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Ribosomal protein S6 kinase, polypeptide 4

90-kDa, MSK2
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Hsp90, ACID, CAN, HAD, fibrillin-1
Papers on 90-kDa
Biological relevance of Hsp90-binding immunophilins in cancer development and treatment.
Review
New
Galigniana et al., Buenos Aires, Argentina. In Int J Cancer, Mar 2016
Among these extra domains, the TPR-domain is perhaps the most relevant because it permits the interaction of high molecular weight immunophilins with the 90-kDa heat-shock protein, Hsp90.
Anti-Hsp90 therapy in autoimmune and inflammatory diseases: a review of preclinical studies.
New
Węgrzyn et al., Gdańsk, Poland. In Cell Stress Chaperones, Feb 2016
UNASSIGNED: Heat shock protein 90 (Hsp90), a 90-kDa molecular chaperone, is responsible for biological activities of key signaling molecules (clients) such as protein kinases, ubiquitin ligases, steroid receptors, cell cycle regulators, and transcription factors regulating various cellular processes, including growth, survival, differentiation, and apoptosis.
Suppressive Activity of Quercetin on Periostin Functions In Vitro.
New
Asano et al., Yokohama, Japan. In In Vivo, Feb 2016
UNASSIGNED: Periostin, a 90-kDa extracellular matrix protein, has been attracting attention as a novel biomarker of airway inflammatory diseases such as allergic rhinitis (AR) and asthma.
Green Turtles (Chelonia mydas) Have Novel Asymmetrical Antibodies.
New
Berestecky et al., Honolulu, United States. In J Immunol, Jan 2016
Using immunoassays with isotype-specific mAbs, in this study we show that green turtles (Chelonia mydas) have a 5.7S 120-kDa IgY comprising two equally sized H/L chains with truncated Fc and a 7S 200-kDa IgY comprised of two differently sized H chains bound to L chains and apparently often noncovalently associated with an antigenically related 90-kDa moiety.
A simple diagnostic index comprising epithelial membrane antigen and fibronectin for hepatocellular carcinoma.
New
El Naggar et al., Damietta, Egypt. In Ann Hepatol, Nov 2015
As a result, a single immunoreactive band was shown at 130-kDa and 90-kDa corresponding to EMA and fibronectin, respectively.
Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells.
New
Nagashima, Tsukuba, Japan. In Environ Toxicol Pharmacol, Nov 2015
In addition, to examine whether the molecular chaperone 90-kDa heat shock protein (Hsp90) contributes to rubratoxin B toxicity, the effects of Hsp90-specific inhibitors, radicicol and geldanamycin, were investigated.
Breakdown of albumin and haemalbumin by the cysteine protease interpain A, an albuminase of Prevotella intermedia.
Smalley et al., Long Beach, United States. In Bmc Microbiol, 2014
The bacterium expresses a 90-kDa cysteine protease termed interpain A (InpA) which both oxidizes and subsequently degrades haemoglobin, releasing haem.
Mouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 Residue.
Suh et al., Taegu, South Korea. In Plos One, 2014
In this study, we investigated the phosphorylation-dependent regulation of mouse sphingosine kinase (mSK) isoforms 1 and 2. mSK1a was robustly phosphorylated in response to extracellular stimuli such as phorbol ester, whereas mSK2 exhibited a high basal level of phosphorylation in quiescent cells regardless of agonist stimulation.
Boletus edulis Nitrite Reductase Reduces Nitrite Content of Pickles and Mitigates Intoxication in Nitrite-intoxicated Mice.
Ng et al., Beijing, China. In Sci Rep, 2014
A 90-kDa nitrite reductase (NiR), demonstrating peptide sequence homology to fungal nitrite reductase, was isolated from B. edulis fruiting bodies.
Expressions and roles of periostin in otolaryngological diseases.
Review
Izuhara et al., Yamagata, Japan. In Allergol Int, 2014
Periostin is a 90-kDa member of the fasciclin-containing family; it functions as part of matricellular proteins, and its production by airway epithelial cells is induced by IL-4 and IL-13.
Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52.
Review
Galigniana et al., Buenos Aires, Argentina. In Curr Protein Pept Sci, 2014
Their ability to interact via their TPR domains with the 90-kDa heat-shock protein, and through this chaperone, with several signalling cascade factors is of particular importance.
Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression.
Review
Galigniana et al., Buenos Aires, Argentina. In Biochim Biophys Acta, 2014
Hsp90 is a 90-kDa molecular chaperone that represents the major soluble protein of the cell.
cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance.
Review
Avkiran et al., London, United Kingdom. In J Muscle Res Cell Motil, 2012
Although much of the work to date on phospho-regulation of cMyBP-C has focused on the role of protein kinase A (PKA, also known as cAMP-dependent protein kinase), recent evidence suggests that a number of non-PKA serine/threonine kinases, such as Ca(2+)/calmodulin-dependent protein kinase II, protein kinase C, protein kinase D and the 90-kDa ribosomal S6 kinase are also capable of targeting this key regulatory sarcomeric protein.
Characterization of the cellular action of the MSK inhibitor SB-747651A.
GeneRIF
Arthur et al., Dundee, United Kingdom. In Biochem J, 2012
Comparison of the effects of SB-747651A, both in vitro and in cells, demonstrated that SB-747651A exhibited improved selectivity over H89 and Ro 31-8220 and therefore represents a useful tool to study MSK function in cells.
HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2.
GeneRIF
Ahn et al., South Korea. In Biochem Biophys Res Commun, 2011
MSK2 functions as an adaptor in mediating PKR activation, apparently independent of its catalytic activity.
Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.
GeneRIF
Johansen et al., Århus, Denmark. In Cancer Invest, 2011
These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.
The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.
GeneRIF
Johansen et al., Århus, Denmark. In Exp Dermatol, 2011
MSK1/2 are involved in the activation of feedback mechanisms that dampen oxazolone-induced skin inflammation.
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.
GeneRIF
Hansen et al., Copenhagen, Denmark. In Mol Cell, 2010
MSK1- and MSK2-mediated H3K27me3S28 phosphorylation serves as a mechanism to activate a subset of PcG target genes determined by the biological stimuli and thereby modulate the gene expression program determining cell fate.
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling.
Impact
Arthur et al., Dundee, United Kingdom. In Nat Immunol, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases.
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.
Impact
Ruden et al., Philadelphia, United States. In Nat Genet, 2003
Morphological alterations have been shown to occur in Drosophila melanogaster when function of Hsp90 (heat shock 90-kDa protein 1alpha, encoded by Hsp83) is compromised during development.
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