signaling.
Yang et al., Atlanta, United States. In Sci China Life Sci, 2015
The Ca(2+)-sensing receptor (the CaSR), a G-protein-coupled receptor, regulates Ca(2+) homeostasis in the body by monitoring extracellular levels of Ca(2+) ([Ca(2+)]o) and responding to a diverse array of stimuli.
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
Stratakis et al., Aş Şanamayn, Syria. In N Engl J Med, 2015
Only one of these genes, GPR101, which encodes a G-protein-coupled receptor, was overexpressed in patients' pituitary lesions.
Reciprocal interaction between bone and gonads.
Oury et al., Paris, France. In Arch Biochem Biophys, 2014
On the other hand, bone returns this favor to the gonads, through the secretion of osteocalcin (Ocn), which promotes testosterone biosynthesis following its binding to Gprc6a, a G-protein-coupled receptor.
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Okada et al., San Diego, United States. In Nature, 2014
Human GPR40 receptor (hGPR40), also known as free fatty-acid receptor 1 (FFAR1), is a G-protein-coupled receptor that binds long-chain free fatty acids to enhance glucose-dependent insulin secretion.
Visualization of arrestin recruitment by a G-protein-coupled receptor.
Lefkowitz et al., Durham, United States. In Nature, 2014
G-protein-coupled receptors (GPCRs) are critically regulated by β-arrestins, which not only desensitize G-protein signalling but also initiate a G-protein-independent wave of signalling.
Cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways.
Pande et al., Stanford, United States. In Nat Chem, 2014
Moreover, our models provide an atomistic description of the activation of a G-protein-coupled receptor and reveal multiple activation pathways.
share on facebooktweetadd +1mail to friends