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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


G-protein coupled receptor for serotonin; found in nociceptors throughout the body [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: 5-HT1B, 5-HT1A, HAD, CAN, ACID
Papers on 5-HT1D
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.
Daley et al., Lafayette, United States. In Bioorg Med Chem Lett, Jan 2016
Five of the DALT compounds had affinity in the 50-400nM range for serotonin 5-HT1D, 5-HT6, and 5-HT7 receptors; again, it was the unsubstituted DALT that had the weakest affinity at all three subtypes.
Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures.
Sánchez et al., Paramus, United States. In Neuropharmacology, Jan 2016
The multimodal-acting antidepressant vortioxetine is an antagonist at 5-HT3, 5-HT7, and 5-HT1D receptors, a partial agonist at 5-HT1B receptors, an agonist at 5-HT1A receptors, and an inhibitor of the serotonin (5-HT) transporter (SERT) and has pro-cognitive properties.
Serotonergic regulation of distention-induced ATP release from the urothelium.
Kawatani et al., Ōsaka, Japan. In Am J Physiol Renal Physiol, Dec 2015
UNASSIGNED: 5-hydroxytryptamine (5-HT; serotonin) is involved in both motor and sensory functions in hollow organs, especially the gastrointestinal tract.
Serotonin induces peripheral mechanical antihyperalgesic effects in mice.
Romero et al., Belo Horizonte, Brazil. In Eur J Pharmacol, Dec 2015
We used selective antagonists of serotonin receptors (isamoltan 5-HT1B, BRL 15572 5-HT1D, ketanserin 5-HT2A, ondansetron 5-HT3 and SB-269970 5-HT7).
Regulatory Effects of 5-Hydroxytryptamine Receptors on Voiding Function.
Kawatani et al., Akita, Japan. In Adv Ther, Oct 2015
UNLABELLED: A growing body of evidence suggests that 5-hydroxytryptamine (5-HT; serotonin) has both physiological and pathological functions in the lower urinary tract.
5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin.
Bian et al., Guangzhou, China. In Mol Oncol, Oct 2015
UNASSIGNED: 5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown.
[Vortioxetine: a new antidepressant to treat depressive episodes].
Corruble et al., Le Kremlin-Bicêtre, France. In Encephale, Oct 2015
UNASSIGNED: Vortioxetine is a new antidepressant, which mechanism of action is multimodal, targeting the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3, 5-HT7 receptors and the serotonin transporter (5-HTT).
[A cell membrane chromatography method for investigation of 5-hydroxytryptamine receptor-ligustilide interaction].
Fan et al., In Se Pu, May 2015
A rat striatum cell membrane chromatography (CMC) frontal analysis method was developed for the determination of the equilibrium dissociation constants (KD) for 5-hydroxytryptamine (5-HT) receptor 5-HT1D-ligustilide interactions.
Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors).
Stahl, In Cns Spectr, Apr 2015
Vortioxetine is an antidepressant that targets multiple pharmacologic modes of action at sites--or nodes--where serotonergic neurons connect to various brain circuits.
Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data.
Artigas et al., Paramus, United States. In Pharmacol Ther, 2015
Vortioxetine, a novel antidepressant for the treatment of major depressive disorder (MDD), is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor.
The efficacy of vortioxetine for the treatment of major depressive disorder.
Sarvaiya et al., India. In Expert Rev Neurother, 2014
Vortioxetine is an agonist of 5-HT1A, a partial agonist of 5-HT1B and an antagonist of 5-HT1D, 5-HT3 and 5-HT7 serotoninergic receptors.
Vortioxetine for the treatment of major depressive disorder.
David et al., Châtenay-Malabry, France. In Expert Rev Clin Pharmacol, 2014
Vortioxetine (Brintellix(®), 1-[2-(2,4-dimethylphenyl-sulfanyl)-phenyl]-piperazine) is a multimodal antidepressant targeting the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3, 5-HT7 receptors and the serotonin (5-HT) transporter (5-HTT).
Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons.
Kullander et al., Uppsala, Sweden. In Mol Cell Neurosci, 2012
5-hydroxytryptamine (serotonin) receptor 1D is a novel marker for gamma motor neurons and that the 5-ht1d receptor is important to receive and relay accurate sensory information in developing and mature spinal cord motor circuits.
Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus.
Ebers et al., Toronto, Canada. In Neuroreport, 2012
study identified the presence of genetic association at chromosome 1p36 with migraine with aura (P=0.045, Bonferroni corrected): the locus encoding the 5HT(1D) receptor gene
[Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].
Wu et al., Shijiazhuang, China. In Zhonghua Yi Xue Za Zhi, 2011
The mRNA and protein expressions of 5-HT1D receptor decreased in excessive fatigue rats and restraint stress rats.
Distribution of 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor expression in rat trigeminal and dorsal root ganglia neurons: relevance to the selective anti-migraine effect of triptans.
Goadsby et al., San Francisco, United States. In Brain Res, 2010
5-HT(1B), 5-HT(1D)and 5-HT(1F) receptor expression are equally represented in trigeminal ganglia and the dorsal root ganglia.
Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.
Balaban et al., Chinju, South Korea. In Brain Res, 2010
vestibular ganglion cells were immunoreactive for 5-HT(1B) receptors in macaques and rats
Is chest pain after sumatriptan oesophageal in origin?
Fowler et al., Manchester, United Kingdom. In Lancet, 1994
3-5% of patients taking the 5HT1D agonist sumatriptan for migraine have chest discomfort, suggesting a cardiac origin.
A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors.
Ashkenazi et al., San Francisco, United States. In Nature, 1992
Neuropsychiatric disorders such as anxiety, depression, migraine, vasospasm and epilepsy may involve different subtypes of the 5-hydroxytryptamine (5-HT) receptor.
Treatment of acute migraine with subcutaneous sumatriptan.
Skaggs et al., Springfield, United States. In Jama, 1991
Sumatriptan succinate, a 5-HT1D receptor agonist, constricts human cranial arteries.
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