gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation initiation factor 4E family member 2

4EHP, EIF4E2, IF-4E, tif452, 4E-LP
Top mentioned proteins: eIF4E, CAN, V1a, ACID, eIF4E3
Papers on 4EHP
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.
New
Lykke-Andersen et al., San Diego, United States. In Rna, Feb 2016
Here we identify the cap-binding translation repression 4EHP-GYF2 complex as a cofactor of TTP.
Drosophila 4EHP is essential for the larval-pupal transition and required in the prothoracic gland for ecdysone biosynthesis.
New
Gargiulo et al., Bologna, Italy. In Dev Biol, Jan 2016
UNASSIGNED: Maternal expression of the translational regulator 4EHP (eIF4E-Homologous Protein) has an established role in generating protein gradients essential for specifying the Drosophila embryonic pattern.
Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs.
New
Gao et al., Beijing, China. In Mol Cell Biol, Nov 2015
Here, we show that TTP recruits eukaryotic initiation factor 4E2 (eIF4E2) to repress target mRNA translation.
The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
New
Danen et al., Leiden, Netherlands. In Mol Cell Biol, Apr 2015
Accumulated ARIH1 associated with 4EHP, and in turn, this competitive inhibitor of the eukaryotic translation initiation factor 4E (eIF4E) underwent increased nondegradative ubiquitination upon DNA damage.
Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding.
New
Zuberek et al., Warsaw, Poland. In Biochem Biophys Res Commun, Feb 2015
Flowering plants use two eIF4E isoforms, named eIF4E and eIF(iso)4E, as canonical translation initiation factors and possess a homolog of mammalian 4EHP (or eIF4E-2) termed nCBP.
Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression.
Lee et al., Ottawa, Canada. In Cancer Res, 2014
Hypoxic cells switch from eukaryotic initiation factor 4E (eIF4E) to eIF4E2 cap-dependent translation to synthesize a portion of their proteins.
Hypoxia-inducible factor-1α (HIF-1α) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions.
Wagner et al., Boston, United States. In J Biol Chem, 2013
The eIF4E translation initiation factors, eIF4E1, eIF4E2, and eIF4E3, are essential for translation initiation.
Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.
Standart et al., Cambridge, United Kingdom. In Plos One, 2012
We investigate here the interaction of human eIF4E2 (4EHP), a class II eIF4E protein, which binds the cap weakly, with eIF4E-transporter protein, 4E-T.
Quantitative evaluation of viability- and apoptosis-related genes in Ascaris suum eggs under different culture-temperature conditions.
Lee et al., Taejŏn, South Korea. In Korean J Parasitol, 2012
Here, unembryonated A. suum eggs were incubated at 20°C, 50°C, and 70°C in vitro, and the gene expression levels related to viability, such as eukaryotic translation initiation factor 4E (IF4E), phosphofructokinase 1 (PFK1), and thioredoxin 1 (TRX1), and to apoptosis, such as apoptosis-inducing factor 1 (AIF1) and cell death protein 6 (CDP6), were evaluated by real-time quantitative RT-PCR.
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
GeneRIF
Sonenberg et al., Montréal, Canada. In Mol Cell Biol, 2012
GIGYF2 and the zinc finger protein 598 (ZNF598) are identified as components of the 4EHP complex.
An oxygen-regulated switch in the protein synthesis machinery.
Impact
Lee et al., Ottawa, Canada. In Nature, 2012
We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2α (HIF-2α), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue.
Posttranscriptional regulation in Drosophila oocytes and early embryos.
Review
Lasko, Montréal, Canada. In Wiley Interdiscip Rev Rna, 2011
Work on Vasa, a translational activator of some germ line mRNAs and on 4EHP, a negative regulator that unproductively binds the 5' cap structure of target mRNAs, is also briefly reviewed.
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
Tamura et al., Tokyo, Japan. In J Thorac Oncol, 2011
In the genome-wide association study, three SNPs were associated significantly with shortened OS after multiple comparison adjustment: rs1656402 in the EIF4E2 gene (MST was 18.0 and 7.7 months for AG [n = 50] + AA [n = 40] and GG [n = 15], respectively; p = 8.4 × 10), rs1209950 in the ETS2 gene (MST = 17.7 and 7.4 months for CC [n = 94] and CT [n = 11] + TT [n = 0]; p = 2.8 × 10), and rs9981861 in the DSCAM gene (MST = 17.1 and 3.8 months for AA [n = 75] + AG [n = 26] and GG [n = 4]; p = 3.5 × 10).
Knock-down of both eIF4E1 and eIF4E2 genes confers broad-spectrum resistance against potyviruses in tomato.
Caranta et al., Avignon, France. In Plos One, 2010
eIF4E belongs to a small multigenic family and three genes, eIF4E1, eIF4E2 and eIF(iso)4E, have been identified in tomato.
Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
GeneRIF
Cameron et al., Milano, Italy. In J Mol Biol, 2007
4EHP plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from eIF4E.
Weak binding affinity of human 4EHP for mRNA cap analogs.
GeneRIF
Darzynkiewicz et al., Warsaw, Poland. In Rna, 2007
4EHP binds cap analogs m(7)GpppG and m(7)GTP with low affinity
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.
GeneRIF
Zhang et al., Los Angeles, United States. In Genes Dev, 2007
ISGylation of 4EHP may play an important role in cap structure-dependent translation control in immune responses.
A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP.
Impact
Sonenberg et al., Montréal, Canada. In Cell, 2005
Translational control is a key genetic regulatory mechanism implicated in regulation of cell and organismal growth and early embryonic development.
Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.
GeneRIF
Blenis et al., Boston, United States. In Febs Lett, 2004
4EHP over-expression instigates a negative feedback loop that inhibits upstream signaling to 4E-BP1 and ribosomal protein S6 kinase 1 (S6K1) whereas the 4E-BP1-binding-deficient mutant of 4EHP(W95A) was unable to trigger this feedback loop
share on facebooktweetadd +1mail to friends