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Arachidonate 5-lipoxygenase

5-lipoxygenase, Arachidonate 5-Lipoxygenase, 5-LOX
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: lysyl oxidase, ACID, cyclooxygenase, CAN, Cyclooxygenase 2
Papers on 5-lipoxygenase
Dual Role of 5-Lipoxygenase in Osteoclastogenesis in Bacterial-induced Apical Periodontitis.
New
Faccioli et al., Ribeirão Preto, Brazil. In J Endod, Feb 2016
INTRODUCTION: The aim of this study was to evaluate the role of 5-lipoxigenase (5-LO) in the signaling for osteoclast formation and bone resorption in apical periodontitis (AP) after root canal contamination with oral bacteria.
Genetics of ischemic stroke: An Indian scenario.
New
Prasad et al., New Delhi, India. In Neurol India, Jan 2016
Combined linkage/association studies have demonstrated that genes encoding phosphodiesterase 4D (PDE4D) and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) confer risk for stroke.
Evaluating the inhibitory potential of Withania somnifera on platelet aggregation and inflammation enzymes: An in vitro and in silico study.
New
Hegdekatte et al., Mysore, India. In Pharm Biol, Jan 2016
Materials and methods Aqueous and ethanolic (1:1) leaf extracts were subjected to in vitro indirect haemolytic activity using Naja naja venom, human platelet aggregation was quantified for lipid peroxidation using arachidonic acid (AA) as agonist and 5-lipoxygenase (5-LOX) levels were determined using standard spectrometric assays.
Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.
New
Chen et al., Ningbo, China. In Oncol Rep, Jan 2016
In 94 colorectal cancer samples collected from the Han population, the immunohistochemical results indicated that 68% of the patients with colorectal cancer had a co-expression of both COX-2 and 5-LOX, while both displayed low expression in the matched normal tissues.
Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
New
Impact
Malanchi et al., London, United Kingdom. In Nature, Jan 2016
Genetic or pharmacological inhibition of the leukotriene-generating enzyme arachidonate 5-lipoxygenase (Alox5) abrogates neutrophil pro-metastatic activity and consequently reduces metastasis.
Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition.
New
Filosa et al., Napoli, Italy. In Eur J Med Chem, Jan 2016
UNASSIGNED: Following the results we previously reported on a series of ethyl 2-phenylthiomethyl 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase (5-LOX) inhibitors, in order to obtain a more selective compound with respect to the previous generation of derivatives, we decided to modify the structure of the core ligand.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Review
New
Okuyama et al., Tokyo, Japan. In Redox Biol, Dec 2015
5-LOX is a distinct isoform playing an important role in asthma and inflammation.
Eicosanoid pathway in colorectal cancer: Recent updates.
Review
New
Banerjee et al., Ankara, Turkey. In World J Gastroenterol, Dec 2015
Oftentimes, these autacoids work in an antagonistic and highly temporal manner in inflammation; therefore, inhibition of the pro-inflammatory COX-2 or 5-LOX enzymes may subsequently inhibit the formation of their essential products, or shunt substrates from one pathway to another, leading to undesirable side-effects.
D-002 (beeswax alcohols): concurrent joint health benefits and gastroprotection.
Review
New
Carbajal et al., Havana, Cuba. In Indian J Pharm Sci, Mar 2015
The search of safer substances for managing inflammatory conditions is updated, a challenge wherein dual COX/5-LOX inhibitors have a place.
Flavocoxid, a nutraceutical approach to blunt inflammatory conditions.
Review
Altavilla et al., Messina, Italy. In Mediators Inflamm, 2013
Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro.
Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
GeneRIF
Newcomer et al., Baton Rouge, United States. In Faseb J, 2012
phosphorylation of 5-LOX at S663 not only down-regulates leukotriene synthesis but also stimulates lipoxin production in inflammatory cells that do not express 15-LOX, redirecting lipid mediator biosynthesis to the production of mediators of inflammation.
Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans.
GeneRIF
Stephensen et al., Davis, United States. In J Nutr, 2012
These findings indicate that the efficacy of fish oil supplements vary by ALOX5 genotype.
Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis.
GeneRIF
Bäck et al., Stockholm, Sweden. In Febs Lett, 2012
evidence for epigenetic modifications of valvular interstitial cells in valvular heart disease
Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice.
GeneRIF
FitzGerald et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2012
deletion of the 5-lipoxygenase activating protein (FLAP) did not influence atherogenesis, it attenuated the proatherogeneic impact of COX-2 deletion in hyperlipidemic mice
Attenuation of cysteamine-induced duodenal ulcer with Cochinchina momordica seed extract through inhibiting cytoplasmic phospholipase A2/5-lipoxygenase and activating γ-glutamylcysteine synthetase.
GeneRIF
Hahm et al., Inch'ŏn, South Korea. In J Gastroenterol Hepatol, 2012
Cochinchina momordica seed extracts exerted significantly protective effect against cysteamine-induced duodenal ulcer by 5-lipoxygenase inhibition.
The structure of human 5-lipoxygenase.
Impact
GeneRIF
Newcomer et al., Baton Rouge, United States. In Science, 2011
identified a 5-LOX-specific destabilizing sequence involved in orienting the carboxyl terminus, which binds the catalytic iron; report the crystal structure at 2.4 angstrom resolution of 5-LOX stabilized by replacement of this sequence
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Impact
GeneRIF
Li et al., Worcester, United States. In Nat Genet, 2009
Study identifies the arachidonate 5-lipoxygenase (5-LO) gene (Alox5) as a critical regulator for leukemia stem cells (LSCs) in BCR-ABL-induced chronic myeloid leukemia (CML).
Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203.
Impact
Green et al., Baltimore, United States. In J Clin Oncol, 2008
We performed a randomized phase II trial to test the hypothesis that inhibitors of two eicosanoid pathways (cyclooxygenase-2 [COX-2], celecoxib and 5-lipoxygenase [5-LOX], zileuton) added to chemotherapy would improve outcome in advanced non-small-cell lung cancer (NSCLC).
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.
Impact
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2006
Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be associated with risk of myocardial infarction.
Review
Grigg et al., Southampton, United Kingdom. In Unknown Journal, 0001
Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5) gene promoter; where the wild type has five copies per allele, denoted here as 5/5, but variant genotypes may have 1–8 copies on each allele, denoted as x/x or 5/x, influences montelukast efficacy in asthmatic adults.
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