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Olfactory receptor 544

a G protein-coupled receptor
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GPCR, CAN, V1a, ACID, HAD
Papers on a G protein-coupled receptor
KISS1R signaling promotes invadopodia formation in human breast cancer cell via β-arrestin2/ERK.
Bhattacharya et al., London, Canada. In Cell Signal, Jan 2016
UNASSIGNED: Kisspeptins (KPs), peptide products of the KISS1 gene are endogenous ligands for the kisspeptin receptor (KISS1R), a G protein-coupled receptor.
Recycling and Endosomal Sorting of Protease-activated Receptor-1 is Distinctly Regulated by Rab11A and Rab11B.
Trejo et al., San Diego, United States. In J Biol Chem, Jan 2016
UNASSIGNED: Protease-activated receptor-1 (PAR1) is a G protein-coupled receptor that undergoes proteolytic irreversible activation by coagulant and anti-coagulant proteases.
Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells.
Beck-Sickinger et al., Leipzig, Germany. In J Pept Sci, Dec 2015
For potential use in clinical applications, we aimed to investigate the fate of the peptide ligand after binding and activation of the adrenomedullin receptor (AM1 ), a heterodimer consisting of the calcitonin receptor-like receptor (CLR), a G protein-coupled receptor, associated with the receptor activity-modifying protein 2 (RAMP2).
Human Cytomegalovirus Up-Regulates Endothelin Receptor Type B: Implication for Vasculopathies?
Söderberg-Nauclér et al., Vienna, Austria. In Open Forum Infect Dis, Dec 2015
Both endothelin receptor type B ([ETBR], a G protein-coupled receptor that mediates the vascular effects of the potent vasoconstrictor endothelin-1) and human cytomegalovirus ([HCMV], a ubiquitous herpesvirus) have been implicated in the pathogenesis of cardiovascular disease (CVD).
Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity.
Li et al., Chengdu, China. In J Genet Genomics, Dec 2015
Sphingosine-1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor (GPCR), controls vascular stability by stabilizing vascular endothelial (VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2 (VEGFR2) signaling.
Sonidegib: First Global Approval.
Burness, Auckland, New Zealand. In Drugs, Sep 2015
SMO is a G protein-coupled receptor-like molecule that is essential for the actions of the Hedgehog family of secreted proteins, which play a critical role in the development and homeostasis of many organs and tissues.
Calcimimetic and Calcilytic Drugs: Feats, Flops, and Futures.
Goodman et al., Toronto, Canada. In Calcif Tissue Int, Sep 2015
UNASSIGNED: The actions of extracellular Ca(2+) in regulating parathyroid gland and kidney functions are mediated by the extracellular calcium receptor (CaR), a G protein-coupled receptor.
Lipoxins and aspirin-triggered lipoxins in resolution of inflammation.
Recchiuti et al., Chieti, Italy. In Eur J Pharmacol, Sep 2015
Counter-regulatory signaling by LXA4 and 15-epi-LXA4 follows the activation of a G protein-coupled receptor, termed ALX/FPR2, which is emerging as a key anti-inflammatory receptor.
Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.
Cherezov et al., Los Angeles, United States. In Cell, Jun 2015
Angiotensin II type 1 receptor (AT(1)R) is a G protein-coupled receptor that serves as a primary regulator for blood pressure maintenance.
7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases.
Liu et al., San Diego, United States. In Front Pharmacol, 2014
The identification of 7α, 25-OHC as a G protein-coupled receptor ligand revealed a previously unknown signaling system of oxysterols, a class of molecules which exert profound biological functions.
The role of serotonin 5-HT2A receptors in memory and cognition.
Stackman et al., Hefei, China. In Front Pharmacol, 2014
In addition to its traditional activity as a G protein-coupled receptor (GPCR), recent studies have defined novel operations of 5-HT2ARs.
Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.
Ewbank et al., Marseille, France. In Nat Immunol, 2014
Using a genome-wide RNA-mediated interference (RNAi) screen, we identified the G protein-coupled receptor (GPCR) DCAR-1 as being required for the response to fungal infection and wounding.
Backbone modification of a polypeptide drug alters duration of action in vivo.
Gellman et al., Madison, United States. In Nat Biotechnol, 2014
Using an agonist of parathyroid hormone receptor-1 (PTHR1), a G protein-coupled receptor in the B-family, we present an approach for α→β residue replacement that enables both high activity and improved pharmacokinetic properties in vivo.
Probing single biomolecules in solution using the anti-Brownian electrokinetic (ABEL) trap.
Moerner et al., Stanford, United States. In Acc Chem Res, 2012
We have applied the ABEL trap method to explore the photodynamics and enzymatic properties of a variety of biomolecules in aqueous solution and present four examples: the photosynthetic antenna allophycocyanin, the chaperonin enzyme TRiC, a G protein-coupled receptor protein, and the blue nitrite reductase redox enzyme.
Endocrine regulation of male fertility by the skeleton.
Karsenty et al., New York City, United States. In Cell, 2011
By binding to a G protein-coupled receptor expressed in the Leydig cells of the testes, osteocalcin regulates in a CREB-dependent manner the expression of enzymes that is required for testosterone synthesis, promoting germ cell survival.
The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.
Luetje et al., Miami, United States. In J Biol Chem, 2007
A network of 8 residues in transmembrane domains III, V, and VI was identified forming part of the ligand binding pocket of MOR42-3
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