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Steroid-5-alpha-reductase, alpha polypeptide 1

Steroid 5-alpha-reductase (EC catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: MEN, aromatase, CAN, HAD, AGE
Papers on 5-alpha-Reductase
5-Alpha-reductase inhibitors in diseases of the prostate.
Wang et al., Boston, United States. In Curr Opin Endocrinol Diabetes Obes, 2014
PURPOSE OF REVIEW: To summarize the history of the use of 5-alpha-reductase inhibitors in the treatment of urologic diseases and discuss the current practices and indications for therapy.
Pharmacotherapy and herbal treatment of benign prostatic hyperplasia.
Zhang et al., Shanghai, China. In Front Biosci, 2013
5-Alpha-reductase inhibitors (5-ARIs) decrease the production of dihydrotestosterone within the prostate, which results in decreased prostate volume.
Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified.
Messenger et al., In Exp Dermatol, 2012
Based on a limited selection of gene variants, no involvement of SRD5A1, SRD5A2, ESR1, ESR2 or PGR in female pattern hair loss is evident.
SRD5A1 genotype frequency differences in women with mild versus severe premenstrual symptoms.
McCrone et al., Newark, United States. In Issues Ment Health Nurs, 2012
Ten percent of cases and 44% of controls had the cytosine/cytosine (C/C) genotype for the SRD5A1 SNP, rs501999 indicating that this genotype may protect women against severe premenstrual symptoms.
Polymorphism Thr160Thr in SRD5A1, involved in the progesterone metabolism, modifies postmenopausal breast cancer risk associated with menopausal hormone therapy.
Chang-Claude et al., Heidelberg, Germany. In Breast Cancer Res Treat, 2012
Postmenopausal breast cancer risk associated with combined therapy may be modified by genetic variation in SRD5A1
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer.
Sharifi et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2011
the dominant route of Dihydrotestosterone synthesis in castration-resistant prostate cancer bypasses testosterone, and instead requires 5alpha-reduction of androstenedione by SRD5A1 to 5alpha-androstanedione, which is then converted to DHT
Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.
Kim et al., Houston, United States. In Plos One, 2010
The different expression levels of 5alpha-reductase isoenzymes may confer response or resistance to 5alpha-reductase inhibitors.
Testosterone selectively affects aromatase and 5alpha-reductase activities in the green anole lizard brain.
Wade et al., East Lansing, United States. In Gen Comp Endocrinol, 2010
Aromatase converts T to estradiol and 5alpha-reductase converts T to 5alpha-dihydrotestosterone (DHT).
Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-alpha-reductase inhibitor: a treatment strategy for acne.
Hoffman et al., San Diego, United States. In J Dermatol, 2010
5-alpha-Reductase plays a critical role in normal and pathological androgen-dependent processes.
Does the combination of an alpha1-adrenergic antagonist with a 5alpha-reductase inhibitor improve urinary symptoms more than either monotherapy?
Wei et al., Ann Arbor, United States. In Curr Opin Urol, 2010
5alpha-Reductase inhibitors (ARIs) can halt the disease's progression.
A girl with tomboy behavior: lesson from misdiagnosis in a baby with ambiguous genitalia.
Bertelloni et al., Pisa, Italy. In Sex Dev, 2009
5alpha-Reductase-2 deficiency is a rare 46,XY disorder of sex differentiation caused by mutations in the 5alpha-reductase type 2 gene.
Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats.
Walker et al., Edinburgh, United Kingdom. In Plos One, 2009
5Alpha-reductase mRNA was increased on the low carbohydrate compared with the moderate carbohydrate diet.
Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001.
Seckl et al., United States. In Psychoneuroendocrinology, 2009
RESULTS: 5alpha-Reductase activity was significantly lower at pre-treatment among non-responders, whereas there were no significant pre-treatment differences between responders and non-responders in any other hormone or metabolite level.
Effects of environmental stress on mRNA and protein expression levels of steroid 5alpha-Reductase isozymes in adult rat brain.
Ortega et al., Granada, Spain. In Horm Behav, 2009
Steroid 5alpha-Reductase (5alpha-R) is the rate-limiting enzyme in the biosynthesis of 3alpha,5alpha-reduced neurosteroids.
Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.
Stewart et al., Birmingham, United Kingdom. In J Clin Endocrinol Metab, 2009
MAIN OUTCOME MEASURES: We measured urinary steroid metabolites including glucocorticoids and androgens and the ratios reflecting enzymatic activities involved in peripheral cortisol and androgen metabolism, 5 alpha-reductase, and 11 beta-hydroxysteroid dehydrogenase types 1 and 2. We also measured circulating levels of glucose, insulin, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and testosterone and calculated homeostasis model assessment.
Diagnosis of 5alpha-reductase 2 deficiency: a local experience.
Shek et al., Hong Kong, Hong Kong. In Hong Kong Med J, 2009
5Alpha-reductase 2 deficiency is an autosomal recessive disorder characterised by lack of masculinisation in XY individuals due to failure to convert testosterone to dihydrotestosterone, the bioactive androgen.
Genetic analysis of the SRD5A2 gene in Indian patients with 5alpha-reductase deficiency.
Bhatia et al., Lucknow, India. In J Pediatr Endocrinol Metab, 2009
It results from impaired conversion of testosterone to dihydrotestosterone due to mutations in the steroid 5alpha-reductase type 2 gene (SRD5A2).
5alpha-Reductase inhibitor treatment of prostatic diseases: background and practical implications.
Altwein et al., Nürnberg, Germany. In Prostate Cancer Prostatic Dis, 2008
This literature review discusses the theoretical background of 5alpha-reductase inhibitor (5ARI) treatment and the resulting clinical implications.
46,XY DSD with Female or Ambiguous External Genitalia at Birth due to Androgen Insensitivity Syndrome, 5alpha-Reductase-2 Deficiency, or 17beta-Hydroxysteroid Dehydrogenase Deficiency: A Review of Quality of Life Outcomes.
Mazur et al., Oklahoma City, United States. In Int J Pediatr Endocrinol, 2008
The current review focuses on information published since 1955 pertaining to psychological well-being, cognition, general health, fertility, and sexual function in people affected by androgen insensitivity syndromes, 5-alpha reductase-2 deficiency, or 17beta-hydroxysteroid dehydrogenase-3 deficiency-reared male or female.
Lower urinary tract symptoms and erectile dysfunction; links for diagnosis, management and treatment.
Madersbacher et al., Vienna, Austria. In Int J Impot Res, 2007
5alpha-Reductase inhibitors are associated with ED, loss of libido and reduction of ejaculate volume in up to 10%.
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