Genetics of ischemic stroke: An Indian scenario.
New Delhi, India. In Neurol India, Jan 2016
Combined linkage/association studies have demonstrated that genes encoding phosphodiesterase 4D (PDE4D) and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) confer risk for stroke.
Eicosanoid pathway in colorectal cancer: Recent updates.
Ankara, Turkey. In World J Gastroenterol, Dec 2015
Oftentimes, these autacoids work in an antagonistic and highly temporal manner in inflammation; therefore, inhibition of the pro-inflammatory COX-2 or 5-LOX enzymes may subsequently inhibit the formation of their essential products, or shunt substrates from one pathway to another, leading to undesirable side-effects.
Flavocoxid, a nutraceutical approach to blunt inflammatory conditions.
Messina, Italy. In Mediators Inflamm, 2013
Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro.
The structure of human 5-lipoxygenase.
Baton Rouge, United States. In Science, 2011
identified a 5-LOX-specific destabilizing sequence involved in orienting the carboxyl terminus, which binds the catalytic iron; report the crystal structure at 2.4 angstrom resolution of 5-LOX stabilized by replacement of this sequence
Southampton, United Kingdom. In Unknown Journal, 0001
Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5) gene promoter; where the wild type has five copies per allele, denoted here as 5/5, but variant genotypes may have 1–8 copies on each allele, denoted as x/x or 5/x, influences montelukast efficacy in asthmatic adults.