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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

5-hydroxytryptamine receptor 1A

5-HT1A, X5-HT1A
Top mentioned proteins: TRIM32, CAN, HAD, V1a, 5-HT1B
Papers on 5-HT1A
Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.
New
Koblan et al., Marlborough, United States. In Cns Spectr, Feb 2016
BACKGROUND: While extensive literature on the role of the serotonin receptor 1A (5-HT1A-R) in cognition exists, the findings are largely from animal studies.
Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine.
New
Halberstadt, San Diego, United States. In Pharmacol Biochem Behav, Feb 2016
5-MeO-DMT also disrupts PPI but the effect is primarily attributable to 5-HT1A activation.
Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties.
New
Klinea et al., Columbia, United States. In Brain Res, Feb 2016
5-HT7 receptor-mediated changes in excitatory postsynaptic currents were also altered by block of 5-HT1A and GABAA receptors.
The Novel 5-HT1A Receptor Agonist, NLX-112 Reduces L-DOPA-induced Abnormal Involuntary Movements in Rat: a Chronic Administration Study with Microdialysis Measurements.
New
Newman-Tancredi et al., Groningen, Netherlands. In Neuropharmacology, Feb 2016
The highly selective and efficacious 5-HT1A receptor agonist, NLX-112 (befiradol or F13640) shows potent activity in a rat model of LID (suppression of Abnormal Involuntary Movements, AIMs) but its anti-AIMs effects have not previously been investigated following repeated administration.
FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression.
Review
New
Fuxe et al., Stockholm, Sweden. In Trends Neurosci, Jan 2016
The discovery of brain fibroblast growth factor receptor 1 (FGFR1)-5 hydroxytryptamine receptor 1A (5-HT1A) heteroreceptor complexes, and their enhancement of neuroplasticity, offers an integration of these hypotheses at the molecular level.
Serotonin receptors in brain revisited.
Review
New
Palacios, Barcelona, Spain. In Brain Res, Jan 2016
In order to provide further support to the existence of these receptors we performed quantitative autoradiographic mapping of the binding of several ligands for the 5-HT1 receptor labeling the subtypes 5-HT1A, 5-HT1B and 5-HT1C, and characterize pharmacologically these different receptors.
Verbal memory and 5-HT1A receptors in healthy volunteers - A PET study with [carbonyl-(11)C]WAY-100635.
New
Hietala et al., Lahti, Finland. In Eur Neuropsychopharmacol, Jan 2016
UNASSIGNED: The serotonin 5-HT1A receptor is a putative drug development target in disorders with cognitive and in particular memory deficits.
Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator.
Review
New
Citrome et al., In Clin Schizophr Relat Psychoses, Dec 2015
Brexpiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A and at adrenergic alpha1B and alpha2C receptors.
5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma.
Review
New
Kline et al., Pittsburgh, United States. In Brain Res, Dec 2015
An approach that has undergone considerable empirical research after TBI is pharmacological targeting of 5-HT1A receptors with agonists such as repinotan HCl, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), and buspirone.
Phencyclidine-induced disruption of oscillatory activity in prefrontal cortex: Effects of antipsychotic drugs and receptor ligands.
New
Celada et al., Barcelona, Spain. In Eur Neuropsychopharmacol, Dec 2015
Atypical antipsychotic reversal may additionally involve 5-HT1A-R activation (but not 5-HT2A-R blockade) since 8-OH-DPAT and BAYx3702 (but not M100907) fully countered PCP effects.
Treatment for Hypoactive Sexual Desire.
New
Impact
Pfaus, Montréal, Canada. In Cell, Nov 2015
Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors.
Hippocampal 5-HT1A Receptor and Spatial Learning and Memory.
Review
Stout et al., Melbourne, Australia. In Front Pharmacol, 2014
The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5-hydroxytryptamine; 5-HT) receptor binding sites, particularly of the 1A receptor (5-HT1A) subtype.
Enhanced aggressive behavior in mice lacking 5-HT1B receptor.
Impact
Hen et al., Strasbourg, France. In Science, 1994
However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors.
The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor.
Impact
Lefkowitz et al., Durham, United States. In Nature, 1988
We now report that the protein product of the genomic clone, G21, transiently expressed in monkey kidney cells has all the typical ligand-binding characteristics of the 5-hydroxytryptamine (5-HT1A) receptor.
Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock.
Impact
Green et al., In Nature, 1985
Recently a new drug, 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT), has been identified which shows high selectivity for binding to 5-HT1 (possibly 5-HT1A) receptors and which binds to presynaptic serotonin autoreceptors in some regions of rat brain.
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