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Lectin, galactoside-binding, soluble, 3 binding protein

90K, Mac-2 binding protein
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: CD45, galectin-3, HAD, CAN, ACID
Papers on 90K
Electron spin echo envelope modulation of molecular motions of deuterium nuclei.
New
Dzuba et al., Novosibirsk, Russia. In J Magn Reson, Dec 2015
Between 90K and 120K, the ESEEM spectra change drastically.
Daclatasvir and asunaprevir treatment improves liver function parameters and reduces liver fibrosis markers in chronic hepatitis C patients.
New
Chayama et al., Hiroshima, Japan. In Hepatol Res, Dec 2015
We measured liver function parameters, serum alanine aminotransferase (ALT) and albumin levels and liver fibrosis markers, hyaluronic acid, type IV collagen and Mac-2 binding protein (M2BPGi) before and after (median 27 months, range of 17-47) completion of the treatment in SVR and non-SVR patients.
[Change in Serum Levels of New Hepatic Fibrosis Marker "Mac-2 Binding Protein Glycosylation isomer (M2BPGi)" in Patients with Chronic Hepatitis C during the Treatment of Pegylated Interferon and Ribavirin].
New
Seishima et al., In Rinsho Byori, Aug 2015
Recently, Mac-2 binding protein glycosylation isomer (M2BPGi) was identified as a novel hepatic fibrosis marker.
Genome-Wide Linkage Mapping of QTL for Yield Components, Plant Height and Yield-Related Physiological Traits in the Chinese Wheat Cross Zhou 8425B/Chinese Spring.
He et al., Harbin, China. In Front Plant Sci, 2014
In the present study, 246 F8 RILs derived from the cross of Zhou 8425B/Chinese Spring were genotyped using the high-density Illumina iSelect 90K single nucleotide polymorphism (SNP) assay.
Investigations Into the Interactions of a MALDI Matrix with Organic Thin Films Using C60 (+) SIMS Depth Profiling.
Winograd et al., Penn Hills, United States. In Surf Interface Anal, 2014
The results show successful depth profiles when taken at 90K.
The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions.
Review
Vaheri et al., Tampere, Finland. In Antiviral Res, 2013
Several biomarkers of disease severity have recently been discovered: interleukin-6, pentraxin-3, C-reactive protein, indoleamine 2,3-dioxygenase, cell-free DNA, soluble urokinase-type plasminogen activator, GATA-3 and Mac-2 binding protein.
Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion.
GeneRIF
Umezawa et al., Yokohama, Japan. In Oncol Rep, 2012
results show that NF-kappaB regulated the expression of G3BP and that G3BP increased the adhesion of T47D breast cancer cells to fibronectin
Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6.
GeneRIF
Svinartchouk et al., France. In J Virol, 2012
Adeno-associated virus type 6 interacts with G3BP in human and dog sera but not in macaque serum.
Serum levels of cytoplasmic melanoma-associated antigen at diagnosis may predict clinical relapse in neuroblastoma patients.
GeneRIF
Pistoia et al., Genova, Italy. In Cancer Immunol Immunother, 2011
LGALS3BP gene was expressed by neuroblatoma cell lines and patients' neuroblasts
Development of glycoprotein capture-based label-free method for the high-throughput screening of differential glycoproteins in hepatocellular carcinoma.
GeneRIF
Zou et al., Dalian, China. In Mol Cell Proteomics, 2011
serum changes of three glycoproteins, galectin-3 binding protein, insulin-like growth factor binding protein 3, and thrombospondin 1, was associated with the development of hepatocellular carcinoma
Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas.
GeneRIF
Kawasaki et al., Japan. In J Biol Chem, 2011
Mac-2BP was detected as a predominant DC-SIGN ligand expressed on some primary colorectal cancer tissues
90K (Mac-2 BP) and galectins in tumor progression and metastasis.
Review
GeneRIF
Iacobelli et al., Chieti, Italy. In Glycoconj J, 2003
REVIEW: role in tumor progression and metastasis
Molecular interpretation of ERK signal duration by immediate early gene products.
Impact
Blenis et al., Boston, United States. In Nat Cell Biol, 2002
However, when ERK signalling is sustained, c-Fos is phosphorylated by still-active ERK and RSK (90K-ribosomal S6 kinase).
AMPA receptor antagonists.
Review
Kornberg et al., Ann Arbor, United States. In Curr Med Chem, 2001
The quinoxaline-2,3-dione template has been the backbone of various competitive AMPA receptor antagonists such as NBQX, PNQX, YM-90K and more recently ZK200775.
IKAP is a scaffold protein of the IkappaB kinase complex.
Impact
Baeuerle et al., San Francisco, United States. In Nature, 1998
IKK-alpha and IKK-beta isozymes are found in large complexes of relative molecular mass 700,000-900,000 (M(r) 70K-90K), but little is known about other components that organize and regulate these complexes.
Distinct functions for the two importin subunits in nuclear protein import.
Impact
Laskey et al., Cambridge, United Kingdom. In Nature, 1995
The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran.
Structural investigations of recently discovered high Tc superconductors.
Review
Raveau et al., Antwerp, Belgium. In Microsc Res Tech, 1995
This cuprate belongs to the 1212 series; susceptibility measurements show a Tc (onset) of 90K, with a diamagnetic volume fraction of 27% at 4.2K to be reached.
Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin.
Impact
Rosen et al., San Francisco, United States. In Nature, 1993
Two lymph node ligands for L-selectin have been identified as sulphated glycoproteins of M(r) approximately 50K and approximately 90K, called Sgp50 and Sgp90 (ref.
[Cellular stress response in the eye].
Review
Wakakura, In Nihon Ganka Gakkai Zasshi, 1989
Three are described in terms of their molecular weights of 90K, 70K and 20--30K daltons, respectively, and a fourth is known as ubiquitin.
Homology of Ti alpha-subunit of a T-cell antigen-MHC receptor with immunoglobulin.
Impact
Reinherz et al., In Nature, 1984
Human T-cell receptors for antigen and major histocompatibility complex (MHC) determinants have now been defined on inducer, suppressor, and class 1 and class 2 MHC-specific cytotoxic T lymphocytes as T3-associated clonotypic molecules (Ti) of relative molecular mass 90,000 (90K) composed of one 49-54K alpha- and one 43K beta-subunit which are disulphide-linked.
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