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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphodiesterase 1B, Ca2+-calmodulin dependent

63-kDa, PDE1B, PDE1B1
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: ACID, Phosphodiesterase, CAN, HAD, PDE
Papers on 63-kDa
Isolation and characterization of a serine protease-producing marine bacterium Marinomonas arctica PT-1.
New
Park et al., South Korea. In Bioprocess Biosyst Eng, Feb 2016
The molecular weight of the purified ProA was estimated to be 63-kDa as a major band by SDS-PAGE.
Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies.
New
Torres et al., Rochester, United States. In J Am Soc Nephrol, Oct 2015
In Pkd2(-/WS25) mice, knockout of Pde1a, Pde1c, or Pde3a but not of Pde1b or Pde3b aggravated the development of PKD and was associated with higher levels of protein kinase A-phosphorylated (Ser133) cAMP-responsive binding protein (P-CREB), activating transcription factor-1, and CREB-induced CRE modulator proteins in kidney nuclear preparations.
Ion conductance of the stem of the anthrax toxin channel during lethal factor translocation.
New
Finkelstein et al., United States. In J Mol Biol, Apr 2015
PA63 (the 63-kDa, C-terminal part of protective antigen) forms heptameric channels in cell membranes that allow for the transport of LF and edema factor into the cytosol.
A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.
New
Shoemaker et al., Bethesda, United States. In J Biol Chem, Apr 2015
This antibody inhibits conversion of the PA oligomer from "pre-pore" to its SDS and heat-resistant "pore" conformation while not preventing cleavage of full-length 83-kDa PA (PA83) by cell surface proteases to its oligomer-competent 63-kDa form (PA63).
Phosphodiesterase isoenzymes in the human urethra: a molecular biology and functional study.
Ückert et al., Hannover, Germany. In Eur J Pharmacol, 2014
RT-PCR analysis revealed the expression of PDE1B, PDE1C, PDE4A, PDE4C, PDE4D, PDE5A and PDE11A.
Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity.
Damme et al., Hamburg, Germany. In J Biol Chem, 2014
The 63-kDa single-chain precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum.
[Molecular model of anthrax toxin translocation into target-cells].
Review
Noskov, In Bioorg Khim, 2014
PA83 is cleaved by cell surface protease furin to produce a 63-kDa fragment (PA63).
Recombinant expression and characterization of a novel endoglucanase from Bacillus subtilis in Escherichia coli.
Jamil et al., Rāwalpindi, Pakistan. In Mol Biol Rep, 2014
The isolated putative endoglucanase gene consisted of an open reading frame of 1,701 nucleotides and encoded a protein of 567 amino acids with a molecular mass of 63-kDa.
Protection against Taenia pisiformis larval infection induced by a recombinant oncosphere antigen vaccine.
Yang et al., China. In Genet Mol Res, 2013
The full-length open reading frame of the TpUbc2 gene was 444 bp, and encoded a 16.63-kDa protein.
MicroRNA-378 controls classical brown fat expansion to counteract obesity.
Wang et al., Worcester, United States. In Nat Commun, 2013
At the molecular level, we find that miR-378 targets phosphodiesterase Pde1b in BAT but not in WAT.
Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease.
Mohamed et al., Kuala Lumpur, Malaysia. In Plos One, 2013
respectively, harbour the exportin 4 (XPO4) and phosphodiesterase 1B (PDE1B) genes which are already known to be involved in the etiology of liver cirrhosis and HCC.
Phosphodiesterases in neurodegenerative disorders.
Review
Prickaerts et al., Maastricht, Netherlands. In Iubmb Life, 2012
In Huntington's disease and Parkinson's disease, most research has focused on PDE1B and PDE10, because of their abundant presence in striatal neurons.
Genetic association of phosphodiesterase 1B (PDE1B) with carcass traits in Korean cattle.
GeneRIF
Chung et al., Wŏnju, South Korea. In Mol Biol Rep, 2012
The PDE1B gene is a candidate gene for carcass traits of beef cattle.
Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: biochemical and behavioral profiles of phosphodiesterase inhibition in dopaminergic neurotransmission.
Review
Snyder et al., Kurume, Japan. In J Pharmacol Sci, 2009
Multiple PDEs with different substrate specificities and subcellular localization are expressed in the striatum, and the functional roles of PDE10A, PDE4, and PDE1B are extensively studied.
Phosphodiesterase inhibitors as potential cognition enhancing agents.
Review
Schmidt, United States. In Curr Top Med Chem, 2009
This review provides a background for understanding the expanding literature in this field as well as a brief update on the rationale driving the search for selective inhibitors of targets such as PDE1B, PDE2, PDE5 and PDE9.
Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.
GeneRIF
Cooper et al., Cambridge, United Kingdom. In Cell Signal, 2008
These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i.
Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme.
GeneRIF
Repaske et al., United States. In Neuropharmacology, 2007
The present studies demonstrate increased striatal dopamine turnover in PDE1B knockout mice associated with increased baseline motor activity and an exaggerated locomotor response to dopaminergic stimulants such as methamphetamine and amphetamine.
Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice.
GeneRIF
Vorhees et al., Cincinnati, United States. In Genes Brain Behav, 2006
Data suggest a role for PDE1B in locomotor responses to psychostimulants through modulation of DARPP32-dependent pathways; however, this modulation does not necessarily impact other behaviors, such as anxiety or learning.
PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte.
GeneRIF
Beavo et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2006
PDE1B2 regulates a subset of phenotypic changes that occur upon phorbol-12-myristate-13-acetate-induced differentiation and likely also plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels
Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages.
Review
Beavo et al., Seattle, United States. In Neurochem Int, 2004
For example, we have recently found that PDE5 is expressed in all Purkinje neurons while PDE1B is expressed in only a subset of these neurons.
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