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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Htr1b 5-hydroxytryptamine (serotonin) receptor 1B

5-HT1B, S12
G-protein coupled receptor for serotonin; may have a role in learning and memory [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: 5-HT1A, HAD, 5-HT1D, CAN, TRIM32
Papers on 5-HT1B
Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum.
New
Greengard et al., New York City, United States. In Proc Natl Acad Sci U S A, Feb 2016
In the vSt, 5-HT1A (a postsynaptic receptor) and 5-HT1B (a presynaptic receptor) are highly expressed, and synergistically inhibit the excitability of ChIs.
Zolmitriptan Nasal Spray: A Review in Acute Migraine in Pediatric Patients 12 Years of Age or Older.
New
McKeage, Auckland, New Zealand. In Paediatr Drugs, Feb 2016
UNASSIGNED: The intranasal formulation of zolmitriptan, a selective serotonin 5-HT1B/1D agonist, was recently approved by the US Food and Drug Administration for the treatment of acute migraine in pediatric patients 12 years of age or older.
Challenges in developing drugs for primary headache.
Review
New
Ashina et al., Copenhagen, Denmark. In Prog Neurobiol, Feb 2016
The development of the triptan class of serotonin 5-HT1B/1D/1F receptor agonists has advanced our understanding of the neurobiology of migraine pain, which subsequently resulted in the development of calcitonin gene related peptide (CGRP) modulators that are now showing promise as acute and preventative anti-migraine agents.
New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders.
Review
New
De Deurwaerdère et al., Malta. In Pharmacol Ther, Jan 2016
Knowledge of its functional role in the CNS pathophysiology has been impaired for many years due to the lack of drugs capable of discriminating among 5-HT2R subtypes, and to a lesser extent to the 5-HT1B, 5-HT5, 5-HT6 and 5-HT7Rs.
Serotonin receptors in brain revisited.
Review
New
Palacios, Barcelona, Spain. In Brain Res, Jan 2016
In order to provide further support to the existence of these receptors we performed quantitative autoradiographic mapping of the binding of several ligands for the 5-HT1 receptor labeling the subtypes 5-HT1A, 5-HT1B and 5-HT1C, and characterize pharmacologically these different receptors.
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.
New
Daley et al., Lafayette, United States. In Bioorg Med Chem Lett, Jan 2016
The test drugs had even weaker affinity for 5-HT1B, 5-HT1E, and 5-HT5A subtypes and little or no affinity for the 5-HT3 subtype.
Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures.
New
Sánchez et al., Paramus, United States. In Neuropharmacology, Jan 2016
The multimodal-acting antidepressant vortioxetine is an antagonist at 5-HT3, 5-HT7, and 5-HT1D receptors, a partial agonist at 5-HT1B receptors, an agonist at 5-HT1A receptors, and an inhibitor of the serotonin (5-HT) transporter (SERT) and has pro-cognitive properties.
Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study.
New
Hay-Schmidt et al., Copenhagen, Denmark. In Neurosci Lett, Jan 2016
Autoradiography showed that serotonin receptors 5-HT1B and 5-HT2C and the serotonin transporter were present in STN, whereas the 5-HT1A and 5-HT2A not were present.
Chronic Exposure to Androgenic-Anabolic Steroids Exacerbates Axonal Injury and Microgliosis in the CHIMERA Mouse Model of Repetitive Concussion.
New
Wellington et al., Vancouver, Canada. In Plos One, Dec 2015
AAS treatment induced the expected physiological changes including increased body weight, testicular atrophy, aggression and downregulation of brain 5-HT1B receptor expression.
New therapeutic approaches for the prevention and treatment of migraine.
Review
New
Impact
Holle et al., Essen, Germany. In Lancet Neurol, Oct 2015
Other approaches targeting the transient receptor potential vanilloid (TRPV1) receptor, glutamate, GABAA receptors, or a combination of 5-HT1B/1D receptors and neuronal nitric oxide synthesis have been investigated but have not been successful in clinical trials thus far.
Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands.
Review
Sylte et al., Warsaw, Poland. In Int J Mol Sci, 2014
It should also be noted that the 5-HT1A receptor cooperates with other signal transduction systems (like the 5-HT1B or 5-HT2A/2B/2C receptors, the GABAergic and the glutaminergic systems), which also contribute to its antidepressant and/or anxiolytic activity.
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
Impact
Malenka et al., Stanford, United States. In Nature, 2013
Furthermore, oxytocin-induced synaptic plasticity requires activation of nucleus accumbens 5-HT1B receptors, the blockade of which prevents social reward.
Structural basis for molecular recognition at serotonin receptors.
Impact
Xu et al., Los Angeles, United States. In Science, 2013
Compared with the structure of the 5-HT2B receptor, the 5-HT1B receptor displays a 3 angstrom outward shift at the extracellular end of helix V, resulting in a more open extended pocket that explains subtype selectivity.
Structural features for functional selectivity at serotonin receptors.
Impact
Stevens et al., Los Angeles, United States. In Science, 2013
We report biochemical studies showing that the hallucinogen lysergic acid diethylamide, its precursor ergotamine (ERG), and related ergolines display strong functional selectivity for β-arrestin signaling at the 5-HT2B 5-hydroxytryptamine (5-HT) receptor, whereas they are relatively unbiased at the 5-HT1B receptor.
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.
Impact
Sobue et al., Nagoya, Japan. In Nat Med, 2012
Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models.
Age effects on serotonin receptor 1B as assessed by PET.
GeneRIF
Neumeister et al., New Haven, United States. In J Nucl Med, 2012
age is a relevant factor for 5-HT(1B) in the cortex of healthy adults
Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia--a pilot study.
GeneRIF
Pavlović et al., Zagreb, Croatia. In Genet Test Mol Biomarkers, 2012
Preliminary data imply that the genetic variants of the 5-HT1B receptor might be associated with prostate cancer
Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours.
GeneRIF
Abrahamsson et al., Malmö, Sweden. In Anticancer Res, 2012
staining pattern of serotonin receptors in ovary indicates functional role in ovarian physiology. In ovarian tumours, expression is in harmony with a tumour suppressor role in ovarian carcinogenesis, which is supported by observations in the literature
A study of possible associations between single nucleotide polymorphisms in the serotonin receptor 1A, 1B, and 2C genes and self-reported ejaculation latency time.
GeneRIF
Santtila et al., Turku, Finland. In J Sex Med, 2012
two SNPs, both serotonin receptor 5-HT(1B) linked, had a significant main effect on ejaculation latency time.
Interaction between serotonin transporter and serotonin receptor 1 B genes polymorphisms may be associated with antisocial alcoholism.
GeneRIF
Lu et al., Tainan City, Taiwan. In Behav Brain Funct, 2011
Neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism.
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