a G-protein-coupled receptor
The pre-vertebrate origins of neurogenic placodes.
Berkeley, United States. In Nature, Sep 2015
The Ciona PPE is shown to produce ciliated neurons that express genes for gonadotropin-releasing hormone (GnRH), a G-protein-coupled receptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests dual chemosensory and neurosecretory activities.
Omega-3 polyunsaturated fatty acids as an angelus custos to rescue patients from NSAID-induced gastroduodenal damage.
South Korea. In J Gastroenterol, Jun 2015
From the long history of willow tree bark and its extracts being applied for the relief of pain and fever, the synthesis of acetylsalicylic acid, the development of selective cyclooxygenase 2 inhibitors (coxibs), and the identification of a G-protein-coupled receptor for prostaglandin, the popular combination regimen of an NSAID and a proton pump inhibitor was invented, but development was continued for further improvement.
TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?
Düsseldorf, Germany. In Clin Rev Allergy Immunol, Jun 2015
TGR5 (Gpbar-1) is a G-protein-coupled receptor responsive to bile acids, which is expressed in cholangiocytes, intestinal epithelial cells, and macrophages of the liver and intestine as well as in CD14-positive monocytes of the peripheral blood.
The calcium sensing receptor: from calcium sensing to signaling.
Atlanta, United States. In Sci China Life Sci, 2015
The Ca(2+)-sensing receptor (the CaSR), a G-protein-coupled receptor, regulates Ca(2+) homeostasis in the body by monitoring extracellular levels of Ca(2+) ([Ca(2+)]o) and responding to a diverse array of stimuli.
Reciprocal interaction between bone and gonads.
Paris, France. In Arch Biochem Biophys, 2014
On the other hand, bone returns this favor to the gonads, through the secretion of osteocalcin (Ocn), which promotes testosterone biosynthesis following its binding to Gprc6a, a G-protein-coupled receptor.